| Characterization of purified New Delhi metallo-β-lactamase-1 PW Thomas, M Zheng, S Wu, H Guo, D Liu, D Xu, W Fast Biochemistry 50 (46), 10102-10113, 2011 | 156 | 2011 |
| Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis D Liu, BW Lepore, GA Petsko, PW Thomas, EM Stone, W Fast, D Ringe Proceedings of the National Academy of Sciences 102 (33), 11882-11887, 2005 | 149 | 2005 |
| Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain J Liao, CX Wu, C Burlak, S Zhang, H Sahm, M Wang, ZY Zhang, ... Proceedings of the National Academy of Sciences 111 (11), 4055-4060, 2014 | 145 | 2014 |
| Mechanism of the Quorum-Quenching Lactonase (AiiA) from Bacillus thuringiensis. 1. Product-Bound Structures D Liu, J Momb, PW Thomas, A Moulin, GA Petsko, W Fast, D Ringe Biochemistry 47 (29), 7706-7714, 2008 | 140 | 2008 |
| Structure and Specificity of a Quorum-Quenching Lactonase (AiiB) from Agrobacterium tumefaciens, D Liu, PW Thomas, J Momb, QQ Hoang, GA Petsko, D Ringe, W Fast Biochemistry 46 (42), 11789-11799, 2007 | 127 | 2007 |
| Mechanism of the Quorum-Quenching Lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate Modeling and Active Site Mutations J Momb, C Wang, D Liu, PW Thomas, GA Petsko, H Guo, D Ringe, W Fast Biochemistry 47 (29), 7715-7725, 2008 | 120 | 2008 |
| The protective role of DOT1L in UV-induced melanomagenesis B Zhu, S Chen, H Wang, C Yin, C Han, C Peng, Z Liu, L Wan, X Zhang, ... Nature communications 9 (1), 259, 2018 | 85 | 2018 |
| Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT R Edayathumangalam, R Wu, R Garcia, Y Wang, W Wang, CA Kreinbring, ... Proceedings of the National Academy of Sciences 110 (44), 17820-17825, 2013 | 78 | 2013 |
| Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator … JI Juncosa, K Takaya, HV Le, MJ Moschitto, PM Weerawarna, ... Journal of the American Chemical Society 140 (6), 2151-2164, 2018 | 76 | 2018 |
| The active site sulfenic acid ligand in nitrile hydratases can function as a nucleophile S Martinez, R Wu, R Sanishvili, D Liu, R Holz Journal of the American Chemical Society 136 (4), 1186-1189, 2014 | 66 | 2014 |
| Rational Design of a Transition State Analogue with Picomolar Affinity for Pseudomonas aeruginosa PvdQ, a Siderophore Biosynthetic Enzyme KD Clevenger, R Wu, JAV Er, D Liu, W Fast ACS chemical biology 8 (10), 2192-2200, 2013 | 47 | 2013 |
| Discovery and optimization of inhibitors of the Parkinson’s disease associated protein DJ-1 S Tashiro, JMM Caaveiro, M Nakakido, A Tanabe, S Nagatoishi, ... ACS chemical biology 13 (9), 2783-2793, 2018 | 44 | 2018 |
| Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115) H Lee, EH Doud, R Wu, R Sanishvili, JI Juncosa, D Liu, NL Kelleher, ... Journal of the American Chemical Society 137 (7), 2628-2640, 2015 | 40 | 2015 |
| Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site WA Al-Zyoud, RMG Hynson, LA Ganuelas, ACF Coster, AP Duff, ... Nucleic acids research 44 (3), 1411-1420, 2016 | 38 | 2016 |
| PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation R Wu, R Sanishvili, BR Belitsky, JI Juncosa, HV Le, HJS Lehrer, M Farley, ... Proceedings of the National Academy of Sciences 114 (15), 3891-3896, 2017 | 35 | 2017 |
| Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators HV Le, DD Hawker, R Wu, E Doud, J Widom, R Sanishvili, D Liu, ... Journal of the American Chemical Society 137 (13), 4525-4533, 2015 | 34 | 2015 |
| Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time Y Tu, CA Kreinbring, M Hill, C Liu, GA Petsko, CD McCune, DB Berkowitz, ... Biochemistry 57 (22), 3134-3145, 2018 | 32 | 2018 |
| The crystal structure of Nitrosomonas europaea sucrose synthase reveals critical conformational changes and insights into sucrose metabolism in prokaryotes R Wu, MD Asención Diez, CM Figueroa, M Machtey, AA Iglesias, ... Journal of bacteriology 197 (17), 2734-2746, 2015 | 32 | 2015 |
| A remarkable difference that one fluorine atom confers on the mechanisms of inactivation of human ornithine aminotransferase by two cyclohexene analogues of γ-aminobutyric acid W Zhu, PF Doubleday, DS Catlin, PM Weerawarna, A Butrin, S Shen, ... Journal of the American Chemical Society 142 (10), 4892-4903, 2020 | 28 | 2020 |
| Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis WE Karsten, L Chooback, D Liu, CC Hwang, C Lynch, PF Cook Biochemistry 38 (32), 10527-10532, 1999 | 28 | 1999 |
Greg PetskoProfessor of Neurology, Harvard Medical School and Brigham & Women's HospitalVerified email at bwh.harvard.edu
