Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants BL Sampaio, RA Edrada-Ebel, FB Da Costa Scientific reports 6 (1), 29265, 2016 | 505 | 2016 |
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves, MW Biavatt, R Brun, ... Current Medicinal Chemistry, 2012, 19, 2176-2228, 2012 | 388 | 2012 |
Quantitative structure− activity relationship of sesquiterpene lactones as inhibitors of the transcription Factor NF-κB B Siedle, AJ García-Piñeres, R Murillo, J Schulte-Mönting, V Castro, ... Journal of medicinal chemistry 47 (24), 6042-6054, 2004 | 319 | 2004 |
Ethnobotany, Chemistry, and Biological Activities of the Genus Tithonia (Asteraceae) DA Chagas‐Paula, RB Oliveira, BA Rocha, FB Da Costa Chemistry & Biodiversity 9 (2), 210-235, 2012 | 160 | 2012 |
Constituents of glandular trichomes of Tithonia diversifolia: relationships to herbivory and antifeedant activity SR Ambrósio, Y Oki, VCG Heleno, JS Chaves, PGBD Nascimento, ... Phytochemistry 69 (10), 2052-2060, 2008 | 151 | 2008 |
Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism DAR Valério, TM Cunha, NS Arakawa, HP Lemos, FB Da Costa, ... European journal of pharmacology 562 (1), 155-163, 2007 | 135 | 2007 |
Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle CR Tirapelli, CR de Andrade, AO Cassano, FA De Souza, SR Ambrosio, ... Journal of ethnopharmacology 110 (1), 23-29, 2007 | 131 | 2007 |
Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones DA Chagas-Paula, RB de Oliveira, VC da Silva, L Gobbo-Neto, ... Journal of Ethnopharmacology 136 (2), 355-362, 2011 | 129 | 2011 |
Sesquiterpene lactones: More than protective plant compounds with high toxicity GF Padilla-Gonzalez, FA dos Santos, FB Da Costa Critical Reviews in Plant Sciences 35 (1), 18-37, 2016 | 119 | 2016 |
Pimarane-type diterpenes: antimicrobial activity against oral pathogens TS Porto, R Rangel, NAJC Furtado, TC De Carvalho, CHG Martins, ... Molecules 14 (1), 191-199, 2009 | 119 | 2009 |
Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid AP Rogerio, C Fontanari, MCC Melo, SR Ambrosio, GEP de Souza, ... Journal of Pharmacy and Pharmacology 58 (9), 1265-1273, 2006 | 115 | 2006 |
Sesquiterpene lactone-based classification of three Asteraceae tribes: a study based on self-organizing neural networks applied to chemosystematics FB Da Costa, L Terfloth, J Gasteiger Phytochemistry 66 (3), 345-353, 2005 | 93 | 2005 |
A metabolomic approach to target compounds from the Asteraceae family for dual COX and LOX inhibition DA Chagas-Paula, T Zhang, FB Da Costa, RA Edrada-Ebel Metabolites 5 (3), 404-430, 2015 | 92 | 2015 |
Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta CR Tirapelli, SR Ambrosio, FB da Costa, ST Coutinho, DCR de Oliveira, ... European Journal of Pharmacology 492 (2-3), 233-241, 2004 | 91 | 2004 |
Kaurane and pimarane-type diterpenes from the Viguiera species inhibit vascular smooth muscle contractility SR Ambrosio, CR Tirapelli, FB da Costa, AM de Oliveira Life sciences 79 (10), 925-933, 2006 | 89 | 2006 |
Prediction of anti-inflammatory plants and discovery of their biomarkers by machine learning algorithms and metabolomic studies DA Chagas-Paula, TB Oliveira, T Zhang, RA Edrada-Ebel, FB Da Costa Planta Medica 81 (06), 450-458, 2015 | 76 | 2015 |
Diterpenes: a therapeutic promise for cardiovascular diseases AM de Oliveira, CR Tirapelli, SR Ambrosio, FB da Costa Recent Patents on Cardiovascular Drug Discovery (Discontinued) 3 (1), 1-8, 2008 | 73 | 2008 |
Renal toxicity caused by oral use of medicinal plants: the yacon example RB De Oliveira, DAC De Paula, BA Rocha, JJ Franco, L Gobbo-Neto, ... Journal of ethnopharmacology 133 (2), 434-441, 2011 | 72 | 2011 |
Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: Structure–activity relationships C Schomburg, W Schuehly, FB Da Costa, KH Klempnauer, TJ Schmidt European journal of medicinal chemistry 63, 313-320, 2013 | 71 | 2013 |
Antimicrobial ent-pimarane diterpenes from Viguiera arenaria against Gram-positive bacteria TS Porto, NAJC Furtado, VCG Heleno, CHG Martins, FB Da Costa, ... Fitoterapia 80 (7), 432-436, 2009 | 71 | 2009 |