| Synthetic molecules that fold into a pleated secondary structure in solution R Scott Lokey, BL Iverson Nature 375 (6529), 303-305, 1995 | 659 | 1995 |
| Retrospective analysis of natural products provides insights for future discovery trends CR Pye, MJ Bertin, RS Lokey, WH Gerwick, RG Linington Proceedings of the National Academy of Sciences 114 (22), 5601-5606, 2017 | 597 | 2017 |
| Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers T Rezai, B Yu, GL Millhauser, MP Jacobson, RS Lokey Journal of the American Chemical Society 128 (8), 2510-2511, 2006 | 583 | 2006 |
| Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides T Rezai, JE Bock, MV Zhou, C Kalyanaraman, RS Lokey, MP Jacobson Journal of the American Chemical Society 128 (43), 14073-14080, 2006 | 474 | 2006 |
| On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds TR White, CM Renzelman, AC Rand, T Rezai, CM McEwen, VM Gelev, ... Nature chemical biology 7 (11), 810-817, 2011 | 418 | 2011 |
| Cell-permeable cyclic peptides from synthetic libraries inspired by natural products WM Hewitt, SSF Leung, CR Pye, AR Ponkey, M Bednarek, MP Jacobson, ... Journal of the American Chemical Society 137 (2), 715-721, 2015 | 250 | 2015 |
| Form and function in cyclic peptide natural products: a pharmacokinetic perspective AT Bockus, CM McEwen, RS Lokey Current topics in medicinal chemistry 13 (7), 821-836, 2013 | 233 | 2013 |
| Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides RA Turner, AG Oliver, RS Lokey Organic letters 9 (24), 5011-5014, 2007 | 231 | 2007 |
| Cross‐species chemogenomic profiling reveals evolutionarily conserved drug mode of action L Kapitzky, P Beltrao, TJ Berens, N Gassner, C Zhou, A Wüster, J Wu, ... Molecular systems biology 6 (1), 451, 2010 | 192 | 2010 |
| Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products CL Ahlbach, KW Lexa, AT Bockus, V Chen, P Crews, MP Jacobson, ... Future medicinal chemistry 7 (16), 2121-2130, 2015 | 180 | 2015 |
| Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets MR Naylor, AT Bockus, MJ Blanco, RS Lokey Current opinion in chemical biology 38, 141-147, 2017 | 168 | 2017 |
| Lipophilic permeability efficiency reconciles the opposing roles of lipophilicity in membrane permeability and aqueous solubility MR Naylor, AM Ly, MJ Handford, DP Ramos, CR Pye, A Furukawa, ... Journal of medicinal chemistry 61 (24), 11169-11182, 2018 | 161 | 2018 |
| Probing the physicochemical boundaries of cell permeability and oral bioavailability in lipophilic macrocycles inspired by natural products AT Bockus, KW Lexa, CR Pye, AS Kalgutkar, JW Gardner, KCR Hund, ... Journal of Medicinal Chemistry 58 (11), 4581-4589, 2015 | 158 | 2015 |
| Nonclassical size dependence of permeation defines bounds for passive adsorption of large drug molecules CR Pye, WM Hewitt, J Schwochert, TD Haddad, CE Townsend, L Etienne, ... Journal of medicinal chemistry 60 (5), 1665-1672, 2017 | 148 | 2017 |
| A new class of polyintercalating molecules RS Lokey, Y Kwok, V Guelev, CJ Pursell, LH Hurley, BL Iverson Journal of the American Chemical Society 119 (31), 7202-7210, 1997 | 147 | 1997 |
| Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance AC Rand, SSF Leung, H Eng, CJ Rotter, R Sharma, AS Kalgutkar, ... MedChemComm 3 (10), 1282-1289, 2012 | 143 | 2012 |
| Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia RS Lokey Current Opinion in Chemical Biology 7 (1), 91-96, 2003 | 140 | 2003 |
| Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of … AT Bockus, JA Schwochert, CR Pye, CE Townsend, V Sok, MA Bednarek, ... Journal of Medicinal Chemistry 58 (18), 7409-7418, 2015 | 130 | 2015 |
| Understanding and improving the membrane permeability of VH032-based PROTACs VG Klein, CE Townsend, A Testa, M Zengerle, C Maniaci, SJ Hughes, ... ACS medicinal chemistry letters 11 (9), 1732-1738, 2020 | 116 | 2020 |
| “Function-first” lead discovery: mode of action profiling of natural product libraries using image-based screening CJ Schulze, WM Bray, MH Woerhmann, J Stuart, RS Lokey, RG Linington Chemistry & biology 20 (2), 285-295, 2013 | 110 | 2013 |