| Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance J Zhang, X Bu, H Wang, Y Zhu, Y Geng, NT Nihira, Y Tan, Y Ci, F Wu, ... Nature 553 (7686), 91-95, 2018 | 890 | 2018 |
| The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer WC Liang, WM Fu, CW Wong, Y Wang, WM Wang, GX Hu, L Zhang, ... Oncotarget 6 (26), 22513, 2015 | 607 | 2015 |
| PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex P Liu, W Gan, YR Chin, K Ogura, J Guo, J Zhang, B Wang, J Blenis, ... Cancer discovery 5 (11), 1194-1209, 2015 | 451 | 2015 |
| Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway WC Liang, CW Wong, PP Liang, M Shi, Y Cao, ST Rao, SKW Tsui, ... Genome biology 20, 1-12, 2019 | 437 | 2019 |
| Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 X Dai, W Gan, X Li, S Wang, W Zhang, L Huang, S Liu, Q Zhong, J Guo, ... Nature medicine 23 (9), 1063-1071, 2017 | 307 | 2017 |
| MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling J Zhang, W Fu, M He, W Xie, Q Lv, G Wan, G Li, H Wang, G Lu, X Hu, ... RNA biology 8 (5), 829-838, 2011 | 301 | 2011 |
| H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA WC Liang, WM Fu, YB Wang, YX Sun, LL Xu, CW Wong, KM Chan, G Li, ... Scientific reports 6 (1), 20121, 2016 | 269 | 2016 |
| Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway YR Lee, M Chen, JD Lee, J Zhang, SY Lin, TM Fu, H Chen, T Ishikawa, ... Science 364 (6441), eaau0159, 2019 | 266 | 2019 |
| Targeting Cdc20 as a novel cancer therapeutic strategy L Wang, J Zhang, L Wan, X Zhou, Z Wang, W Wei Pharmacology & therapeutics 151, 141-151, 2015 | 247 | 2015 |
| MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix J Zhang, W Fu, M He, H Wang, W Wang, S Yu, XW Bian, J Zhou, MCM Lin, ... Molecular biology of the cell 22 (21), 3955-3961, 2011 | 225 | 2011 |
| SPOP promotes ubiquitination and degradation of the ERG oncoprotein to suppress prostate cancer progression W Gan, X Dai, A Lunardi, Z Li, H Inuzuka, P Liu, S Varmeh, J Zhang, ... Molecular cell 59 (6), 917-930, 2015 | 211 | 2015 |
| Biochemical aspects of PD-L1 regulation in cancer immunotherapy J Zhang, F Dang, J Ren, W Wei Trends in biochemical sciences 43 (12), 1014-1032, 2018 | 208 | 2018 |
| pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner WW d. Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang ... Science 353 (6302), 929-32, 2016 | 198 | 2016 |
| Phosphorylation of EZH2 by AMPK suppresses PRC2 methyltransferase activity and oncogenic function L Wan, K Xu, Y Wei, J Zhang, T Han, C Fry, Z Zhang, YV Wang, L Huang, ... Molecular cell 69 (2), 279-291. e5, 2018 | 186 | 2018 |
| Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling WM Fu, X Zhu, WM Wang, YF Lu, BG Hu, H Wang, WC Liang, SS Wang, ... Journal of hepatology 63 (4), 886-895, 2015 | 182 | 2015 |
| TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling B Wang, Z Jie, D Joo, A Ordureau, P Liu, W Gan, J Guo, J Zhang, BJ North, ... Nature 545 (7654), 365-369, 2017 | 175 | 2017 |
| Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathway J Zhang, G Li, C Chan, C Meng, MC Lin, Y Chen, M He, P Leung, H Kung Molecular and Cellular Endocrinology 314 (1), 70-74, 2010 | 175 | 2010 |
| Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways W Fu, Y Lu, B Hu, W Liang, X Zhu, G Li, J Zhang Oncotarget 7 (4), 4712, 2015 | 161 | 2015 |
| Primate‐specific microRNA‐637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting signal transducer and activator of transcription 3 signaling J Zhang, M He, W Fu, H Wang, L Chen, X Zhu, Y Chen, D Xie, P Lai, ... Hepatology 54 (6), 2137-2148, 2011 | 149 | 2011 |
| LncRNA-NEF antagonized epithelial to mesenchymal transition and cancer metastasis via cis-regulating FOXA2 and inactivating Wnt/β-catenin signaling WC Liang, JL Ren, CW Wong, SO Chan, MMY Waye, WM Fu, JF Zhang Oncogene 37 (11), 1445-1456, 2018 | 129 | 2018 |
Wenyi WeiProfessor, Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolVerified email at bidmc.harvard.edu
