| The many faces of α-synuclein: from structure and toxicity to therapeutic target HA Lashuel, CR Overk, A Oueslati, E Masliah Nature Reviews Neuroscience 14 (1), 38-48, 2013 | 1860 | 2013 |
| Amyloid pores from pathogenic mutations HA Lashuel, D Hartley, BM Petre, T Walz, PT Lansbury Jr Nature 418 (6895), 291-291, 2002 | 1660 | 2002 |
| The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility Y Liu, L Fallon, HA Lashuel, Z Liu, PT Lansbury Cell 111 (2), 209-218, 2002 | 1100 | 2002 |
| α-Synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils HA Lashuel, BM Petre, J Wall, M Simon, RJ Nowak, T Walz, ... Journal of molecular biology 322 (5), 1089-1102, 2002 | 1088 | 2002 |
| A century-old debate on protein aggregation and neurodegeneration enters the clinic PT Lansbury, HA Lashuel Nature 443 (7113), 774-779, 2006 | 823 | 2006 |
| Amyloidogenic protein–membrane interactions: mechanistic insight from model systems SM Butterfield, HA Lashuel Angewandte Chemie International Edition 49 (33), 5628-5654, 2010 | 717 | 2010 |
| α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer B Fauvet, MK Mbefo, MB Fares, C Desobry, S Michael, MT Ardah, E Tsika, ... Journal of Biological Chemistry 287 (19), 15345-15364, 2012 | 691 | 2012 |
| The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration AL Mahul-Mellier, J Burtscher, N Maharjan, L Weerens, M Croisier, ... Proceedings of the National Academy of Sciences 117 (9), 4971-4982, 2020 | 634 | 2020 |
| Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? HA Lashuel, PT Lansbury Quarterly reviews of biophysics 39 (2), 167-201, 2006 | 519 | 2006 |
| Half a century of amyloids: past, present and future PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, ... Chemical Society Reviews 49 (15), 5473-5509, 2020 | 492 | 2020 |
| Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: implications for Parkinson’s disease pathogenesis and therapies A Oueslati, M Fournier, HA Lashuel Progress in brain research 183, 115-145, 2010 | 467 | 2010 |
| Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein KE Paleologou, AW Schmid, CC Rospigliosi, HY Kim, GR Lamberto, ... Journal of Biological Chemistry 283 (24), 16895-16905, 2008 | 457 | 2008 |
| Inhibiting transthyretin amyloid fibril formation via protein stabilization GJ Miroy, Z Lai, HA Lashuel, SA Peterson, C Strang, JW Kelly Proceedings of the National Academy of Sciences 93 (26), 15051-15056, 1996 | 457 | 1996 |
| Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions KE Paleologou, A Oueslati, G Shakked, CC Rospigliosi, HY Kim, ... Journal of Neuroscience 30 (9), 3184-3198, 2010 | 418 | 2010 |
| Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science HA Lashuel, SR LaBrenz, L Woo, LC Serpell, JW Kelly Journal of the American Chemical Society 122 (22), 5262-5277, 2000 | 349 | 2000 |
| Amyloid-β aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability I Allaman, M Gavillet, M Bélanger, T Laroche, D Viertl, HA Lashuel, ... Journal of Neuroscience 30 (9), 3326-3338, 2010 | 339 | 2010 |
| The ratio of monomeric to aggregated forms of Aβ40 and Aβ42 is an important determinant of amyloid-β aggregation, fibrillogenesis, and toxicity A Jan, O Gokce, R Luthi-Carter, HA Lashuel Journal of Biological Chemistry 283 (42), 28176-28189, 2008 | 338 | 2008 |
| Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line Y Liu, HA Lashuel, S Choi, X Xing, A Case, J Ni, LA Yeh, GD Cuny, ... Chemistry & biology 10 (9), 837-846, 2003 | 323 | 2003 |
| Mixtures of wild-type and a pathogenic (E22G) form of Aβ40 in vitro accumulate protofibrils, including amyloid pores HA Lashuel, DM Hartley, BM Petre, JS Wall, MN Simon, T Walz, ... Journal of molecular biology 332 (4), 795-808, 2003 | 316 | 2003 |
| Phosphorylation of synucleins by members of the Polo-like kinase family MK Mbefo, KE Paleologou, A Boucharaba, A Oueslati, H Schell, ... Journal of Biological Chemistry 285 (4), 2807-2822, 2010 | 305 | 2010 |
Abid oueslatiCentre de Recherche du CHU de Québec-Université LavalVerified email at crchudequebec.ulaval.ca