| Chimeric antigen receptor T cells for sustained remissions in leukemia SL Maude, N Frey, PA Shaw, R Aplenc, DM Barrett, NJ Bunin, A Chew, ... New England Journal of Medicine 371 (16), 1507-1517, 2014 | 6142 | 2014 |
| Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia SL Maude, TW Laetsch, J Buechner, S Rives, M Boyer, H Bittencourt, ... New England Journal of Medicine 378 (5), 439-448, 2018 | 5304 | 2018 |
| Chimeric antigen receptor–modified T cells in chronic lymphoid leukemia DL Porter, BL Levine, M Kalos, A Bagg, CH June New England Journal of Medicine 365 (8), 725-733, 2011 | 4676 | 2011 |
| Chimeric antigen receptor–modified T cells for acute lymphoid leukemia SA Grupp, M Kalos, D Barrett, R Aplenc, DL Porter, SR Rheingold, ... New England Journal of Medicine 368 (16), 1509-1518, 2013 | 4287 | 2013 |
| T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia M Kalos, BL Levine, DL Porter, S Katz, SA Grupp, A Bagg, CH June Science translational medicine 3 (95), 95ra73-95ra73, 2011 | 3300 | 2011 |
| Cytokine storm DC Fajgenbaum, CH June New England Journal of Medicine 383 (23), 2255-2273, 2020 | 3021 | 2020 |
| CAR T cell immunotherapy for human cancer CH June, RS O’Connor, OU Kawalekar, S Ghassemi, MC Milone Science 359 (6382), 1361-1365, 2018 | 2841 | 2018 |
| Delivery technologies for cancer immunotherapy RS Riley, CH June, R Langer, MJ Mitchell Nature reviews Drug discovery 18 (3), 175-196, 2019 | 2262 | 2019 |
| Cytokine release syndrome in severe COVID-19 JB Moore, CH June Science 368 (6490), 473-474, 2020 | 2245 | 2020 |
| A human memory T cell subset with stem cell–like properties L Gattinoni, E Lugli, Y Ji, Z Pos, CM Paulos, MF Quigley, JR Almeida, ... Nature medicine 17 (10), 1290-1297, 2011 | 2220 | 2011 |
| Chimeric antigen receptor therapy CH June, M Sadelain New England Journal of Medicine 379 (1), 64-73, 2018 | 2098 | 2018 |
| Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia DL Porter, WT Hwang, NV Frey, SF Lacey, PA Shaw, AW Loren, A Bagg, ... Science translational medicine 7 (303), 303ra139-303ra139, 2015 | 1969 | 2015 |
| Chimeric antigen receptor T cells in refractory B-cell lymphomas SJ Schuster, J Svoboda, EA Chong, SD Nasta, AR Mato, Ö Anak, ... New England Journal of Medicine 377 (26), 2545-2554, 2017 | 1893 | 2017 |
| The B7 and CD28 receptor families CH June, JA Bluestone, LM Nadler, CB Thompson Immunology today 15 (7), 321-331, 1994 | 1800 | 1994 |
| Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV P Tebas, D Stein, WW Tang, I Frank, SQ Wang, G Lee, SK Spratt, ... New England Journal of Medicine 370 (10), 901-910, 2014 | 1786 | 2014 |
| The CD28 signaling pathway regulates glucose metabolism KA Frauwirth, JL Riley, MH Harris, RV Parry, JC Rathmell, DR Plas, ... Immunity 16 (6), 769-777, 2002 | 1727 | 2002 |
| A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma DM O’Rourke, MLP Nasrallah, A Desai, JJ Melenhorst, K Mansfield, ... Science translational medicine 9 (399), eaaa0984, 2017 | 1703 | 2017 |
| CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL LH Boise, AJ Minn, PJ Noel, CH June, MA Accavitti, T Lindsten, ... Immunity 3 (1), 87-98, 1995 | 1688 | 1995 |
| Regulatory CD4+ CD25+ T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer EY Woo, CS Chu, TJ Goletz, K Schlienger, H Yeh, G Coukos, SC Rubin, ... Cancer research 61 (12), 4766-4772, 2001 | 1625 | 2001 |
| SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T … JM Chemnitz, RV Parry, KE Nichols, CH June, JL Riley The Journal of Immunology 173 (2), 945-954, 2004 | 1614 | 2004 |
Bruce L LevineBarbara and Edward Netter Professor in Cancer Gene Therapy, Department of Pathology and LaboratoryVerified email at pennmedicine.upenn.edu