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Victor N Uebele
Victor N Uebele
Director, Small Molecule Secreening, Merck
Verified email at merck.com
Title
Cited by
Cited by
Year
Cloning and functional expression of two families of β-subunits of the large conductance calcium-activated K+ channel
VN Uebele, A Lagrutta, T Wade, DJ Figueroa, Y Liu, E McKenna, ...
Journal of Biological Chemistry 275 (30), 23211-23218, 2000
3042000
Essential thalamic contribution to slow waves of natural sleep
F David, JT Schmiedt, HL Taylor, G Orban, G Di Giovanni, VN Uebele, ...
The Journal of Neuroscience 33 (50), 19599-19610, 2013
2392013
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of ITwindow
FM Dreyfus, A Tscherter, AC Errington, JJ Renger, HS Shin, VN Uebele, ...
The Journal of Neuroscience 30 (1), 99-109, 2010
2362010
Presynaptic HCN1 channels regulate Cav3. 2 activity and neurotransmission at select cortical synapses
Z Huang, R Lujan, I Kadurin, VN Uebele, JJ Renger, AC Dolphin, ...
Nature neuroscience 14 (4), 478-486, 2011
2122011
Presynaptic Cav3. 2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons
MO Jacus, VN Uebele, JJ Renger, SM Todorovic
The Journal of Neuroscience 32 (27), 9374-9382, 2012
1992012
Characterization of a voltage-gated K+ channel beta subunit expressed in human heart
SK England, VN Uebele, H Shear, J Kodali, PB Bennett, MM Tamkun
Proceedings of the National Academy of Sciences 92 (14), 6309-6313, 1995
1931995
High throughput ion-channel pharmacology: planar-array-based voltage clamp
L Kiss, PB Bennett, VN Uebele, KS Koblan, SA Kane, B Neagle, ...
Assay and drug development technologies 1 (1, Supplement 2), 127-135, 2003
1712003
A novel K+ channel β-subunit (hKvβ1. 3) is produced via alternative mRNA splicing
SK England, VN Uebele, J Kodali, PB Bennett, MM Tamkun
Journal of Biological Chemistry 270 (48), 28531-28534, 1995
1701995
Functional differences in Kv1. 5 currents expressed in mammalian cell lines are due to the presence of endogenous Kvβ2. 1 subunits
VN Uebele, SK England, A Chaudhary, MM Tamkun, DJ Snyders
Journal of Biological Chemistry 271 (5), 2406-2412, 1996
1681996
Molecular Analysis of a Binding Site for Quinidine in a Human Cardiac Delayed Rectifier K+ Channel Role of S6 in Antiarrhythmic Drug Binding
SW Yeola, TC Rich, VN Uebele, MM Tamkun, DJ Snyders
Circulation Research 78 (6), 1105-1114, 1996
1621996
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist
WD Shipe, JC Barrow, ZQ Yang, CW Lindsley, FV Yang, KAS Schlegel, ...
Journal of medicinal chemistry 51 (13), 3692-3695, 2008
1442008
Calcineurin signaling mediates activity-dependent relocation of the axon initial segment
MD Evans, RP Sammons, S Lebron, AS Dumitrescu, TBK Watkins, ...
The Journal of Neuroscience 33 (16), 6950-6963, 2013
1382013
State-dependent properties of a new T-type calcium channel blocker enhance Ca V 3.2 selectivity and support analgesic effects
A Francois, N Kerckhove, M Meleine, A Alloui, C Barrere, A Gelot, ...
Pain 154 (2), 283-293, 2013
1322013
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure
CJ Winrow, KQ Tanis, DR Reiss, AM Rigby, JM Uslaner, VN Uebele, ...
Neuropharmacology 58 (1), 185-194, 2010
1302010
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice
RL Kraus, Y Li, Y Gregan, AL Gotter, VN Uebele, SV Fox, SM Doran, ...
Journal of Pharmacology and Experimental Therapeutics 335 (2), 409-417, 2010
1272010
Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca2+ channels and Ca2+ release …
AH Tang, MA Karson, DA Nagode, JM McIntosh, VN Uebele, JJ Renger, ...
The Journal of Neuroscience 31 (38), 13546-13561, 2011
1082011
Antagonism of T-type calcium channels inhibits high-fat diet–induced weight gain in mice
VN Uebele, AL Gotter, CE Nuss, RL Kraus, SM Doran, SL Garson, ...
The Journal of clinical investigation 119 (6), 1659-1667, 2009
1032009
Discovery of 1, 4-substituted piperidines as potent and selective inhibitors of T-type calcium channels
ZQ Yang, JC Barrow, WD Shipe, KAS Schlegel, Y Shu, FV Yang, ...
Journal of medicinal chemistry 51 (20), 6471-6477, 2008
1002008
Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons
YG Sun, JD Pita-Almenar, CS Wu, JJ Renger, VN Uebele, HC Lu, ...
The Journal of Neuroscience 33 (5), 2048-2059, 2013
922013
T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex
C Deleuze, F David, S Béhuret, G Sadoc, HS Shin, VN Uebele, JJ Renger, ...
The Journal of Neuroscience 32 (35), 12228-12236, 2012
902012
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