| C9orf72 expansion disrupts ATM-mediated chromosomal break repair C Walker, S Herranz-Martin, E Karyka, C Liao, K Lewis, W Elsayed, ... Nature neuroscience 20 (9), 1225-1235, 2017 | 198 | 2017 |
| Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade E Bonavita, CP Bromley, G Jonsson, VS Pelly, S Sahoo, K Walwyn-Brown, ... Immunity 53 (6), 1215-1229. e8, 2020 | 194 | 2020 |
| Anti-inflammatory drugs remodel the tumor immune environment to enhance immune checkpoint blockade efficacy VS Pelly, A Moeini, LM Roelofsen, E Bonavita, CR Bell, C Hutton, ... Cancer discovery 11 (10), 2602-2619, 2021 | 132 | 2021 |
| TEX264 coordinates p97-and SPRTN-mediated resolution of topoisomerase 1-DNA adducts J Fielden, K Wiseman, I Torrecilla, S Li, S Hume, SC Chiang, A Ruggiano, ... Nature communications 11 (1), 1274, 2020 | 99 | 2020 |
| SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair JJR Hudson, SC Chiang, OS Wells, C Rookyard, SF El-Khamisy Nature communications 3 (1), 733, 2012 | 97 | 2012 |
| Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks C Kerzendorfer, A Whibley, G Carpenter, E Outwin, SC Chiang, G Turner, ... Human molecular genetics 19 (7), 1324-1334, 2010 | 81 | 2010 |
| ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells M Alagoz, SC Chiang, A Sharma, SF El-Khamisy PloS one 8 (4), e58239, 2013 | 80 | 2013 |
| TDP1 serine 81 promotes interaction with DNA ligase IIIα and facilitates cell survival following DNA damage SC Chiang, J Carroll, SF El-Khamisy Cell Cycle 9 (3), 588-595, 2010 | 79 | 2010 |
| Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations CR Bell, VS Pelly, A Moeini, SC Chiang, E Flanagan, CP Bromley, ... Nature communications 13 (1), 2063, 2022 | 69 | 2022 |
| Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage SC Chiang, M Meagher, N Kassouf, M Hafezparast, PJ McKinnon, ... Science advances 3 (4), e1602506, 2017 | 65 | 2017 |
| UCHL3 regulates topoisomerase-induced chromosomal break repair by controlling TDP1 proteostasis C Liao, R Beveridge, JJR Hudson, JD Parker, SC Chiang, S Ray, ... Cell reports 23 (11), 3352-3365, 2018 | 53 | 2018 |
| Identification and characterisation of the BPI/LBP/PLUNC-like gene repertoire in chickens reveals the absence of a LBP gene SC Chiang, EJA Veldhuizen, FA Barnes, CJ Craven, HP Haagsman, ... Developmental & Comparative Immunology 35 (3), 285-295, 2011 | 43 | 2011 |
| Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing J Carroll, TKW Page, SC Chiang, B Kalmar, D Bode, L Greensmith, ... Human molecular genetics 24 (3), 828-840, 2015 | 21 | 2015 |
| Study of the mechanisms of crocetin‐induced differentiation and apoptosis in human acute promyelocytic leukemia cells M Moradzadeh, A Ghorbani, S Erfanian, ST Mohaddes, H Rahimi, ... Journal of cellular biochemistry 120 (2), 1943-1957, 2019 | 17 | 2019 |
| UVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy N Kassouf, CWM Kay, A Volkov, SC Chiang, MA Birch-Machin, ... Free Radical Biology and Medicine 126, 153-165, 2018 | 5 | 2018 |
| Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations. Nat Commun. 2022; 13: 2063 CR Bell, VS Pelly, A Moeini, SC Chiang, E Flanagan, CP Bromley, ... DOI: https://doi. org/10.1038/s41467-022-29606-9. PMID: https://www. ncbi …, 0 | 5 | |
| Studying TDP1 function in DNA repair SC Chiang, K Liversidge, SF El-Khamisy DNA Topoisomerases: Methods and Protocols, 173-181, 2018 | 4 | 2018 |
| Evolutionary History of PLUNCs: The Putative Pulmonary Mucosal Host Defence Proteins, SPLUNC1 and LPLUNC1 Are Present Only in the Therian Lineage. CD Bingle, S Chiang, EJ Veldhuizen, HP Haagsman, L Bingle, CJ Craven B32. MUCOSAL IMMUNITY AND AIRWAY EPITHELIA, A2816, 2009 | 1 | 2009 |
| Topical corticosteroids stimulate T cell-dependent melanoma growth control CH Earnshaw, SC Chiang, A Moeini, M Koufaki, E Bonavita, L Nebot-Bral, ... Cancer Research 84 (6_Supplement), 2647-2647, 2024 | | 2024 |
| 1254 Topical corticosteroids stimulate T cell-dependent melanoma growth control C Earnshaw, A Moeini, S Chiang, E Bonavita, M Koufaki, C Griffiths, ... Journal of Investigative Dermatology 143 (5), S215, 2023 | | 2023 |
Abhishek Bharadwaj SharmaUniversity of OxfordVerified email at bioch.ox.ac.uk