Human iPSC-derived blood-brain barrier chips enable disease modeling and personalized medicine applications GD Vatine, R Barrile, MJ Workman, S Sances, BK Barriga, M Rahnama, ... Cell stem cell 24 (6), 995-1005. e6, 2019 | 542 | 2019 |
Modeling ALS with motor neurons derived from human induced pluripotent stem cells S Sances, LI Bruijn, S Chandran, K Eggan, R Ho, JR Klim, MR Livesey, ... Nature neuroscience 19 (4), 542-553, 2016 | 330 | 2016 |
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery A Sharma, S Sances, MJ Workman, CN Svendsen Cell stem cell 26 (3), 309-329, 2020 | 260 | 2020 |
Human iPSC-derived endothelial cells and microengineered organ-chip enhance neuronal development S Sances, R Ho, G Vatine, D West, A Laperle, A Meyer, M Godoy, PS Kay, ... Stem cell reports 10 (4), 1222-1236, 2018 | 164 | 2018 |
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates AH Laperle, S Sances, N Yucer, VJ Dardov, VJ Garcia, R Ho, AN Fulton, ... Nature medicine 26 (2), 289-299, 2020 | 125 | 2020 |
ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks R Ho, S Sances, G Gowing, MW Amoroso, JG O'Rourke, A Sahabian, ... Nature neuroscience 19 (9), 1256-1267, 2016 | 113 | 2016 |
Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease L Amirifar, A Shamloo, R Nasiri, NR de Barros, ZZ Wang, BD Unluturk, ... Biomaterials 285, 121531, 2022 | 92 | 2022 |
Organoid and organ-on-a-chip systems: new paradigms for modeling neurological and gastrointestinal disease AA Akhtar, S Sances, R Barrett, JJ Breunig Current stem cell reports 3, 98-111, 2017 | 30 | 2017 |
Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells M Mozneb, A Jenkins, S Sances, S Pohlman, MJ Workman, D West, ... Lab on a Chip 24 (4), 869-881, 2024 | 11 | 2024 |
Development of spinal cord on a microfluidic chip SJ Kerns, N Wen, C Lucchesi, CD Hinojosa, J Fraser, G Hamilton, ... US Patent 12,091,650, 2024 | 10 | 2024 |
Tissue clearing of human iPSC-derived organ-chips enables high resolution imaging and analysis BN Ondatje, S Sances, MJ Workman, CN Svendsen Lab on a Chip 22 (21), 4246-4255, 2022 | 7 | 2022 |
Microfluidic model of the blood brain barrier SJ Kerns, N Wen, C Lucchesi, CD Hinojosa, J Fraser, G Hamilton, ... US Patent 11,174,462, 2021 | 7 | 2021 |
Microfluidic model of the blood brain barrier SJ Kerns, N Wen, C Lucchesi, CD Hinojosa, J Fraser, G Hamilton, ... US Patent App. 15/768,736, 2018 | 7 | 2018 |
Microfluidic Model of the Blood Brain Barrier SJ Kerns, N Wen, C Lucchesi, CD Hinojosa, J Fraser, G Hamilton, ... US Patent App. 15/955,383, 2018 | 7 | 2018 |
Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip S Sances, A Laperle, N Yucer, CN Svendsen US Patent App. 17/041,672, 2021 | 6 | 2021 |
Diagnostic and drug screening for molecular signatures of early onset sporadic parkinson's disease A Laperle, S Sances, N Yucer, CN Svendsen US Patent App. 17/043,272, 2021 | 6 | 2021 |
Pkc pathway in parkinson's disease A Laperle, S Sances, N Yucer, CN Svendsen US Patent App. 17/043,344, 2021 | 6 | 2021 |
Deep Learning Analysis on Images of iPSC-derived Motor Neurons Carrying fALS-genetics Reveals Disease-Relevant Phenotypes R Atmaramani, T Dreossi, K Ford, L Gan, J Mitchell, S Tu, J Velayutham, ... bioRxiv, 2024.01. 04.574270, 2024 | 5 | 2024 |
Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells A Laperle, S Sances, N Yucer, CN Svendsen US Patent 11,981,918, 2024 | 4 | 2024 |
Multi-lineage cardiovascular microfluidic organ-chip A Sharma, S Sances, C Svendsen US Patent App. 17/921,217, 2023 | 4 | 2023 |