| Structural basis of PROTAC cooperative recognition for selective protein degradation MS Gadd, A Testa, X Lucas, KH Chan, W Chen, DJ Lamont, M Zengerle, ... Nature chemical biology 13 (5), 514-521, 2017 | 1090 | 2017 |
| A thorough anion–π interaction study in biomolecules: on the importance of cooperativity effects X Lucas, A Bauzá, A Frontera, D Quinonero Chemical science 7 (2), 1038-1050, 2016 | 216 | 2016 |
| Structure‐Based Design of a Macrocyclic PROTAC A Testa, SJ Hughes, X Lucas, JE Wright, A Ciulli Angewandte Chemie 132 (4), 1744-1751, 2020 | 209 | 2020 |
| StreptomeDB: a resource for natural compounds isolated from Streptomyces species X Lucas, C Senger, A Erxleben, BA Grüning, K Döring, J Mosch, ... Nucleic acids research 41 (D1), D1130-D1136, 2012 | 155 | 2012 |
| Development and Benchmarking of Open Force Field v1. 0.0—the Parsley Small-Molecule Force Field Y Qiu, DGA Smith, S Boothroyd, H Jang, DF Hahn, J Wagner, CC Bannan, ... Journal of chemical theory and computation 17 (10), 6262-6280, 2021 | 151 | 2021 |
| 3-Fluoro-4-hydroxyprolines: synthesis, conformational analysis, and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation A Testa, X Lucas, GV Castro, KH Chan, JE Wright, AC Runcie, MS Gadd, ... Journal of the American Chemical Society 140 (29), 9299-9313, 2018 | 140 | 2018 |
| 4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading X Lucas, D Wohlwend, M Hügle, K Schmidtkunz, S Gerhardt, R Schüle, ... Angewandte Chemie International Edition 52 (52), 14055-9, 2013 | 131 | 2013 |
| StreptomeDB 2.0—an extended resource of natural products produced by streptomycetes D Klementz, K Döring, X Lucas, KK Telukunta, A Erxleben, D Deubel, ... Nucleic acids research 44 (D1), D509-D514, 2016 | 111 | 2016 |
| Very long‐range effects: cooperativity between anion–π and hydrogen‐bonding interactions X Lucas, C Estarellas, D Escudero, A Frontera, D Quiñonero, PM Deyà ChemPhysChem 10 (13), 2256-2264, 2009 | 95 | 2009 |
| Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies X Lucas, A Ciulli Current opinion in structural biology 44, 101-110, 2017 | 88 | 2017 |
| Virtual screening strategies in drug design–methods and applications E Bielska, X Lucas, A Czerwoniec, JM Kasprzak, KH Kamińska, ... Biotechnologia 92 (3), 249-64, 2011 | 84 | 2011 |
| 4-Acyl pyrrole derivatives yield novel vectors for designing inhibitors of the acetyl-lysine recognition site of BRD4 (1) M Hügle, X Lucas, G Weitzel, D Ostrovskyi, B Breit, S Gerhardt, O Einsle, ... Journal of medicinal chemistry 59 (4), 1518-1530, 2016 | 65 | 2016 |
| The Purchasable Chemical Space: a Detailed Picture X Lucas, BA Grüning, S Bleher, S Günther Journal of Chemical Information and Modeling, 2015 | 49 | 2015 |
| Counterintuitive Substituent Effect of the Ethynyl Group in Ion− π Interactions X Lucas, D Quinonero, A Frontera, PM Deya The Journal of Physical Chemistry A 113 (38), 10367-10375, 2009 | 43 | 2009 |
| The ChemicalToolbox: reproducible, user-friendly cheminformatics analysis on the Galaxy platform SA Bray, X Lucas, A Kumar, BA Grüning Journal of Cheminformatics 12 (1), 40, 2020 | 41 | 2020 |
| Beyond the BET family: targeting CBP/p300 with 4‐acyl pyrroles M Hügle, X Lucas, D Ostrovskyi, P Regenass, S Gerhardt, O Einsle, ... Angewandte Chemie International Edition 56 (41), 12476-12480, 2017 | 39 | 2017 |
| Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains A Bortoluzzi, A Amato, X Lucas, M Blank, A Ciulli Biochemical Journal 474 (10), 1633-1651, 2017 | 37 | 2017 |
| Surface probing by fragment-based screening and computational methods identifies ligandable pockets on the von Hippel–Lindau (VHL) E3 ubiquitin ligase X Lucas, I Van Molle, A Ciulli Journal of medicinal chemistry 61 (16), 7387-7393, 2018 | 35 | 2018 |
| Targeting ligandable pockets on plant homeodomain (PHD) zinc finger domains by a fragment-based approach A Amato, X Lucas, A Bortoluzzi, D Wright, A Ciulli ACS chemical biology 13 (4), 915-921, 2018 | 31 | 2018 |
| Target fishing by cross‐docking to explain polypharmacological effects H Patel, X Lucas, I Bendik, S Günther, I Merfort ChemMedChem 10 (7), 1209-1217, 2015 | 28 | 2015 |
Stefan GüntherProfessor for Pharmaceutical Bioinformatics, Freiburg UniversityVerified email at pharmazie.uni-freiburg.de