| Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells YC Liu, HY Yen, CY Chen, CH Chen, PF Cheng, YH Juan, CH Chen, ... Proceedings of the National Academy of Sciences 108 (28), 11332-11337, 2011 | 432 | 2011 |
| PtdIns (4, 5) P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling HY Yen, KK Hoi, I Liko, G Hedger, MR Horrell, W Song, D Wu, P Heine, ... Nature 559 (7714), 423-427, 2018 | 279 | 2018 |
| Structural insights into the lipid and ligand regulation of serotonin receptors P Xu, S Huang, H Zhang, C Mao, XE Zhou, X Cheng, IA Simon, DD Shen, ... Nature 592 (7854), 469-473, 2021 | 209 | 2021 |
| Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics CF Tsai, YT Wang, HY Yen, CC Tsou, WC Ku, PY Lin, HY Chen, ... Nature communications 6 (1), 6622, 2015 | 191 | 2015 |
| An electron transfer path connects subunits of a mycobacterial respiratory supercomplex H Gong, J Li, A Xu, Y Tang, W Ji, R Gao, S Wang, L Yu, C Tian, J Li, ... Science 362 (6418), eaat8923, 2018 | 163 | 2018 |
| Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins J Gault, I Liko, M Landreh, D Shutin, JR Bolla, D Jefferies, M Agasid, ... Nature methods 17 (5), 505-508, 2020 | 151 | 2020 |
| Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition HY Yen, YC Liu, NY Chen, CF Tsai, YT Wang, YJ Chen, TL Hsu, PC Yang, ... Proceedings of the National Academy of Sciences 112 (22), 6955-6960, 2015 | 121 | 2015 |
| Differential receptor binding affinities of influenza hemagglutinins on glycan arrays HY Liao, CH Hsu, SC Wang, CH Liang, HY Yen, CY Su, CH Chen, JT Jan, ... Journal of the American Chemical Society 132 (42), 14849-14856, 2010 | 109 | 2010 |
| State-dependent lipid interactions with the A2a receptor revealed by MD simulations using in vivo-mimetic membranes W Song, HY Yen, CV Robinson, MSP Sansom Structure 27 (2), 392-403. e3, 2019 | 108 | 2019 |
| Cell-permeable probe for identification and imaging of sialidases CS Tsai, HY Yen, MI Lin, TI Tsai, SY Wang, WI Huang, TL Hsu, ... Proceedings of the National Academy of Sciences 110 (7), 2466-2471, 2013 | 101 | 2013 |
| Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors LH Urner, I Liko, HY Yen, KK Hoi, JR Bolla, J Gault, FG Almeida, ... Nature communications 11 (1), 564, 2020 | 97 | 2020 |
| Ligand binding to a G protein–coupled receptor captured in a mass spectrometer HY Yen, JTS Hopper, I Liko, TM Allison, Y Zhu, D Wang, M Stegmann, ... Science advances 3 (6), e1701016, 2017 | 74 | 2017 |
| Development of trifunctional probes for glycoproteomic analysis C Tsai, PY Liu, HY Yen, TL Hsu, CH Wong Chemical communications 46 (30), 5575-5577, 2010 | 70 | 2010 |
| Native desorption electrospray ionization liberates soluble and membrane protein complexes from surfaces S Ambrose, NG Housden, K Gupta, J Fan, P White, HY Yen, J Marcoux, ... Angewandte Chemie 129 (46), 14655-14660, 2017 | 61 | 2017 |
| Phosphoproteomics reveals HMGA1, a CK2 substrate, as a drug-resistant target in non-small cell lung cancer YT Wang, SH Pan, CF Tsai, TC Kuo, YL Hsu, HY Yen, WK Choong, ... Scientific reports 7 (1), 44021, 2017 | 41 | 2017 |
| Detergent-free lipodisq nanoparticles facilitate high-resolution mass spectrometry of folded integral membrane proteins KK Hoi, JF Bada Juarez, PJ Judge, HY Yen, D Wu, J Vinals, GF Taylor, ... Nano letters 21 (7), 2824-2831, 2021 | 40 | 2021 |
| Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor HY Yen, I Liko, W Song, P Kapoor, F Almeida, J Toporowska, K Gherbi, ... Nature chemistry 14 (12), 1375-1382, 2022 | 37 | 2022 |
| Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization JF Bada Juarez, PJ Judge, S Adam, D Axford, J Vinals, J Birch, ... Nature Communications 12 (1), 629, 2021 | 37 | 2021 |
| High-throughput native mass spectrometry screening in drug discovery AFM Gavriilidou, K Sokratous, HY Yen, L De Colibus Frontiers in Molecular Biosciences 9, 837901, 2022 | 36 | 2022 |
| Correlating glycoforms of DC‐SIGN with stability using a combination of enzymatic digestion and ion mobility mass spectrometry HY Yen, I Liko, J Gault, D Wu, WB Struwe, CV Robinson Angewandte Chemie 132 (36), 15690-15694, 2020 | 26 | 2020 |