| The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’system? NJ Abbott, ME Pizzo, JE Preston, D Janigro, RG Thorne Acta neuropathologica 135, 387-407, 2018 | 630 | 2018 |
| Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne Journal of Cerebral Blood Flow & Metabolism 35 (3), 371-381, 2015 | 285 | 2015 |
| Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ... Science translational medicine 12 (545), eaay1359, 2020 | 266 | 2020 |
| Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery ME Pizzo, DJ Wolak, NN Kumar, E Brunette, CL Brunnquell, MJ Hannocks, ... The Journal of physiology 596 (3), 445-475, 2018 | 261 | 2018 |
| Molecular characterization of perivascular drainage pathways in the murine brain MJ Hannocks, ME Pizzo, J Huppert, T Deshpande, NJ Abbott, RG Thorne, ... Journal of Cerebral Blood Flow & Metabolism 38 (4), 669-686, 2018 | 174 | 2018 |
| Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ... Cell 184 (18), 4651-4668. e25, 2021 | 154 | 2021 |
| A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models B van Lengerich, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, ... Nature neuroscience 26 (3), 416-429, 2023 | 143 | 2023 |
| Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery NN Kumar, JJ Lochhead, ME Pizzo, G Nehra, S Boroumand, G Greene, ... Journal of Controlled Release 286, 467-484, 2018 | 96 | 2018 |
| Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging DJ Wolak, ME Pizzo, RG Thorne Journal of Controlled Release 197, 78-86, 2015 | 88 | 2015 |
| Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia D Xia, S Lianoglou, T Sandmann, M Calvert, JH Suh, E Thomsen, ... Molecular neurodegeneration 17 (1), 41, 2022 | 70 | 2022 |
| Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme A Arguello, CS Mahon, MEK Calvert, D Chan, JC Dugas, ME Pizzo, ... Journal of Experimental Medicine 219 (3), e20211057, 2022 | 60 | 2022 |
| Passive immunotherapies for central nervous system disorders: current delivery challenges and new approaches NN Kumar, ME Pizzo, G Nehra, B Wilken-Resman, S Boroumand, ... Bioconjugate chemistry 29 (12), 3937-3966, 2018 | 38 | 2018 |
| CD98hc is a target for brain delivery of biotherapeutics KS Chew, RC Wells, A Moshkforoush, D Chan, KJ Lechtenberg, HL Tran, ... nature communications 14 (1), 5053, 2023 | 33 | 2023 |
| Osmotic enhancement of drug/therapeutic delivery to the brain following infusion or injection into the cerebrospinal fluid RG Thorne, ME Pizzo, DJ Wolak US Patent 10,123,969, 2018 | 33 | 2018 |
| Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier SJ Barker, MB Thayer, C Kim, D Tatarakis, MJ Simon, R Dial, L Nilewski, ... Science Translational Medicine 16 (760), eadi2245, 2024 | 25 | 2024 |
| The extracellular and perivascular spaces of the brain ME Pizzo, RG Thorne Brain edema, 105-127, 2017 | 16 | 2017 |
| Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model D Xia, S Lianoglou, T Sandmann, M Calvert, JH Suh, E Thomsen, ... bioRxiv, 2021.01. 19.426731, 2021 | 8 | 2021 |
| Visible and sub-visible particle formation for a model bioconjugate LM Lewis, ME Pizzo, S Sinha, SS Ahmed, L Joseph AAPS PharmSciTech 18 (3), 926-931, 2017 | 5 | 2017 |
| Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIA ME Pizzo, ED Plowey, N Khoury, W Kwan, J Abettan, SL DeVos, ... bioRxiv, 2024.07. 26.604664, 2024 | 3 | 2024 |
| Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ... Cell 187 (6), 1565, 2024 | 3 | 2024 |