| A global genetic interaction network maps a wiring diagram of cellular function M Costanzo, B VanderSluis, EN Koch, A Baryshnikova, C Pons, G Tan, ... Science 353 (6306), aaf1420, 2016 | 1345 | 2016 |
| Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ... G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017 | 555 | 2017 |
| Systematic analysis of complex genetic interactions E Kuzmin, B VanderSluis, W Wang, G Tan, R Deshpande, Y Chen, M Usaj, ... Science 360 (6386), eaao1729, 2018 | 295 | 2018 |
| Global genetic networks and the genotype-to-phenotype relationship M Costanzo, E Kuzmin, J van Leeuwen, B Mair, J Moffat, C Boone, ... Cell 177 (1), 85-100, 2019 | 226 | 2019 |
| Exploring genetic suppression interactions on a global scale J Van Leeuwen, C Pons, JC Mellor, TN Yamaguchi, H Friesen, ... Science 354 (6312), aag0839, 2016 | 190 | 2016 |
| Exploring whole-genome duplicate gene retention with complex genetic interaction analysis E Kuzmin, B VanderSluis, AN Nguyen Ba, W Wang, EN Koch, M Usaj, ... Science 368 (6498), eaaz5667, 2020 | 102 | 2020 |
| Functional annotation of chemical libraries across diverse biological processes JS Piotrowski, SC Li, R Deshpande, SW Simpkins, J Nelson, Y Yashiroda, ... Nature Chemical Biology 13 (9), 982-993, 2017 | 94 | 2017 |
| Metabolism related toxicity of diclofenac in yeast as model system JS van Leeuwen, G Vredenburg, S Dragovic, TFJ Tjong, JC Vos, ... Toxicology letters 200 (3), 162-168, 2011 | 59 | 2011 |
| Systematic analysis of bypass suppression of essential genes J Van Leeuwen, C Pons, G Tan, ZY Wang, J Hou, J Weile, M Gebbia, ... Molecular systems biology 16 (9), 1-24, 2020 | 54 | 2020 |
| Rapid and efficient plasmid construction by homologous recombination in yeast J van Leeuwen, B Andrews, C Boone, G Tan Cold Spring Harbor Protocols 2015 (9), pdb. prot085100, 2015 | 53 | 2015 |
| Mechanisms of suppression: The wiring of genetic resilience J van Leeuwen, C Pons, C Boone, BJ Andrews BioEssays 39 (7), 1700042, 2017 | 52 | 2017 |
| Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space J Reinen, JS van Leeuwen, Y Li, L Sun, PDJ Grootenhuis, CJ Decker, ... Drug metabolism and disposition 39 (9), 1568-1576, 2011 | 52 | 2011 |
| Genetic network complexity shapes background-dependent phenotypic expression J Hou, J van Leeuwen, BJ Andrews, C Boone Trends in Genetics 34 (8), 578-586, 2018 | 49 | 2018 |
| Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs JS van Leeuwen, B Ünlü, NPE Vermeulen, JC Vos Toxicology in Vitro 26 (2), 197-205, 2012 | 43 | 2012 |
| Yeast as a humanized model organism for biotransformation-related toxicity J S van Leeuwen, N PE Vermeulen, J Chris Vos Current Drug Metabolism 13 (10), 1464-1475, 2012 | 34 | 2012 |
| Mapping a diversity of genetic interactions in yeast J van Leeuwen, C Boone, BJ Andrews Current opinion in systems biology 6, 14-21, 2017 | 32 | 2017 |
| Predicting base editing outcomes using position-specific sequence determinants A Pallaseni, EM Peets, J Koeppel, J Weller, T Vanderstichele, UL Ho, ... Nucleic Acids Research 50 (6), 3551-3564, 2022 | 28 | 2022 |
| Natural variants suppress mutations in hundreds of essential genes L Parts, A Batté, M Lopes, MW Yuen, M Laver, BJ San Luis, JX Yue, ... Molecular Systems Biology 17 (5), e10138, 2021 | 26 | 2021 |
| Subunits Rip1p and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction JS van Leeuwen, R Orij, MAH Luttik, GJ Smits, NPE Vermeulen, JC Vos Microbiology 157 (3), 685-694, 2011 | 24 | 2011 |
| Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables M Shin, J van Leeuwen, C Boone, A Bretscher Molecular biology of the cell 29 (8), 923-936, 2018 | 22 | 2018 |