| Vaborbactam: spectrum of beta-lactamase inhibition and impact of resistance mechanisms on activity in Enterobacteriaceae O Lomovskaya, D Sun, D Rubio-Aparicio, K Nelson, R Tsivkovski, ... Antimicrobial agents and chemotherapy 61 (11), 10.1128/aac. 01443-17, 2017 | 361 | 2017 |
| Discovery of cyclic boronic acid QPX7728, an ultrabroad-spectrum inhibitor of serine and metallo-β-lactamases SJ Hecker, KR Reddy, O Lomovskaya, DC Griffith, D Rubio-Aparicio, ... Journal of medicinal chemistry 63 (14), 7491-7507, 2020 | 188 | 2020 |
| Resistance to ceftazidime-avibactam is due to transposition of KPC in a porin-deficient strain of Klebsiella pneumoniae with increased efflux activity K Nelson, P Hemarajata, D Sun, D Rubio-Aparicio, R Tsivkovski, S Yang, ... Antimicrobial agents and chemotherapy 61 (10), 10.1128/aac. 00989-17, 2017 | 167 | 2017 |
| Meropenem-vaborbactam resistance selection, resistance prevention, and molecular mechanisms in mutants of KPC-producing Klebsiella pneumoniae D Sun, D Rubio-Aparicio, K Nelson, MN Dudley, O Lomovskaya Antimicrobial agents and chemotherapy 61 (12), 10.1128/aac. 01694-17, 2017 | 162 | 2017 |
| Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents LW Tari, X Li, M Trzoss, DC Bensen, Z Chen, T Lam, J Zhang, SJ Lee, ... PloS one 8 (12), e84409, 2013 | 111 | 2013 |
| Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity M Trzoss, DC Bensen, X Li, Z Chen, T Lam, J Zhang, CJ Creighton, ... Bioorganic & medicinal chemistry letters 23 (5), 1537-1543, 2013 | 91 | 2013 |
| Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2, 4-diaminoquinazolines T Lam, MT Hilgers, ML Cunningham, BP Kwan, KJ Nelson, ... Journal of medicinal chemistry 57 (3), 651-668, 2014 | 90 | 2014 |
| Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2, 4-diaminoquinazolines X Li, M Hilgers, M Cunningham, Z Chen, M Trzoss, J Zhang, L Kohnen, ... Bioorganic & medicinal chemistry letters 21 (18), 5171-5176, 2011 | 59 | 2011 |
| Spectrum of beta-lactamase inhibition by the cyclic boronate QPX7728, an ultrabroad-spectrum beta-lactamase inhibitor of serine and metallo-beta-lactamases: enhancement of … O Lomovskaya, R Tsivkovski, K Nelson, D Rubio-Aparicio, D Sun, ... Antimicrobial Agents and Chemotherapy 64 (6), 10.1128/aac. 00212-20, 2020 | 54 | 2020 |
| Impact of intrinsic resistance mechanisms on potency of QPX7728, a new ultrabroad-spectrum beta-lactamase inhibitor of serine and metallo-beta-lactamases in Enterobacteriaceae … O Lomovskaya, K Nelson, D Rubio-Aparicio, R Tsivkovski, D Sun, ... Antimicrobial agents and chemotherapy 64 (6), 10.1128/aac. 00552-20, 2020 | 50 | 2020 |
| In Vitro Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales with Varying Intrinsic and … K Nelson, D Rubio-Aparicio, D Sun, M Dudley, O Lomovskaya Antimicrobial agents and chemotherapy 64 (8), 10.1128/aac. 00757-20, 2020 | 42 | 2020 |
| Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay ML Cunningham, BP Kwan, KJ Nelson, DC Bensen, KJ Shaw Journal of biomolecular screening 18 (9), 1018-1026, 2013 | 39 | 2013 |
| Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors LW Tari, ID Hoffman, DC Bensen, MJ Hunter, J Nix, KJ Nelson, DE McRee, ... Bioorganic & medicinal chemistry letters 17 (3), 688-691, 2007 | 37 | 2007 |
| In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant … K Nelson, D Rubio-Aparicio, R Tsivkovski, D Sun, M Totrov, M Dudley, ... Antimicrobial Agents and Chemotherapy 64 (11), 10.1128/aac. 01406-20, 2020 | 25 | 2020 |
| Intrinsic Antibacterial Activity of Xeruborbactam In Vitro: Assessing Spectrum and Mode of Action D Sun, R Tsivkovski, J Pogliano, H Tsunemoto, K Nelson, ... Antimicrobial Agents and Chemotherapy 66 (10), e00879-22, 2022 | 23 | 2022 |
| In Vitro Activity of the Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas … O Lomovskaya, D Rubio-Aparicio, K Nelson, D Sun, R Tsivkovski, ... Antimicrobial agents and chemotherapy 65 (6), 10.1128/aac. 00210-21, 2021 | 22 | 2021 |
| In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against … O Lomovskaya, M Castanheira, J Lindley, D Rubio-Aparicio, K Nelson, ... Antimicrobial Agents and Chemotherapy 67 (11), e00440-23, 2023 | 18 | 2023 |
| Absence of TetB identifies minocycline-susceptible isolates of Acinetobacter baumannii O Lomovskaya, D Sun, D Rubio-Aparicio, KJ Nelson, V Thamlikitkul, ... International journal of antimicrobial agents 52 (3), 404-406, 2018 | 18 | 2018 |
| Assessment of MIC increases with meropenem-vaborbactam and ceftazidime-avibactam in TANGO II (a phase 3 study of the treatment of CRE infections) O Lomovskaya, M Castanheira, J Vazquez, KS Kaye, K Nelson, D Sun, ... Open Forum Infectious Diseases 4 (suppl_1), S540-S540, 2017 | 18 | 2017 |
| TetB Testing and Its Absence Identifies Minocycline (MINO) Susceptible Isolates of Acinetobacter baumannii (ACB) O Lomovskaya, D Sun, D Rubio-Aparicio, K Nelson, MN Dudley Open Forum Infectious Diseases 3 (suppl_1), 2043, 2016 | 7 | 2016 |