| Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice RA Miller, DE Harrison, CM Astle, JA Baur, AR Boyd, R De Cabo, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2011 | 1009 | 2011 |
| Tissue-specific contributions of pneumococcal virulence factors to pathogenesis CJ Orihuela, G Gao, KP Francis, J Yu, EI Tuomanen Journal of Infectious Diseases 190 (9), 1661-1669, 2004 | 411 | 2004 |
| Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models CJ Orihuela, J Mahdavi, J Thornton, B Mann, KG Wooldridge, ... The Journal of clinical investigation 119 (6), 1638-1646, 2009 | 353 | 2009 |
| Microarray analysis of pneumococcal gene expression during invasive disease CJ Orihuela, JN Radin, JE Sublett, G Gao, D Kaushal, EI Tuomanen Infection and immunity 72 (10), 5582-5596, 2004 | 303 | 2004 |
| Pore-forming toxins induce macrophage necroptosis during acute bacterial pneumonia N González-Juarbe, RP Gilley, CA Hinojosa, KM Bradley, A Kamei, G Gao, ... PLoS pathogens 11 (12), e1005337, 2015 | 242 | 2015 |
| The Pneumococcal Serine-Rich Repeat Protein Is an Intra-Species Bacterial Adhesin That Promotes Bacterial Aggregation In Vivo and in Biofilms CJ Sanchez, P Shivshankar, K Stol, S Trakhtenbroit, PM Sullam, K Sauer, ... PLoS pathogens 6 (8), e1001044, 2010 | 234 | 2010 |
| Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells L Xue, SW Morris, C Orihuela, E Tuomanen, X Cui, R Wen, D Wang Nature immunology 4 (9), 857-865, 2003 | 227 | 2003 |
| Identification of a Candidate Streptococcus pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease C Obert, J Sublett, D Kaushal, E Hinojosa, T Barton, EI Tuomanen, ... Infection and immunity 74 (8), 4766-4777, 2006 | 222 | 2006 |
| Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function AO Brown, B Mann, G Gao, JS Hankins, J Humann, J Giardina, P Faverio, ... PLoS pathogens 10 (9), e1004383, 2014 | 216 | 2014 |
| β-Arrestin 1 Participates in Platelet-Activating Factor Receptor-Mediated Endocytosis of Streptococcus pneumoniae JN Radin, CJ Orihuela, G Murti, C Guglielmo, PJ Murray, EI Tuomanen Infection and immunity 73 (12), 7827-7835, 2005 | 189 | 2005 |
| NAD+ depletion triggers macrophage necroptosis, a cell death pathway exploited by Mycobacterium tuberculosis D Pajuelo, N Gonzalez-Juarbe, U Tak, J Sun, CJ Orihuela, M Niederweis Cell reports 24 (2), 429-440, 2018 | 176 | 2018 |
| The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells P Shivshankar, C Sanchez, LF Rose, CJ Orihuela Molecular microbiology 73 (4), 663-679, 2009 | 170 | 2009 |
| Induction of pro-and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza MW Smith, JE Schmidt, JE Rehg, CJ Orihuela, JA McCullers Comparative medicine 57 (1), 82-89, 2007 | 170 | 2007 |
| Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia E Hinojosa, AR Boyd, CJ Orihuela The Journal of infectious diseases 200 (4), 546-554, 2009 | 165 | 2009 |
| Streptococcus pneumoniae: Invasion and Inflammation AJ Loughran, CJ Orihuela, EI Tuomanen Microbiology spectrum 7 (2), 10.1128/microbiolspec. gpp3-0004-2018, 2019 | 155 | 2019 |
| Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production CJ Sanchez, N Kumar, A Lizcano, P Shivshankar, JC Dunning Hotopp, ... PloS one 6 (12), e28738, 2011 | 153 | 2011 |
| Incidence of cardiovascular events after hospital admission for pneumonia TW Perry, MJV Pugh, GW Waterer, B Nakashima, CJ Orihuela, ... The American journal of medicine 124 (3), 244-251, 2011 | 137 | 2011 |
| Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans A Sandgren, B Albiger, CJ Orihuela, E Tuomanen, S Normark, ... The Journal of infectious diseases 192 (5), 791-800, 2005 | 135 | 2005 |
| Severe pneumococcal pneumonia causes acute cardiac toxicity and subsequent cardiac remodeling LF Reyes, MI Restrepo, CA Hinojosa, NJ Soni, A Anzueto, BL Babu, ... American Journal of Respiratory and Critical Care Medicine 196 (5), 609-620, 2017 | 133 | 2017 |
| Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia AR Boyd, P Shivshankar, S Jiang, MT Berton, CJ Orihuela Experimental gerontology 47 (7), 507-518, 2012 | 133 | 2012 |
Norberto Gonzalez-JuarbeJ. Craig Venter InstituteVerified email at jcvi.org
