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Ming Xu
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Senolytics improve physical function and increase lifespan in old age
M Xu, T Pirtskhalava, JN Farr, BM Weigand, AK Palmer, MM Weivoda, ...
Nature medicine 24 (8), 1246-1256, 2018
19902018
Targeting cellular senescence prevents age-related bone loss in mice
JN Farr, M Xu, MM Weivoda, DG Monroe, DG Fraser, JL Onken, ...
Nature medicine 23 (9), 1072-1079, 2017
10332017
Fisetin is a senotherapeutic that extends health and lifespan
MJ Yousefzadeh, YI Zhu, SJ McGowan, L Angelini, ...
EBioMedicine 36, 18-28, 2018
8492018
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
M Xu, T Tchkonia, H Ding, M Ogrodnik, ER Lubbers, T Pirtskhalava, ...
Proceedings of the National Academy of Sciences 112 (46), E6301-E6310, 2015
7802015
Targeting senescent cells enhances adipogenesis and metabolic function in old age
M Xu, AK Palmer, H Ding, MM Weivoda, T Pirtskhalava, TA White, A Sepe, ...
elife 4, e12997, 2015
5832015
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
AK Palmer, M Xu, YI Zhu, T Pirtskhalava, MM Weivoda, CM Hachfeld, ...
Aging cell 18 (3), e12950, 2019
5402019
Obesity-induced cellular senescence drives anxiety and impairs neurogenesis
M Ogrodnik, YI Zhu, LGP Langhi, T Tchkonia, P Krüger, E Fielder, ...
Cell metabolism 29 (5), 1061-1077. e8, 2019
4882019
Cellular senescence in type 2 diabetes: a therapeutic opportunity
AK Palmer, T Tchkonia, NK LeBrasseur, EN Chini, M Xu, JL Kirkland
Diabetes 64 (7), 2289-2298, 2015
4552015
Transplanted senescent cells induce an osteoarthritis-like condition in mice
M Xu, EW Bradley, MM Weivoda, SM Hwang, T Pirtskhalava, T Decklever, ...
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2017
3842017
Strategies for targeting senescent cells in human disease
NS Gasek, GA Kuchel, JL Kirkland, M Xu
Nature aging 1 (10), 870-879, 2021
3642021
The heterogeneity of cellular senescence: insights at the single-cell level
RL Cohn, NS Gasek, GA Kuchel, M Xu
Trends in cell biology 33 (1), 9-17, 2023
1562023
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
L Wang, B Wang, NS Gasek, Y Zhou, RL Cohn, DE Martin, W Zuo, ...
Cell metabolism 34 (1), 75-89. e8, 2022
1372022
17α-Estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization
MB Stout, FJ Steyn, MJ Jurczak, JPG Camporez, YI Zhu, JR Hawse, ...
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2017
1192017
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo
B Wang, L Wang, NS Gasek, Y Zhou, T Kim, C Guo, ER Jellison, ...
Nature aging 1 (10), 962-973, 2021
1132021
Post‐translational modification of POU domain transcription factor Oct‐4 by SUMO‐1
Z Zhang, B Liao, M Xu, Y Jin
The FASEB Journal 21 (12), 3042-3051, 2007
812007
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
Brown University TDA Wang Siyuan (Steven) 34, ...
Nature aging 2 (12), 1090-1100, 2022
772022
Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction
M Xu, T Tchkonia, JL Kirkland
Pharmacological Research 111, 152-154, 2016
732016
Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling
LR Carpio, EW Bradley, ME McGee-Lawrence, MM Weivoda, DD Poston, ...
Science signaling 9 (440), ra79-ra79, 2016
712016
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia
S Suvakov, H Cubro, WM White, YS Butler Tobah, TL Weissgerber, ...
Biology of sex differences 10, 1-13, 2019
692019
SenNet recommendations for detecting senescent cells in different tissues
V Suryadevara, AD Hudgins, A Rajesh, A Pappalardo, A Karpova, AK Dey, ...
Nature Reviews Molecular Cell Biology, 1-23, 2024
662024
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