| cGAS surveillance of micronuclei links genome instability to innate immunity KJ Mackenzie, P Carroll, CA Martin, O Murina, A Fluteau, DJ Simpson, ... Nature 548 (7668), 461-465, 2017 | 1572 | 2017 |
| SC3: consensus clustering of single-cell RNA-seq data VY Kiselev, K Kirschner, MT Schaub, T Andrews, A Yiu, T Chandra, ... Nature methods 14 (5), 483-486, 2017 | 1439 | 2017 |
| Global reorganization of the nuclear landscape in senescent cells T Chandra, PA Ewels, S Schoenfelder, M Furlan-Magaril, SW Wingett, ... Cell reports 10 (4), 471-483, 2015 | 352 | 2015 |
| Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence M Sadaie, R Salama, T Carroll, K Tomimatsu, T Chandra, ARJ Young, ... Genes & development 27 (16), 1800-1808, 2013 | 351 | 2013 |
| Single-cell landscape of transcriptional heterogeneity and cell fate decisions during mouse early gastrulation H Mohammed, I Hernando-Herraez, A Savino, A Scialdone, I Macaulay, ... Cell reports 20 (5), 1215-1228, 2017 | 338 | 2017 |
| Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase P Stepper, G Kungulovski, RZ Jurkowska, T Chandra, F Krueger, ... Nucleic acids research 45 (4), 1703-1713, 2017 | 331 | 2017 |
| Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation T Chandra, K Kirschner, JY Thuret, BD Pope, T Ryba, S Newman, ... Molecular cell 47 (2), 203-214, 2012 | 317 | 2012 |
| Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity N Olova, DJ Simpson, RE Marioni, T Chandra Aging cell 18 (1), e12877, 2019 | 167 | 2019 |
| Experimental design for single-cell RNA sequencing J Baran-Gale, T Chandra, K Kirschner Briefings in functional genomics 17 (4), 233-239, 2018 | 159 | 2018 |
| Epigenetic age prediction DJ Simpson, T Chandra Aging cell 20 (9), e13452, 2021 | 149 | 2021 |
| Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease BR Conway, ED O’Sullivan, C Cairns, J O’Sullivan, DJ Simpson, ... Journal of the American Society of Nephrology 31 (12), 2833-2854, 2020 | 149 | 2020 |
| Deletion of the polycomb-group protein EZH2 leads to compromised self-renewal and differentiation defects in human embryonic stem cells A Collinson, AJ Collier, NP Morgan, AR Sienerth, T Chandra, S Andrews, ... Cell reports 17 (10), 2700-2714, 2016 | 141 | 2016 |
| Notch signaling mediates secondary senescence YV Teo, N Rattanavirotkul, N Olova, A Salzano, A Quintanilla, N Tarrats, ... Cell reports 27 (4), 997-1007. e5, 2019 | 119 | 2019 |
| Cellular reprogramming and epigenetic rejuvenation DJ Simpson, NN Olova, T Chandra Clinical epigenetics 13, 1-10, 2021 | 104 | 2021 |
| Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment K Kirschner, T Chandra, V Kiselev, D Flores-Santa Cruz, IC Macaulay, ... Cell reports 19 (8), 1503-1511, 2017 | 100 | 2017 |
| Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer S Haston, E Gonzalez-Gualda, S Morsli, J Ge, V Reen, A Calderwood, ... Cancer Cell 41 (7), 1242-1260. e6, 2023 | 94 | 2023 |
| An endosiRNA-based repression mechanism counteracts transposon activation during global DNA demethylation in embryonic stem cells RV Berrens, S Andrews, D Spensberger, F Santos, W Dean, P Gould, ... Cell stem cell 21 (5), 694-703. e7, 2017 | 88 | 2017 |
| Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects NA Robertson, E Latorre-Crespo, M Terradas-Terradas, J Lemos-Portela, ... Nature medicine 28 (7), 1439-1446, 2022 | 87 | 2022 |
| An epigenome-wide association study of sex-specific chronological ageing DL McCartney, F Zhang, RF Hillary, Q Zhang, AJ Stevenson, RM Walker, ... Genome medicine 12, 1-11, 2020 | 73 | 2020 |
| Functional heterogeneity in senescence K Kirschner, N Rattanavirotkul, MF Quince, T Chandra Biochemical Society Transactions 48 (3), 765-773, 2020 | 72 | 2020 |
Wolf ReikHead, Epigenetics Programme, Babraham Institute Cambridge, UKVerified email at babraham.ac.uk