Xander Wehrens, MD PhD

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Prof. Dr. med. Dr. h.c. Dobromir DobrevUniversity Duisburg-Essen; University of Montreal; Baylor College of MedicineVerified email at uk-essen.de
Na Li, PhDProfessor, Medicine, Baylor College of MedicineVerified email at bcm.edu
Stephan LehnartUniversity Medical Center Goettingen; Georg-August University GoettingenVerified email at med.uni-goettingen.de
Mark E AndersonJohns Hopkins UniversityVerified email at jhmi.edu
David Y ChiangBrigham and Women's Hospital, Harvard Medical SchoolVerified email at bwh.harvard.edu
Andrew LandstromAssociate Professor, Duke University School of MedicineVerified email at duke.edu
Sameer AtherUniversity of Alabama at BirminghamVerified email at uab.edu
Stanley NattelProfessor of Medicine, Université de MontréalVerified email at icm-mhi.org
Satyam SarmaAssociate Professor; University of Texas Southwestern Medical CenterVerified email at utsouthwestern.edu
Peter J MohlerOhio State UniversityVerified email at osumc.edu

Xander Wehrens, MD PhD

Director, Cardiovascular Research Institute, Baylor College of Medicine

Verified email at bcm.edu - Homepage

Arrhythmias Atrial Fibrillation Calcium Excitation-Contraction coupling Heart failure


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FKBP12. 6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death XHT Wehrens, SE Lehnart, F Huang, JA Vest, SR Reiken, PJ Mohler, ... Cell 113 (7), 829-840, 2003	934	2003
Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction S Ather, W Chan, B Bozkurt, D Aguilar, K Ramasubbu, AA Zachariah, ... Journal of the American College of Cardiology 59 (11), 998-1005, 2012	859	2012
Ca²⁺/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor XHT Wehrens, SE Lehnart, SR Reiken, AR Marks Circulation research 94 (6), e61-e70, 2004	823	2004
Enhanced Sarcoplasmic Reticulum Ca²⁺ Leak and Increased Na⁺-Ca²⁺ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic … N Voigt, N Li, Q Wang, W Wang, AW Trafford, I Abu-Taha, Q Sun, ... Circulation 125 (17), 2059-2070, 2012	709	2012
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias SE Lehnart, XHT Wehrens, S Reiken, S Warrier, AE Belevych, RD Harvey, ... Cell 123 (1), 25-35, 2005	613	2005
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2 XHT Wehrens, SE Lehnart, SR Reiken, SX Deng, JA Vest, D Cervantes, ... Science 304 (5668), 292-296, 2004	600	2004
Calcium signaling and cardiac arrhythmias AP Landstrom, D Dobrev, XHT Wehrens Circulation research 120 (12), 1969-1993, 2017	562	2017
Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation N Voigt, J Heijman, Q Wang, DY Chiang, N Li, M Karck, XHT Wehrens, ... Circulation 129 (2), 145-156, 2014	548	2014
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen, P Jeyabal, X Pan, ... Circulation 138 (20), 2227-2242, 2018	540	2018
Evidence for multiple mechanisms in human ventricular fibrillation MP Nash, A Mourad, RH Clayton, PM Sutton, CP Bradley, M Hayward, ... Circulation 114 (6), 536-542, 2006	494*	2006
Calmodulin kinase II–mediated sarcoplasmic reticulum Ca²⁺ leak promotes atrial fibrillation in mice MG Chelu, S Sarma, S Sood, S Wang, RJ Van Oort, DG Skapura, N Li, ... The Journal of clinical investigation 119 (7), 1940-1951, 2009	476	2009
Defective cardiac ryanodine receptor regulation during atrial fibrillation JA Vest, XHT Wehrens, SR Reiken, SE Lehnart, D Dobrev, P Chandra, ... Circulation 111 (16), 2025-2032, 2005	445	2005
Intracellular calcium release and cardiac disease XHT Wehrens, SE Lehnart, AR Marks Annu. Rev. Physiol. 67, 69-98, 2005	445	2005
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression XHT Wehrens, SE Lehnart, S Reiken, JA Vest, A Wronska, AR Marks Proceedings of the National Academy of Sciences 103 (3), 511-518, 2006	428	2006
β-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure S Reiken, XHT Wehrens, JA Vest, A Barbone, S Klotz, D Mancini, ... Circulation 107 (19), 2459-2466, 2003	428	2003
Circadian rhythms govern cardiac repolarization and arrhythmogenesis D Jeyaraj, SM Haldar, X Wan, MD McCauley, JA Ripperger, K Hu, Y Lu, ... Nature 483 (7387), 96-99, 2012	414	2012
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak SE Lehnart, XHT Wehrens, PJ Laitinen, SR Reiken, SX Deng, Z Cheng, ... Circulation 109 (25), 3208-3214, 2004	391	2004
Transverse aortic constriction in mice CA Angela, RJ van Oort, XHT Wehrens Journal of visualized experiments: JoVE, 1729, 2010	385	2010
Evidence for multiple mechanisms in human ventricular fibrillation MP Nash, A Mourad, RH Clayton, PM Sutton, CP Bradley, M Hayward, ... Circulation 114 (6), 536-542, 2006	361	2006
Oxidized Ca²⁺/Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation A Purohit, AG Rokita, X Guan, B Chen, OM Koval, N Voigt, S Neef, T Sowa, ... Circulation 128 (16), 1748-1757, 2013	352	2013

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