| α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, ... Nature communications 9 (1), 2293, 2018 | 483 | 2018 |
| Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, ... Antioxidants & redox signaling 24 (7), 376-391, 2016 | 370 | 2016 |
| Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, ... Proceedings of the National Academy of Sciences 113 (9), E1206-E1215, 2016 | 237 | 2016 |
| Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation PR Angelova, ML Choi, AV Berezhnov, MH Horrocks, CD Hughes, S De, ... Cell Death & Differentiation 27 (10), 2781-2796, 2020 | 233 | 2020 |
| A mechanistic model of tau amyloid aggregation based on direct observation of oligomers SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, ... Nature communications 6 (1), 7025, 2015 | 227 | 2015 |
| Ubiquitin chain conformation regulates recognition and activity of interacting proteins Y Ye, G Blaser, MH Horrocks, MJ Ruedas-Rama, S Ibrahim, AA Zhukov, ... Nature 492 (7428), 266-270, 2012 | 212 | 2012 |
| Ca2+ is a key factor in α-synuclein-induced neurotoxicity PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, ... Journal of cell science 129 (9), 1792-1801, 2016 | 210 | 2016 |
| Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping MN Bongiovanni, J Godet, MH Horrocks, L Tosatto, AR Carr, ... Nature communications 7 (1), 13544, 2016 | 206 | 2016 |
| Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons AK Reeve, MHR Ludtmann, PR Angelova, EM Simcox, MH Horrocks, ... Cell death & disease 6 (7), e1820-e1820, 2015 | 197 | 2015 |
| PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits MJ Broadhead, MH Horrocks, F Zhu, L Muresan, R Benavides-Piccione, ... Scientific reports 6 (1), 24626, 2016 | 170 | 2016 |
| Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity ML Choi, A Chappard, BP Singh, C Maclachlan, M Rodrigues, ... Nature neuroscience 25 (9), 1134-1148, 2022 | 163 | 2022 |
| Lipid peroxidation is essential for α‐synuclein‐induced cell death PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, ... Journal of neurochemistry 133 (4), 582-589, 2015 | 157 | 2015 |
| The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, ... Journal of Biological Chemistry 293 (12), 4486-4497, 2018 | 126 | 2018 |
| Single-molecule imaging of individual amyloid protein aggregates in human biofluids MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, ... ACS Chemical Neuroscience 7 (3), 399-406, 2016 | 123 | 2016 |
| SCOTfluors: small, conjugatable, orthogonal, and tunable fluorophores for in vivo imaging of cell metabolism S Benson, A Fernandez, ND Barth, F De Moliner, MH Horrocks, ... Angewandte Chemie 131 (21), 6985-6989, 2019 | 121 | 2019 |
| Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, ... Scientific reports 5 (1), 16696, 2015 | 119 | 2015 |
| Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, ... ACS chemical biology 13 (3), 636-646, 2018 | 112 | 2018 |
| Mapping surface hydrophobicity of α-synuclein oligomers at the nanoscale JE Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, ... Nano letters 18 (12), 7494-7501, 2018 | 110 | 2018 |
| Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, ... Analytical chemistry 87 (17), 8818-8826, 2015 | 103 | 2015 |
| Synaptic oligomeric tau in Alzheimer’s disease—A potential culprit in the spread of tau pathology through the brain M Colom-Cadena, C Davies, S Sirisi, JE Lee, EM Simzer, M Tzioras, ... Neuron 111 (14), 2170-2183. e6, 2023 | 97 | 2023 |
Christopher DobsonUniversity of CambridgeVerified email at cam.ac.uk
