| Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors S Hinz, G Navarro, D Borroto-Escuela, BF Seibt, YC Ammon, E De Filippo, ... Oncotarget 9 (17), 13593, 2018 | 103 | 2018 |
| Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925 M Rafehi, JC Burbiel, IY Attah, A Abdelrahman, CE Müller Purinergic signalling 13, 89-103, 2017 | 85 | 2017 |
| Tools and drugs for uracil nucleotide-activated P2Y receptors M Rafehi, CE Müller Pharmacology & Therapeutics 190, 24-80, 2018 | 70 | 2018 |
| Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor M Rafehi, EM Malik, A Neumann, A Abdelrahman, T Hanck, ... Journal of Medicinal Chemistry 60 (7), 3020-3038, 2017 | 50 | 2017 |
| Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor M Rafehi, A Neumann, Y Baqi, EM Malik, M Wiese, V Namasivayam, ... Journal of Medicinal Chemistry 60 (20), 8425-8440, 2017 | 42 | 2017 |
| Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin MAC Corrales, S Zinken, G Konstantinidis, M Rafehi, A Abdelrahman, ... Cell chemical biology 28 (12), 1750-1757. e5, 2021 | 37 | 2021 |
| 8-Substituted 1, 3-dimethyltetrahydropyrazino [2, 1-f] purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors A Brunschweiger, P Koch, M Schlenk, M Rafehi, H Radjainia, P Kueppers, ... Bioorganic & Medicinal Chemistry 24 (21), 5462-5480, 2016 | 31 | 2016 |
| Cell‐permeable high‐affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors M Kuschak, V Namasivayam, M Rafehi, JH Voss, J Garg, JG Schlegel, ... British journal of pharmacology 177 (8), 1898-1916, 2020 | 27 | 2020 |
| Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters O Jensen, M Rafehi, MV Tzvetkov, J Brockmöller Biochemical Pharmacology 171, 113731, 2020 | 25 | 2020 |
| Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A M Rafehi, F Faltraco, J Matthaei, T Prukop, O Jensen, A Grytzmann, ... Frontiers in Pharmacology 10, 1297, 2019 | 25 | 2019 |
| 3-(2-carboxyethyl) indole-2-carboxylic acid derivatives: Structural requirements and properties of potent agonists of the orphan g protein-coupled receptor gpr17 Y Baqi, T Pillaiyar, A Abdelrahman, O Kaufmann, S Alshaibani, M Rafehi, ... Journal of Medicinal Chemistry 61 (18), 8136-8154, 2018 | 25 | 2018 |
| Effects of genetic polymorphism in CYP2D6, CYP2C19, and the organic cation transporter OCT1 on amitriptyline pharmacokinetics in healthy volunteers and depressive disorder patients J Matthaei, J Brockmöller, W Steimer, K Pischa, S Leucht, M Kullmann, ... Frontiers in Pharmacology 12, 688950, 2021 | 24 | 2021 |
| Cellular uptake of psychostimulants–are high-and low-affinity organic cation transporters drug traffickers? O Jensen, M Rafehi, L Gebauer, J Brockmöller Frontiers in Pharmacology 11, 609811, 2021 | 21 | 2021 |
| A novel Huntington’s disease assessment platform to support future drug discovery and development J Wu, L Möhle, T Brüning, I Eiriz, M Rafehi, K Stefan, SM Stefan, J Pahnke International Journal of Molecular Sciences 23 (23), 14763, 2022 | 20 | 2022 |
| Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2 L Gebauer, NA Murugan, O Jensen, J Brockmöller, M Rafehi Biochemical pharmacology 197, 114871, 2022 | 16 | 2022 |
| Ligand binding and activation of UTP-activated G protein-coupled P2Y2 and P2Y4 receptors elucidated by mutagenesis, pharmacological and computational studies IY Attah, A Neumann, H Al-Hroub, M Rafehi, Y Baqi, V Namasivayam, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1864 (3), 129501, 2020 | 16 | 2020 |
| Medicinal polypharmacology: Exploration and exploitation of the polypharmacolome in modern drug development SM Stefan, M Rafehi Drug Development Research 85 (1), e22125, 2024 | 15 | 2024 |
| Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors JH Voss, J Nagel, M Rafehi, R Guixà-González, D Malfacini, J Patt, ... Pharmacological research 173, 105880, 2021 | 15 | 2021 |
| Medicinal Polypharmacology in the Clinic–Translating the Polypharmacolome into Therapeutic Benefit M Rafehi, M Möller, W Ismail Al-Khalil, SM Stefan Pharmaceutical Research 41 (3), 411-417, 2024 | 10 | 2024 |
| The big data challenge–and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond SM Stefan, M Rafehi Neural Regeneration Research 19 (8), 1647-1648, 2024 | 8 | 2024 |