| Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262-265, 2009 | 7444 | 2009 |
| Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ... Gastroenterology 141 (5), 1762-1772, 2011 | 3909 | 2011 |
| Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415-418, 2011 | 2893 | 2011 |
| Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ... Cell 143 (1), 134-144, 2010 | 2116 | 2010 |
| Lgr5+ ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ... Cell stem cell 6 (1), 25-36, 2010 | 1818 | 2010 |
| In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ... Nature 494 (7436), 247-250, 2013 | 1714 | 2013 |
| Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications T Sato, H Clevers Science 340 (6137), 1190-1194, 2013 | 1349 | 2013 |
| Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids M Matano, S Date, M Shimokawa, A Takano, M Fujii, Y Ohta, T Watanabe, ... Nature medicine 21 (3), 256-262, 2015 | 1218 | 2015 |
| Tissue-specific mutation accumulation in human adult stem cells during life F Blokzijl, J De Ligt, M Jager, V Sasselli, S Roerink, N Sasaki, M Huch, ... Nature 538 (7624), 260-264, 2016 | 943 | 2016 |
| Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell S Yui, T Nakamura, T Sato, Y Nemoto, T Mizutani, X Zheng, S Ichinose, ... Nature medicine 18 (4), 618-623, 2012 | 928 | 2012 |
| Dll1+ secretory progenitor cells revert to stem cells upon crypt damage JH Van Es, T Sato, M Van De Wetering, A Lyubimova, AN Yee Nee, ... Nature cell biology 14 (10), 1099-1104, 2012 | 890 | 2012 |
| Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis N Kamada, T Hisamatsu, S Okamoto, H Chinen, T Kobayashi, T Sato, ... The Journal of clinical investigation 118 (6), 2269-2280, 2008 | 876 | 2008 |
| Mapping the human genetic architecture of COVID-19 Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ... Nature 600 (7889), 472-477, 2021 | 838 | 2021 |
| A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis M Fujii, M Shimokawa, S Date, A Takano, M Matano, K Nanki, Y Ohta, ... Cell stem cell 18 (6), 827-838, 2016 | 834 | 2016 |
| Isolation and in vitro expansion of human colonic stem cells P Jung, T Sato, A Merlos-Suárez, FM Barriga, M Iglesias, D Rossell, ... Nature medicine 17 (10), 1225-1227, 2011 | 810 | 2011 |
| Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis M Huch, P Bonfanti, SF Boj, T Sato, CJM Loomans, M Van De Wetering, ... The EMBO journal 32 (20), 2708-2721, 2013 | 757 | 2013 |
| Visualization and targeting of LGR5+ human colon cancer stem cells M Shimokawa, Y Ohta, S Nishikori, M Matano, A Takano, M Fujii, S Date, ... Nature 545 (7653), 187-192, 2017 | 743 | 2017 |
| Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression T Seino, S Kawasaki, M Shimokawa, H Tamagawa, K Toshimitsu, M Fujii, ... Cell stem cell 22 (3), 454-467. e6, 2018 | 605 | 2018 |
| PTEN-deficient intestinal stem cells initiate intestinal polyposis XC He, T Yin, JC Grindley, Q Tian, T Sato, WA Tao, R Dirisina, ... Nature genetics 39 (2), 189-198, 2007 | 528 | 2007 |
| Current view: intestinal stem cells and signaling DH Scoville, T Sato, XC He, L Li Gastroenterology 134 (3), 849-864, 2008 | 513 | 2008 |
Takanori KanaiVerified email at keio.jp