| Identification of cells initiating human melanomas T Schatton, GF Murphy, NY Frank, K Yamaura, AM Waaga-Gasser, ... Nature 451 (7176), 345-349, 2008 | 1826 | 2008 |
| Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. RM Grossman, J Krueger, D Yourish, A Granelli-Piperno, DP Murphy, ... Proceedings of the National Academy of Sciences 86 (16), 6367-6371, 1989 | 1127 | 1989 |
| Immune surveillance in the skin: mechanisms and clinical consequences TS Kupper, RC Fuhlbrigge Nature Reviews Immunology 4 (3), 211-222, 2004 | 1008 | 2004 |
| Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity X Jiang, RA Clark, L Liu, AJ Wagers, RC Fuhlbrigge, TS Kupper Nature 483 (7388), 227-231, 2012 | 1007 | 2012 |
| The vast majority of CLA+ T cells are resident in normal skin RA Clark, B Chong, N Mirchandani, NK Brinster, K Yamanaka, ... The Journal of Immunology 176 (7), 4431-4439, 2006 | 966 | 2006 |
| Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells RC Fuhlbrigge, JD Kieffer, D Armerding, TS Kupper Nature 389 (6654), 978-981, 1997 | 763 | 1997 |
| Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth S Kleffel, C Posch, SR Barthel, H Mueller, C Schlapbach, E Guenova, ... Cell 162 (6), 1242-1256, 2015 | 714 | 2015 |
| Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism Y Pan, T Tian, CO Park, SY Lofftus, S Mei, X Liu, C Luo, JT O’Malley, ... Nature 543 (7644), 252-256, 2017 | 693 | 2017 |
| Inflammatory skin diseases, T cells, and immune surveillance C Robert, TS Kupper New England Journal of Medicine 341 (24), 1817-1828, 1999 | 679 | 1999 |
| Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. H Xu, JA Gonzalo, Y St Pierre, IR Williams, TS Kupper, RS Cotran, ... The Journal of experimental medicine 180 (1), 95-109, 1994 | 617 | 1994 |
| Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells R Watanabe, A Gehad, C Yang, LL Scott, JE Teague, C Schlapbach, ... Science translational medicine 7 (279), 279ra39-279ra39, 2015 | 612 | 2015 |
| Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors JJ Campbell, RA Clark, R Watanabe, TS Kupper Blood, The Journal of the American Society of Hematology 116 (5), 767-771, 2010 | 574 | 2010 |
| The emerging role of resident memory T cells in protective immunity and inflammatory disease CO Park, TS Kupper Nature medicine 21 (7), 688-697, 2015 | 571 | 2015 |
| Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells J Seneschal, RA Clark, A Gehad, CM Baecher-Allan, TS Kupper Immunity 36 (5), 873-884, 2012 | 542 | 2012 |
| Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells R Purwar, C Schlapbach, S Xiao, HS Kang, W Elyaman, X Jiang, ... Nature medicine 18 (8), 1248-1253, 2012 | 514 | 2012 |
| Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells JA Schiro, BMC Chan, WT Roswit, PD Kassner, AP Pentland, ME Hemler, ... Cell 67 (2), 403-410, 1991 | 493 | 1991 |
| Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical … TS Kupper, DW Ballard, AO Chua, JS McGuire, PM Flood, MC Horowitz, ... The Journal of experimental medicine 164 (6), 2095-2100, 1986 | 483 | 1986 |
| Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. H Mizutani, N Schechter, G Lazarus, RA Black, TS Kupper The Journal of experimental medicine 174 (4), 821-825, 1991 | 441 | 1991 |
| Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. TS Kupper, AO Chua, P Flood, J McGuire, U Gubler The Journal of clinical investigation 80 (2), 430-436, 1987 | 438 | 1987 |
| Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients RA Clark, R Watanabe, JE Teague, C Schlapbach, MC Tawa, N Adams, ... Science translational medicine 4 (117), 117ra7-117ra7, 2012 | 402 | 2012 |
Rachael ClarkProfessor of Dermatology, Harvard medical schoolVerified email at bwh.harvard.edu
