| The clinical KRAS (G12C) inhibitor AMG 510 drives anti-tumour immunity J Canon, K Rex, AY Saiki, C Mohr, K Cooke, D Bagal, K Gaida, T Holt, ... Nature 575 (7781), 217-223, 2019 | 1991 | 2019 |
| Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors BA Lanman, JR Allen, JG Allen, AK Amegadzie, KS Ashton, SK Booker, ... Journal of medicinal chemistry 63 (1), 52-65, 2019 | 601 | 2019 |
| Synthesis of highly epimerizable N-protected α-amino aldehydes of high enantiomeric excess AG Myers, B Zhong, M Movassaghi, DW Kung, BA Lanman, S Kwon Tetrahedron Letters 41 (9), 1359-1362, 2000 | 134 | 2000 |
| A solid-supported, enantioselective synthesis suitable for the rapid preparation of large numbers of diverse structural analogues of (−)-saframycin A AG Myers, BA Lanman Journal of the American Chemical Society 124 (44), 12969-12971, 2002 | 93 | 2002 |
| On the structure of palau'amine: Evidence for the revised relative configuration from chemical synthesis BA Lanman, LE Overman, R Paulini, NS White Journal of the American Chemical Society 129 (42), 12896-12900, 2007 | 90 | 2007 |
| Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C Y Shin, JW Jeong, RP Wurz, P Achanta, T Arvedson, MD Bartberger, ... ACS medicinal chemistry letters 10 (9), 1302-1308, 2019 | 87 | 2019 |
| Efficient, Stereoselective Synthesis of trans-2,5-Disubstituted Morpholines BA Lanman, AG Myers Organic Letters 6 (6), 1045-1047, 2004 | 82 | 2004 |
| Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5 VJ Cee, M Frohn, BA Lanman, J Golden, K Muller, S Neira, A Pickrell, ... ACS Medicinal Chemistry Letters 2 (2), 107-112, 2011 | 66 | 2011 |
| Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases AL Smith, ND D’Angelo, YY Bo, SK Booker, VJ Cee, B Herberich, ... Journal of medicinal chemistry 55 (11), 5188-5219, 2012 | 55 | 2012 |
| KRAS G12C inhibitors and methods of using the same BA Lanman, J Chen, AB Reed, VJ Cee, L Liu, DJ Kopecky, P Lopez, ... US Patent 10,519,146, 2019 | 52 | 2019 |
| Inhibitors of PI3 kinase and/or mTOR N D'angelo, FT Hong, MH Norman, AL Smith, S Tadesse US Patent 8,362,241, 2013 | 52* | 2013 |
| KRAS G12C inhibitors and methods of using the same JG Allen, JR Allen, AE Minatti, Q Xue, RP Wurz, CM Tegley, AJ Pickrell, ... US Patent 11,090,304, 2021 | 48 | 2021 |
| Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511 MH Norman, KL Andrews, YY Bo, SK Booker, S Caenepeel, VJ Cee, ... Journal of medicinal chemistry 55 (17), 7796-7816, 2012 | 48 | 2012 |
| KRAS G12C inhibitors and methods of using the same BA Lanman, VJ Cee, AJ Pickrell, AB Reed, KC Yang, DJ Kopecky, ... US Patent 10,532,042, 2020 | 47 | 2020 |
| Addressing atropisomerism in the development of sotorasib, a covalent inhibitor of KRAS G12C: structural, analytical, and synthetic considerations BA Lanman, AT Parsons, SG Zech Accounts of Chemical Research 55 (20), 2892-2903, 2022 | 42 | 2022 |
| The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors HL Wang, VJ Cee, F Chavez Jr, BA Lanman, AB Reed, B Wu, N Guerrero, ... Bioorganic & medicinal chemistry letters 25 (4), 834-840, 2015 | 42 | 2015 |
| Discovery and optimization of quinazolinone-pyrrolopyrrolones as potent and orally bioavailable pan-pim kinase inhibitors LH Pettus, KL Andrews, SK Booker, J Chen, VJ Cee, F Chavez Jr, Y Chen, ... Journal of medicinal chemistry 59 (13), 6407-6430, 2016 | 40 | 2016 |
| Discovery of (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one, a … HL Wang, KL Andrews, SK Booker, J Canon, VJ Cee, F Chavez Jr, ... Journal of Medicinal Chemistry 62 (3), 1523-1540, 2019 | 36 | 2019 |
| Bicyclic compounds as Pim inhibitors HL Wang, K Biswas, VJ Cee, F Chavez Jr, BJ Herberich, CLM Jackson, ... US Patent 9,090,593, 2015 | 36 | 2015 |
| Inhibitors of KRAS G12C and methods of using the same BA Lanman, S Booker, C Goodman, AB Reed, JD Low, HL Wang, N Chen, ... US Patent 10,640,504, 2020 | 35 | 2020 |
