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Targeting cellular senescence prevents age-related bone loss in mice JN Farr, M Xu, MM Weivoda, DG Monroe, DG Fraser, JL Onken, ... Nature medicine 23 (9), 1072-1079, 2017 | 1033 | 2017 |
Fisetin is a senotherapeutic that extends health and lifespan MJ Yousefzadeh, YI Zhu, SJ McGowan, L Angelini, ... EBioMedicine 36, 18-28, 2018 | 849 | 2018 |
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age M Xu, T Tchkonia, H Ding, M Ogrodnik, ER Lubbers, T Pirtskhalava, ... Proceedings of the National Academy of Sciences 112 (46), E6301-E6310, 2015 | 780 | 2015 |
Targeting senescent cells enhances adipogenesis and metabolic function in old age M Xu, AK Palmer, H Ding, MM Weivoda, T Pirtskhalava, TA White, A Sepe, ... elife 4, e12997, 2015 | 583 | 2015 |
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction AK Palmer, M Xu, YI Zhu, T Pirtskhalava, MM Weivoda, CM Hachfeld, ... Aging cell 18 (3), e12950, 2019 | 540 | 2019 |
Obesity-induced cellular senescence drives anxiety and impairs neurogenesis M Ogrodnik, YI Zhu, LGP Langhi, T Tchkonia, P Krüger, E Fielder, ... Cell metabolism 29 (5), 1061-1077. e8, 2019 | 488 | 2019 |
Cellular senescence in type 2 diabetes: a therapeutic opportunity AK Palmer, T Tchkonia, NK LeBrasseur, EN Chini, M Xu, JL Kirkland Diabetes 64 (7), 2289-2298, 2015 | 455 | 2015 |
Transplanted senescent cells induce an osteoarthritis-like condition in mice M Xu, EW Bradley, MM Weivoda, SM Hwang, T Pirtskhalava, T Decklever, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2017 | 384 | 2017 |
Strategies for targeting senescent cells in human disease NS Gasek, GA Kuchel, JL Kirkland, M Xu Nature aging 1 (10), 870-879, 2021 | 364 | 2021 |
The heterogeneity of cellular senescence: insights at the single-cell level RL Cohn, NS Gasek, GA Kuchel, M Xu Trends in cell biology 33 (1), 9-17, 2023 | 156 | 2023 |
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity L Wang, B Wang, NS Gasek, Y Zhou, RL Cohn, DE Martin, W Zuo, ... Cell metabolism 34 (1), 75-89. e8, 2022 | 137 | 2022 |
17α-Estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization MB Stout, FJ Steyn, MJ Jurczak, JPG Camporez, YI Zhu, JR Hawse, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2017 | 119 | 2017 |
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo B Wang, L Wang, NS Gasek, Y Zhou, T Kim, C Guo, ER Jellison, ... Nature aging 1 (10), 962-973, 2021 | 113 | 2021 |
Post‐translational modification of POU domain transcription factor Oct‐4 by SUMO‐1 Z Zhang, B Liao, M Xu, Y Jin The FASEB Journal 21 (12), 3042-3051, 2007 | 81 | 2007 |
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health Brown University TDA Wang Siyuan (Steven) 34, ... Nature aging 2 (12), 1090-1100, 2022 | 77 | 2022 |
Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction M Xu, T Tchkonia, JL Kirkland Pharmacological Research 111, 152-154, 2016 | 73 | 2016 |
Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling LR Carpio, EW Bradley, ME McGee-Lawrence, MM Weivoda, DD Poston, ... Science signaling 9 (440), ra79-ra79, 2016 | 71 | 2016 |
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia S Suvakov, H Cubro, WM White, YS Butler Tobah, TL Weissgerber, ... Biology of sex differences 10, 1-13, 2019 | 69 | 2019 |
SenNet recommendations for detecting senescent cells in different tissues V Suryadevara, AD Hudgins, A Rajesh, A Pappalardo, A Karpova, AK Dey, ... Nature Reviews Molecular Cell Biology, 1-23, 2024 | 66 | 2024 |