| Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron NK Singh, NN Singh, EJ Androphy, RN Singh Molecular and cellular biology 26 (4), 1333-1346, 2006 | 551 | 2006 |
| Diverse role of Survival Motor Neuron Protein RN Singh, MD Howell, EW Ottesen, NN Singh Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1860 (3), 299-315, 2017 | 314 | 2017 |
| Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes NN Singh, RN Singh, EJ Androphy Nucleic acids research 35 (2), 371-389, 2007 | 258 | 2007 |
| How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophy NN Singh, MD Howell, EJ Androphy, RN Singh Gene therapy 24 (9), 520-526, 2017 | 199 | 2017 |
| In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes NN Singh, EJ Androphy, RN Singh Rna 10 (8), 1291-1305, 2004 | 184 | 2004 |
| A reverse transcriptase/maturase promotes splicing by binding at its own coding segment in a group II intron RNA H Wank, J SanFilippo, RN Singh, M Matsuura, AM Lambowitz Molecular cell 4 (2), 239-250, 1999 | 183 | 1999 |
| A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy NN Singh, M Shishimorova, LC Cao, L Gangwani, RN Singh RNA biology 6 (3), 341-350, 2009 | 158 | 2009 |
| An extended inhibitory context causes skipping of exon 7 of SMN2 in spinal muscular atrophy NN Singh, EJ Androphy, RN Singh Biochemical and biophysical research communications 315 (2), 381-388, 2004 | 157 | 2004 |
| Mechanism of splicing regulation of spinal muscular atrophy genes RN Singh, NN Singh RNA Metabolism in Neurodegenerative Diseases, 31-61, 2018 | 151 | 2018 |
| Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences RN Singh, NN Singh, NK Singh, EJ Androphy US Patent 7,838,657, 2010 | 116 | 2010 |
| TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy NN Singh, J Seo, EW Ottesen, M Shishimorova, D Bhattacharya, ... Molecular and cellular biology 31 (5), 935-954, 2011 | 105 | 2011 |
| Binding of a group II intron-encoded reverse transcriptase/maturase to its high affinity intron RNA binding site involves sequence-specific recognition and autoregulates … RN Singh, RJ Saldanha, LM D'Souza, AM Lambowitz Journal of molecular biology 318 (2), 287-303, 2002 | 104 | 2002 |
| An intronic structure enabled by a long-distance interaction serves as a novel target for splicing correction in spinal muscular atrophy NN Singh, MN Lawler, EW Ottesen, D Upreti, JR Kaczynski, RN Singh Nucleic acids research 41 (17), 8144-8165, 2013 | 96 | 2013 |
| The first orally deliverable small molecule for the treatment of spinal muscular atrophy RN Singh, EW Ottesen, NN Singh Neuroscience Insights 15, 2633105520973985, 2020 | 91 | 2020 |
| Spinal muscular atrophy: an update on therapeutic progress J Seo, MD Howell, NN Singh, RN Singh Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013 | 81 | 2013 |
| Turnip Yellow Mosaic Virus RNA-Dependent RNA Polymerase: Initiation of Minus Strand Synthesisin Vitro RN Singh, TW Dreher Virology 233 (2), 430-439, 1997 | 81 | 1997 |
| Severe impairment of male reproductive organ development in a low SMN expressing mouse model of spinal muscular atrophy EW Ottesen, MD Howell, NN Singh, J Seo, EM Whitley, RN Singh Scientific reports 6 (1), 20193, 2016 | 77 | 2016 |
| Evolving concepts on human SMN pre-mRNA splicing RN Singh RNA biology 4 (1), 7-10, 2007 | 75 | 2007 |
| A multi-exon-skipping detection assay reveals surprising diversity of splice isoforms of spinal muscular atrophy genes NN Singh, J Seo, SJ Rahn, RN Singh PLoS One 7 (11), e49595, 2012 | 74 | 2012 |
| Human Survival Motor Neuron genes generate a vast repertoire of circular RNAs EW Ottesen, D Luo, J Seo, NN Singh, RN Singh Nucleic acids research 47 (6), 2884-2905, 2019 | 73 | 2019 |
Natalia SinghIowa State UniversityVerified email at iastate.edu