| Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques NB Mercado, R Zahn, F Wegmann, C Loos, A Chandrashekar, J Yu, J Liu, ... Nature 586 (7830), 583-588, 2020 | 1009 | 2020 |
| Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses R Bos, L Rutten, JEM van der Lubbe, MJG Bakkers, G Hardenberg, ... npj Vaccines 5 (1), 91, 2020 | 379 | 2020 |
| Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site L Vandeputte‐Rutten, RA Kramer, J Kroon, N Dekker, MR Egmond, ... The EMBO journal, 2001 | 366 | 2001 |
| Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase M Kotaka, S Gover, L Vandeputte-Rutten, SWN Au, VMS Lam, MJ Adams Biological Crystallography 61 (5), 495-504, 2005 | 215 | 2005 |
| Crystal structure of Neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential L Vandeputte-Rutten, MP Bos, J Tommassen, P Gros Journal of Biological Chemistry 278 (27), 24825-24830, 2003 | 167 | 2003 |
| Stabilizing the closed SARS-CoV-2 spike trimer J Juraszek, L Rutten, S Blokland, P Bouchier, R Voorzaat, T Ritschel, ... Nature communications 12 (1), 244, 2021 | 156 | 2021 |
| Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization LE McCoy, AF Quigley, NM Strokappe, B Bulmer-Thomas, MS Seaman, ... Journal of Experimental Medicine 209 (6), 1091-1103, 2012 | 131 | 2012 |
| Autotransporter secretion: varying on a theme J Grijpstra, J Arenas, L Rutten, J Tommassen Research in microbiology 164 (6), 562-582, 2013 | 130 | 2013 |
| Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT RA Kramer, K Brandenburg, L Vandeputte‐Rutten, M Werkhoven, P Gros, ... European journal of biochemistry 269 (6), 1746-1752, 2002 | 110 | 2002 |
| A universal approach to optimize the folding and stability of prefusion-closed HIV-1 envelope trimers L Rutten, YT Lai, S Blokland, D Truan, IJM Bisschop, NM Strokappe, ... Cell reports 23 (2), 584-595, 2018 | 100 | 2018 |
| Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa L Rutten, J Geurtsen, W Lambert, JJM Smolenaers, AM Bonvin, ... Proceedings of the National Academy of Sciences 103 (18), 7071-7076, 2006 | 96 | 2006 |
| A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition D Lutje Hulsik, Y Liu, NM Strokappe, S Battella, M El Khattabi, LE McCoy, ... PLoS pathogens 9 (3), e1003202, 2013 | 93 | 2013 |
| Identification of essential acidic residues of outer membrane protease OmpT supports a novel active site RA Kramer, L Vandeputte-Rutten, GJ de Roon, P Gros, N Dekker, ... FEBS letters 505 (3), 426-430, 2001 | 70 | 2001 |
| Structure-based design of prefusion-stabilized filovirus glycoprotein trimers L Rutten, MSA Gilman, S Blokland, J Juraszek, JS McLellan, ... Cell reports 30 (13), 4540-4550. e3, 2020 | 67 | 2020 |
| An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc mesenteroides Glucose 6-Phosphate Dehydrogenase: X-ray Structure and pH … MS Cosgrove, S Gover, CE Naylor, L Vandeputte-Rutten, MJ Adams, ... Biochemistry 39 (49), 15002-15011, 2000 | 67 | 2000 |
| Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium L Rutten, JPBA Mannie, CM Stead, CRH Raetz, CM Reynolds, ... Proceedings of the National Academy of Sciences 106 (6), 1960-1964, 2009 | 66 | 2009 |
| Ad26. COV2. S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease JEM van Der Lubbe, SK Rosendahl Huber, A Vijayan, L Dekking, ... npj Vaccines 6 (1), 39, 2021 | 62 | 2021 |
| Molecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1 LE McCoy, L Rutten, D Frampton, I Anderson, L Granger, ... PLoS pathogens 10 (12), e1004552, 2014 | 60 | 2014 |
| Neutralisation of HIV-1 cell-cell spread by human and llama antibodies LE McCoy, E Groppelli, C Blanchetot, H de Haard, T Verrips, L Rutten, ... Retrovirology 11, 1-15, 2014 | 54 | 2014 |
| Solution of the structure of tetrameric human glucose 6-phosphate dehydrogenase by molecular replacement SWN Au, CE Naylor, S Gover, L Vandeputte-Rutten, DA Scopes, ... Acta Crystallographica Section D: Biological Crystallography 55 (4), 826-834, 1999 | 53 | 1999 |