| Exosomes as mediators of intercellular crosstalk in metabolism R Isaac, FCG Reis, W Ying, JM Olefsky Cell metabolism 33 (9), 1744-1762, 2021 | 450 | 2021 |
| Expansion of islet-resident macrophages leads to inflammation affecting β cell proliferation and function in obesity W Ying, YS Lee, Y Dong, JS Seidman, M Yang, R Isaac, JB Seo, BH Yang, ... Cell metabolism 29 (2), 457-474. e5, 2019 | 254 | 2019 |
| Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells R Isaac, S Boura-Halfon, D Gurevitch, A Shainskaya, Y Levkovitz, Y Zick Journal of biological chemistry 288 (8), 5682-5693, 2013 | 97 | 2013 |
| TAZ is a negative regulator of PPARγ activity in adipocytes and TAZ deletion improves insulin sensitivity and glucose tolerance D El Ouarrat, R Isaac, YS Lee, J Wollam, D Lackey, M Riopel, ... Cell metabolism 31 (1), 162-173. e5, 2020 | 93 | 2020 |
| Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases Y Levkovitz, G Ben-Shushan, A Hershkovitz, R Isaac, I Gil-Ad, ... Molecular and Cellular Neuroscience 36 (3), 305-312, 2007 | 71 | 2007 |
| Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth M Cao, R Isaac, W Yan, X Ruan, L Jiang, Y Wan, J Wang, E Wang, ... Nature cell biology 24 (6), 954-967, 2022 | 70 | 2022 |
| Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 Y Ji, Z Luo, H Gao, FCG Dos Reis, G Bandyopadhyay, Z Jin, KA Manda, ... Nature metabolism 3 (9), 1163-1174, 2021 | 59 | 2021 |
| Prolonged insulin treatment sensitizes apoptosis pathways in pancreatic β cells E Bucris, A Beck, S Boura-Halfon, R Isaac, Y Vinik, T Rosenzweig, ... J Endocrinol 230 (3), 291-307, 2016 | 32 | 2016 |
| The animal lectin galectin-8 promotes cytokine expression and metastatic tumor growth in mice H Shatz-Azoulay, Y Vinik, R Isaac, U Kohler, S Lev, Y Zick Scientific reports 10 (1), 7375, 2020 | 30 | 2020 |
| Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets A Beck, Y Vinik, H Shatz-Azoulay, R Isaac, S Streim, G Jona, ... Diabetologia 56 (6), 1317-1326, 2013 | 27 | 2013 |
| Elimination of negative feedback control mechanisms along the insulin signaling pathway improves β-cell function under stress D Gurevitch, S Boura-Halfon, R Isaac, G Shahaf, M Alberstein, D Ronen, ... Diabetes 59 (9), 2188-2197, 2010 | 24 | 2010 |
| TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response R Isaac, I Goldstein, N Furth, N Zilber, S Streim, S Boura-Halfon, ... Cell Death & Differentiation 24 (1), 132-143, 2017 | 21 | 2017 |
| An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells A Beck, R Isaac, I Lavelin, Y Hart, T Volberg, H Shatz-Azoulay, B Geiger, ... Diabetologia 54, 2845-2855, 2011 | 20 | 2011 |
| Adipocyte PU. 1 knockout promotes insulin sensitivity in HFD-fed obese mice DE Lackey, FCG Reis, R Isaac, RC Zapata, D El Ouarrat, YS Lee, ... Scientific reports 9 (1), 14779, 2019 | 16 | 2019 |
| Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins N DeForest, B Kavitha, S Hu, R Isaac, L Krohn, M Wang, X Du, ... Cell Genomics 3 (7), 2023 | 8 | 2023 |
| HIF-2α preserves mitochondrial activity and glucose sensing in compensating β-cells in obesity JS Moon, M Riopel, JB Seo, V Herrero-Aguayo, R Isaac, YS Lee Diabetes 71 (7), 1508-1524, 2022 | 7 | 2022 |
| Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells. R Isaac, S Boura-Halfon, D Gurevitch, A Shainskaya, Y Levkovitz, Y Zick The Journal of biological chemistry 293 (12), 4577, 2018 | 6 | 2018 |
| Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells A Beck, H Shatz-Azoulay, Y Vinik, R Isaac, S Boura-Halfon, Y Zick Biochemical and Biophysical Research Communications 465 (4), 851-856, 2015 | 6 | 2015 |
| Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization TV Rohm, F Castellani Gomes Dos Reis, R Isaac, C Murphy, ... Nature Metabolism, 1-19, 2024 | 5 | 2024 |
| Prolonged elimination of negative feedback control mechanisms along the insulin signaling pathway impairs β-cell function in vivo R Isaac, Y Vinik, S Boura-Halfon, L Farack, S Streim, E Elhanany, Z Kam, ... Diabetes 66 (7), 1879-1889, 2017 | 5 | 2017 |
Sigalit Boura-HalfonStaff Scientist Weizmann Institute of ScienceVerified email at weizmann.ac.il
