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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2580 | 2019 |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ... Nature genetics 43 (5), 436-441, 2011 | 2244 | 2011 |
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ... Nature genetics 49 (9), 1373-1384, 2017 | 983 | 2017 |
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation ECB Johnson, EB Dammer, DM Duong, L Ping, M Zhou, L Yin, ... Nature medicine 26 (5), 769-780, 2020 | 783 | 2020 |
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions VM Van Deerlin, PMA Sleiman, M Martinez-Lage, A Chen-Plotkin, ... Nature genetics 42 (3), 234-239, 2010 | 639 | 2010 |
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes G Jun, AC Naj, GW Beecham, LS Wang, J Buros, PJ Gallins, JD Buxbaum, ... Archives of neurology 67 (12), 1473-1484, 2010 | 519 | 2010 |
Evidence for brain glucose dysregulation in Alzheimer's disease Y An, VR Varma, S Varma, R Casanova, E Dammer, O Pletnikova, ... Alzheimer's & dementia 14 (3), 318-329, 2018 | 462 | 2018 |
A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer’s disease NT Seyfried, EB Dammer, V Swarup, D Nandakumar, DM Duong, L Yin, ... Cell systems 4 (1), 60-72. e4, 2017 | 435 | 2017 |
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease S Steinberg, H Stefansson, T Jonsson, H Johannsdottir, A Ingason, ... Nature genetics 47 (5), 445-447, 2015 | 388 | 2015 |
Loss of apolipoprotein E receptor LR11 in Alzheimer disease CR Scherzer, K Offe, M Gearing, HD Rees, G Fang, CJ Heilman, ... Archives of neurology 61 (8), 1200-1205, 2004 | 388 | 2004 |
The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease M Wang, ND Beckmann, P Roussos, E Wang, X Zhou, Q Wang, C Ming, ... Scientific data 5 (1), 1-16, 2018 | 382 | 2018 |
Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection L Liao, D Cheng, J Wang, DM Duong, TG Losik, M Gearing, HD Rees, ... Journal of Biological Chemistry 279 (35), 37061-37068, 2004 | 370 | 2004 |
Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease S Palmqvist, H Zetterberg, N Mattsson, P Johansson, ... Neurology 85 (14), 1240-1249, 2015 | 368 | 2015 |
Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease S Rangaraju, EB Dammer, SA Raza, P Rathakrishnan, H Xiao, T Gao, ... Molecular neurodegeneration 13, 1-25, 2018 | 365 | 2018 |
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level ECB Johnson, EK Carter, EB Dammer, DM Duong, ES Gerasimov, Y Liu, ... Nature neuroscience 25 (2), 213-225, 2022 | 363 | 2022 |
The lipoprotein receptor LR11 regulates amyloid β production and amyloid precursor protein traffic in endosomal compartments K Offe, SE Dodson, JT Shoemaker, JJ Fritz, M Gearing, AI Levey, JJ Lah Journal of Neuroscience 26 (5), 1596-1603, 2006 | 336 | 2006 |
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease B Bai, CM Hales, PC Chen, Y Gozal, EB Dammer, JJ Fritz, X Wang, Q Xia, ... Proceedings of the National Academy of Sciences 110 (41), 16562-16567, 2013 | 329 | 2013 |
A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease S Salloway, M Farlow, E McDade, DB Clifford, G Wang, JJ Llibre-Guerra, ... Nature medicine 27 (7), 1187-1196, 2021 | 308 | 2021 |
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly AJ Ho, JL Stein, X Hua, S Lee, DP Hibar, AD Leow, ID Dinov, AW Toga, ... Proceedings of the National Academy of Sciences 107 (18), 8404-8409, 2010 | 305 | 2010 |