| Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis DR Rosen, T Siddique, D Patterson, DA Figlewicz, P Sapp, A Hentati, ... Nature 362 (6415), 59-62, 1993 | 8964 | 1993 |
| Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease R Sherrington, EI Rogaev, Y Liang, EA Rogaeva, G Levesque, M Ikeda, ... Nature 375 (6534), 754-760, 1995 | 5643 | 1995 |
| Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ... Nature genetics 45 (12), 1452-1458, 2013 | 4691 | 2013 |
| Candidate gene for the chromosome 1 familial Alzheimer's disease locus E Levy-Lahad, W Wasco, P Poorkaj, DM Romano, J Oshima, ... Science 269 (5226), 973-977, 1995 | 3670 | 1995 |
| Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to … D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ... Nature medicine 2 (8), 864-870, 1996 | 3658 | 1996 |
| A polymorphic DNA marker genetically linked to Huntington's disease JF Gusella, NS Wexler, PM Conneally, SL Naylor, MA Anderson, ... Nature 306 (5940), 234-238, 1983 | 3323 | 1983 |
| Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2588 | 2019 |
| Twenty years of the Alzheimer’s disease amyloid hypothesis: a genetic perspective RE Tanzi, L Bertram Cell 120 (4), 545-555, 2005 | 2433 | 2005 |
| Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ... Nature genetics 43 (5), 429-435, 2011 | 2292 | 2011 |
| Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database L Bertram, MB McQueen, K Mullin, D Blacker, RE Tanzi Nature genetics 39 (1), 17-23, 2007 | 2255 | 2007 |
| Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ... Nature genetics 43 (5), 436-441, 2011 | 2246 | 2011 |
| Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus RE Tanzi, JF Gusella, PC Watkins, GAP Bruns, P St George-Hyslop, ... Science 235 (4791), 880-884, 1987 | 2232 | 1987 |
| Association between microdeletion and microduplication at 16p11. 2 and autism LA Weiss, Y Shen, JM Korn, DE Arking, DT Miller, R Fossdal, ... New England Journal of Medicine 358 (7), 667-675, 2008 | 1996 | 2008 |
| Rapid induction of Alzheimer Aβ amyloid formation by zinc AI Bush, WH Pettingell, G Multhaup, M d Paradis, JP Vonsattel, JF Gusella, ... Science 265 (5177), 1464-1467, 1994 | 1985 | 1994 |
| Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo W Farris, S Mansourian, Y Chang, L Lindsley, EA Eckman, MP Frosch, ... Proceedings of the National Academy of Sciences 100 (7), 4162-4167, 2003 | 1954 | 2003 |
| Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice RA Cherny, CS Atwood, ME Xilinas, DN Gray, WD Jones, CA McLean, ... Neuron 30 (3), 665-676, 2001 | 1888 | 2001 |
| The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene RE Tanzi, K Petrukhin, I Chernov, JL Pellequer, W Wasco, B Ross, ... Nature genetics 5 (4), 344-350, 1993 | 1706 | 1993 |
| Mapping autism risk loci using genetic linkage and chromosomal rearrangements Nature genetics 39 (3), 319-328, 2007 | 1676 | 2007 |
| The genetic defect causing familial Alzheimer's disease maps on chromosome 21 PH St George-Hyslop, RE Tanzi, RJ Polinsky, JL Haines, L Nee, ... Science 235 (4791), 885-890, 1987 | 1661 | 1987 |
| New insights into the genetic etiology of Alzheimer's disease and related dementias. Bellenguez Nat Genet, 2022 | 1505 | 2022 |