| The cysteinome of protein kinases as a target in drug development A Chaikuad, P Koch, SA Laufer, S Knapp Angewandte Chemie International Edition 57 (16), 4372-4385, 2018 | 220 | 2018 |
| Inhibitors of c-Jun N-terminal kinases: an update P Koch, M Gehringer, SA Laufer Journal of medicinal chemistry 58 (1), 72-95, 2015 | 123 | 2015 |
| Targeting the gatekeeper MET146 of C-Jun N-terminal kinase 3 induces a bivalent halogen/chalcogen bond A Lange, M Günther, FM Büttner, MO Zimmermann, J Heidrich, ... Journal of the American Chemical Society 137 (46), 14640-14652, 2015 | 92 | 2015 |
| Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: Synthesis and biological testing of 2-alkylsulfanyl-, 4 (5)-aryl-, 5 (4 … P Koch, C Bäuerlein, H Jank, S Laufer Journal of medicinal chemistry 51 (18), 5630-5640, 2008 | 81 | 2008 |
| Mild, selective deprotection of PMB ethers with triflic acid/1,3-dimethoxybenzene ME Jung, P Koch Tetrahedron Letters, 2011 | 77 | 2011 |
| Tri-and tetra-substituted pyrazole derivates: Regioisomerism switches activity from p38MAP kinase to important cancer kinases B Abu Thaher, M Arnsmann, F Totzke, JE Ehlert, MHG Kubbutat, ... Journal of Medicinal Chemistry 55 (2), 961-965, 2012 | 75 | 2012 |
| c-Jun N-terminal kinase inhibitors: a patent review (2010 – 2014) M Gehringer, F Muth, P Koch, SA Laufer Expert opinion on therapeutic patents 25 (8), 849-872, 2015 | 72 | 2015 |
| Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase 3 for Potential Treatment of … F Muth, M Günther, SM Bauer, E Döring, S Fischer, J Maier, ... Journal of medicinal chemistry 58 (1), 443-456, 2015 | 56 | 2015 |
| Tri-and tetrasubstituted pyridinylimidazoles as covalent inhibitors of c-Jun N-terminal kinase 3 F Muth, A El-Gokha, F Ansideri, M Eitel, E Döring, A Sievers-Engler, ... Journal of Medicinal Chemistry 60 (2), 594-607, 2017 | 49 | 2017 |
| Tri-and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors S Laufer, D Hauser, T Stegmiller, C Bracht, K Ruff, V Schattel, W Albrecht, ... Bioorganic & medicinal chemistry letters 20 (22), 6671-6675, 2010 | 47 | 2010 |
| Pyridinylquinoxalines and pyridinylpyridopyrazines as lead compounds for novel p38α mitogen-activated protein kinase inhibitors P Koch, H Jahns, V Schattel, M Goettert, S Laufer Journal of medicinal chemistry 53 (3), 1128-1137, 2010 | 46 | 2010 |
| Biological evaluation and structural determinants of p38α mitogen‐activated‐protein kinase and c‐Jun‐N‐terminal kinase 3 inhibition by flavonoids M Goettert, V Schattel, P Koch, I Merfort, S Laufer Chembiochem 11 (18), 2579-2588, 2010 | 45 | 2010 |
| Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery MO Zimmermann, A Lange, R Wilcken, MB Cieslik, TE Exner, AC Joerger, ... Future medicinal chemistry 6 (6), 617-639, 2014 | 44 | 2014 |
| SK4 channels modulate Ca2+ signalling and cell cycle progression in murine breast cancer FA Steudel, CJ Mohr, B Stegen, HY Nguyen, A Barnert, M Steinle, ... Molecular Oncology 11 (9), 1172-1188, 2017 | 43 | 2017 |
| Towards the improvement of the synthesis of novel 4 (5)-aryl-5 (4)-heteroaryl-2-thio-substituted imidazoles and their p38 MAP kinase inhibitory activity S Laufer, P Koch Organic & Biomolecular Chemistry 6 (3), 437-439, 2008 | 43 | 2008 |
| Controlling the covalent reactivity of a kinase inhibitor with light M Reynders, A Chaikuad, BT Berger, K Bauer, P Koch, S Laufer, S Knapp, ... Angewandte Chemie International Edition 60 (37), 20178-20183, 2021 | 42 | 2021 |
| Role of the hydrogen bonding heteroatom− Lys53 interaction between the p38α mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors B Abu Thaher, P Koch, V Schattel, S Laufer Journal of Medicinal Chemistry 52 (8), 2613-2617, 2009 | 39 | 2009 |
| 1, 3-Dialkyl-substituted tetrahydropyrimido [1, 2-f] purine-2, 4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases P Koch, R Akkari, A Brunschweiger, T Borrmann, M Schlenk, P Küppers, ... Bioorganic & medicinal chemistry 21 (23), 7435-7452, 2013 | 35 | 2013 |
| An Efficient Synthesis of the Protected Carbohydrate Moiety of Brasilicardin A ME Jung, P Koch Organic Letters, 2011 | 35 | 2011 |
| Structural Optimization of a Pyridinylimidazole scaffold: shifting the selectivity from p38α mitogen-activated protein kinase to c-Jun N-terminal kinase 3 F Ansideri, JT Macedo, M Eitel, A El-Gokha, DS Zinad, C Scarpellini, ... ACS omega 3 (7), 7809-7831, 2018 | 31 | 2018 |
Frank M. BoecklerUniv. Professor, Lab for Molecular Design & Pharm. Biophysics, Eberhard Karls University TuebingenVerified email at uni-tuebingen.de
