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The shedding protease ADAM17: Physiology and pathophysiology F Zunke, S Rose-John Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (11), 2059-2070, 2017 | 342 | 2017 |
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36 D Neculai, M Schwake, M Ravichandran, F Zunke, RF Collins, J Peters, ... Nature 504 (7478), 172-176, 2013 | 339 | 2013 |
Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson's patient midbrain neurons JR Mazzulli, F Zunke, T Tsunemi, NJ Toker, S Jeon, LF Burbulla, ... Journal of Neuroscience 36 (29), 7693-7706, 2016 | 290 | 2016 |
Reversible conformational conversion of α-synuclein into toxic assemblies by glucosylceramide F Zunke, AC Moise, NR Belur, E Gelyana, I Stojkovska, H Dzaferbegovic, ... Neuron 97 (1), 92-107. e10, 2018 | 239 | 2018 |
Detection of neuron-derived pathological α-synuclein in blood A Kluge, J Bunk, E Schaeffer, A Drobny, W Xiang, H Knacke, S Bub, ... Brain 145 (9), 3058-3071, 2022 | 165 | 2022 |
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance M Rothaug, F Zunke, JR Mazzulli, M Schweizer, H Altmeppen, ... Proceedings of the National Academy of Sciences 111 (43), 15573-15578, 2014 | 145 | 2014 |
Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor–mediated relaxation of renal arteries in hypertension PS Chadha, F Zunke, HL Zhu, AJ Davis, TA Jepps, SP Olesen, WC Cole, ... Hypertension 59 (4), 877-884, 2012 | 132 | 2012 |
α-Synuclein in Parkinson’s disease: causal or bystander? P Riederer, D Berg, N Casadei, F Cheng, J Classen, C Dresel, W Jost, ... Journal of neural transmission 126, 815-840, 2019 | 113 | 2019 |
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease M Rothaug, S Stroobants, M Schweizer, J Peters, F Zunke, M Allerding, ... Acta neuropathologica communications 3, 1-17, 2015 | 85 | 2015 |
Alpha synuclein connects the gut-brain axis in Parkinson’s disease patients–a view on clinical aspects, cellular pathology and analytical methodology E Schaeffer, A Kluge, M Böttner, F Zunke, F Cossais, D Berg, P Arnold Frontiers in cell and developmental biology 8, 573696, 2020 | 76 | 2020 |
Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking I Stojkovska, WY Wani, F Zunke, NR Belur, EA Pavlenko, N Mwenda, ... Neuron 110 (3), 436-451. e11, 2022 | 75 | 2022 |
ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling S Schmidt, N Schumacher, J Schwarz, S Tangermann, L Kenner, ... Journal of Experimental Medicine 215 (4), 1205-1225, 2018 | 74 | 2018 |
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2 F Zunke, L Andresen, S Wesseler, J Groth, P Arnold, M Rothaug, ... Proceedings of the National Academy of Sciences 113 (14), 3791-3796, 2016 | 74 | 2016 |
Stress-induced cellular clearance is mediated by the SNARE protein ykt6 and disrupted by α-Synuclein LK Cuddy, WY Wani, ML Morella, C Pitcairn, K Tsutsumi, K Fredriksen, ... Neuron 104 (5), 869-884. e11, 2019 | 68 | 2019 |
Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries PS Chadha, F Zunke, AJ Davis, TA Jepps, JTM Linders, M Schwake, ... British journal of pharmacology 166 (4), 1377-1387, 2012 | 68 | 2012 |
The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches A Drobny, SP Huarcaya, J Dobert, A Kluge, J Bunk, T Schlothauer, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1869 (7), 119243, 2022 | 53 | 2022 |
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Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models S Prieto Huarcaya, A Drobny, ARA Marques, A Di Spiezio, JP Dobert, ... Autophagy 18 (5), 1127-1151, 2022 | 47 | 2022 |
Mutations in the B. 1.1. 7 SARS-CoV-2 spike protein reduce receptor-binding affinity and induce a flexible link to the fusion peptide E Socher, M Conrad, L Heger, F Paulsen, H Sticht, F Zunke, P Arnold Biomedicines 9 (5), 525, 2021 | 42 | 2021 |