Cryo-EM of ribosomal 80S complexes with termination factors reveals the translocated cricket paralysis virus IRES M Muhs, T Hilal, T Mielke, MA Skabkin, KY Sanbonmatsu, TV Pestova, ... Molecular cell 57 (3), 422-432, 2015 | 109 | 2015 |
Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ N Said, T Hilal, ND Sunday, A Khatri, J Bürger, T Mielke, GA Belogurov, ... Science 371 (6524), eabd1673, 2021 | 108 | 2021 |
Molecular architecture of the ribosome‐bound Hepatitis C Virus internal ribosomal entry site RNA H Yamamoto, M Collier, J Loerke, J Ismer, A Schmidt, T Hilal, T Sprink, ... The EMBO journal 34 (24), 3042-3058, 2015 | 94 | 2015 |
tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis J Flis, M Holm, EJ Rundlet, J Loerke, T Hilal, M Dabrowski, J Bürger, ... Cell reports 25 (10), 2676-2688. e7, 2018 | 86 | 2018 |
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide NA Heyder, G Kleinau, D Speck, A Schmidt, S Paisdzior, M Szczepek, ... Cell Research 31 (11), 1176-1189, 2021 | 81 | 2021 |
Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization R Nikolay, T Hilal, S Schmidt, B Qin, D Schwefel, CH Vieira-Vieira, ... Molecular Cell 81 (6), 1200-1215. e9, 2021 | 58 | 2021 |
Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution T Hilal, H Yamamoto, J Loerke, J Bürger, T Mielke, CMT Spahn Nature communications 7 (1), 13521, 2016 | 58 | 2016 |
Structural visualization of the formation and activation of the 50S ribosomal subunit during in vitro reconstitution R Nikolay, T Hilal, B Qin, T Mielke, J Bürger, J Loerke, K Textoris-Taube, ... Molecular cell 70 (5), 881-893. e3, 2018 | 57 | 2018 |
Structure-based mechanisms of a molecular RNA polymerase/chaperone machine required for ribosome biosynthesis YH Huang, T Hilal, B Loll, J Bürger, T Mielke, C Böttcher, N Said, ... Molecular cell 79 (6), 1024-1036. e5, 2020 | 49 | 2020 |
Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon T Hilal, BY Killam, M Grozdanović, M Dobosz-Bartoszek, J Loerke, ... Science 376 (6599), 1338-1343, 2022 | 44 | 2022 |
The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling HH Pei, T Hilal, ZA Chen, YH Huang, Y Gao, N Said, B Loll, J Rappsilber, ... Nature Communications 11 (1), 6418, 2020 | 40 | 2020 |
A dual estrogen receptor TR-FRET assay for simultaneous measurement of steroid site binding and coactivator recruitment T Hilal, V Puetter, C Otto, K Parczyk, B Bader Journal of Biomolecular screening 15 (3), 268-278, 2010 | 23 | 2010 |
The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling A Bergfort, T Hilal, B Kuropka, İA Ilik, G Weber, T Aktaş, C Freund, ... Nucleic Acids Research 50 (5), 2938-2958, 2022 | 15 | 2022 |
Ribosome rescue and protein quality control in concert T Hilal, CMT Spahn Molecular cell 57 (3), 389-390, 2015 | 15 | 2015 |
A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing A Bergfort, M Preußner, B Kuropka, İA Ilik, T Hilal, G Weber, C Freund, ... Nature Communications 13 (1), 1132, 2022 | 11 | 2022 |
Concerted transformation of a hyper-paused transcription complex and its reinforcing protein PK Zuber, N Said, T Hilal, B Wang, B Loll, J González-Higueras, ... Nature Communications 15 (1), 3040, 2024 | 10 | 2024 |
Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex J Jia, T Hilal, KE Bohnsack, A Chernev, N Tsao, J Bethmann, ... Nature communications 14 (1), 1886, 2023 | 7 | 2023 |
Sm-like protein Rof inhibits transcription termination factor ρ by binding site obstruction and conformational insulation N Said, M Finazzo, T Hilal, B Wang, TL Selinger, D Gjorgjevikj, ... Nature Communications 15 (1), 3186, 2024 | 6 | 2024 |
Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science 371: eabd1673 N Said, T Hilal, ND Sunday, A Khatri, J Burger, T Mielke, GA Belogurov, ... | 6 | 2021 |
Widespread gene regulator Psu inhibits transcription termination factor ρ by forced hyper-oligomerization D Gjorgjevikj, N Kumar, B Wang, T Hilal, N Said, B Loll, I Artsimovitch, ... bioRxiv, 2023.06. 22.546067, 2023 | 5 | 2023 |