Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders L M Valor, J Viosca, J P Lopez-Atalaya, A Barco Current pharmaceutical design 19 (28), 5051-5064, 2013 | 182 | 2013 |
Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability LM Valor, MM Pulopulos, M Jimenez-Minchan, R Olivares, B Lutz, ... Journal of Neuroscience 31 (5), 1652-1663, 2011 | 152 | 2011 |
cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression E Benito, LM Valor, M Jimenez-Minchan, W Huber, A Barco Journal of neuroscience 31 (50), 18237-18250, 2011 | 134 | 2011 |
CBP is required for environmental enrichment‐induced neurogenesis and cognitive enhancement JP Lopez‐Atalaya, A Ciccarelli, J Viosca, LM Valor, M Jimenez‐Minchan, ... The EMBO journal 30 (20), 4287-4298, 2011 | 129 | 2011 |
Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration D Jancic, M Lopez de Armentia, LM Valor, R Olivares, A Barco Cerebral cortex 19 (11), 2535-2547, 2009 | 120 | 2009 |
Transcription, epigenetics and ameliorative strategies in Huntington’s Disease: a genome-wide perspective LM Valor Molecular neurobiology 51, 406-423, 2015 | 118 | 2015 |
Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition JP Lopez-Atalaya, S Ito, LM Valor, E Benito, A Barco Nucleic acids research 41 (17), 8072-8084, 2013 | 118 | 2013 |
International consensus recommendations on the diagnostic work-up for malformations of cortical development R Oegema, TS Barakat, M Wilke, K Stouffs, D Amrom, E Aronica, ... Nature Reviews Neurology 16 (11), 618-635, 2020 | 112 | 2020 |
Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors F Sala, J Mulet, S Choi, SY Jung, SY Nah, H Rhim, LM Valor, M Criado, ... Journal of Pharmacology and Experimental Therapeutics 301 (3), 1052-1059, 2002 | 98 | 2002 |
Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease LM Valor, D Guiretti, JP Lopez-Atalaya, A Barco Journal of Neuroscience 33 (25), 10471-10482, 2013 | 85 | 2013 |
Potentiation of human α4β2 neuronal nicotinic receptors by a Flustra foliacea metabolite F Sala, J Mulet, KP Reddy, JA Bernal, P Wikman, LM Valor, L Peters, ... Neuroscience letters 373 (2), 144-149, 2005 | 79 | 2005 |
Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes S Choi, SY Jung, JH Lee, F Sala, M Criado, J Mulet, LM Valor, S Sala, ... European journal of pharmacology 442 (1-2), 37-45, 2002 | 72 | 2002 |
Binge-like consumption of caloric and non-caloric palatable substances in ad libitum-fed C57BL/6J mice: pharmacological and molecular evidence of orexin involvement M Alcaraz-Iborra, F Carvajal, JM Lerma-Cabrera, LM Valor, I Cubero Behavioural brain research 272, 93-99, 2014 | 68 | 2014 |
What's wrong with epigenetics in Huntington's disease? LM Valor, D Guiretti Neuropharmacology 80, 103-114, 2014 | 63 | 2014 |
Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus MP Coba, LM Valor, MV Kopanitsa, NO Afinowi, SGN Grant Journal of Biological Chemistry 283 (49), 34101-34107, 2008 | 62 | 2008 |
CREB regulates distinct adaptive transcriptional programs in astrocytes and neurons L Pardo, LM Valor, A Eraso-Pichot, A Barco, A Golbano, GE Hardingham, ... Scientific reports 7 (1), 6390, 2017 | 55 | 2017 |
Early alteration of epigenetic-related transcription in Huntington’s disease mouse models I Hervás-Corpión, D Guiretti, M Alcaraz-Iborra, R Olivares, ... Scientific reports 8 (1), 9925, 2018 | 51 | 2018 |
Role of the large cytoplasmic loop of the α7 neuronal nicotinic acetylcholine receptor subunit in receptor expression and function LM Valor, J Mulet, F Sala, S Sala, JJ Ballesta, M Criado Biochemistry 41 (25), 7931-7938, 2002 | 47 | 2002 |
Network activity-independent coordinated gene expression program for synapse assembly LM Valor, P Charlesworth, L Humphreys, CNG Anderson, SGN Grant Proceedings of the National Academy of Sciences 104 (11), 4658-4663, 2007 | 45 | 2007 |
Epigenetic factors in intellectual disability: the Rubinstein–Taybi syndrome as a paradigm of neurodevelopmental disorder with epigenetic origin JP Lopez-Atalaya, LM Valor, A Barco Progress in molecular biology and translational science 128, 139-176, 2014 | 44 | 2014 |