| Fibrin activates GPVI in human and mouse platelets OM Alshehri, CE Hughes, S Montague, SK Watson, J Frampton, M Bender, ... Blood, The Journal of the American Society of Hematology 126 (13), 1601-1608, 2015 | 256 | 2015 |
| CLEC-2 activates Syk through dimerization CE Hughes, AY Pollitt, J Mori, JA Eble, MG Tomlinson, JH Hartwig, ... Blood, The Journal of the American Society of Hematology 115 (14), 2947-2955, 2010 | 200 | 2010 |
| CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development BA Finney, E Schweighoffer, L Navarro-Núñez, C Bénézech, F Barone, ... Blood, The Journal of the American Society of Hematology 119 (7), 1747-1756, 2012 | 179 | 2012 |
| The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC‐2 signaling in platelets JC Spalton, J Mori, AY Pollitt, CE Hughes, JA Eble, SP Watson Journal of Thrombosis and Haemostasis 7 (7), 1192-1199, 2009 | 147 | 2009 |
| Immobilized fibrinogen activates human platelets through glycoprotein VI PH Mangin, MB Onselaer, N Receveur, N Le Lay, AT Hardy, C Wilson, ... haematologica 103 (5), 898, 2018 | 145 | 2018 |
| Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib AP Bye, AJ Unsworth, MJ Desborough, CAT Hildyard, N Appleby, D Bruce, ... Blood advances 1 (26), 2610-2623, 2017 | 135 | 2017 |
| A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI‐activated platelets: Involvement of G6f, a novel platelet Grb2‐binding membrane adapter Á García, YA Senis, R Antrobus, CE Hughes, RA Dwek, SP Watson, ... Proteomics 6 (19), 5332-5343, 2006 | 120 | 2006 |
| CLEC‐2 is not required for platelet aggregation at arteriolar shear CE Hughes, L NAVARRO‐NÚÑEZ, BA Finney, D MOURÃO‐SÁ, AY Pollitt, ... Journal of Thrombosis and Haemostasis 8 (10), 2328-2332, 2010 | 109 | 2010 |
| Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells AY Pollitt, NS Poulter, E Gitz, L Navarro-Nunez, YJ Wang, CE Hughes, ... Journal of Biological chemistry 289 (52), 35695-35710, 2014 | 91 | 2014 |
| Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2) BK Manne, TM Getz, CE Hughes, O Alshehri, C Dangelmaier, UP Naik, ... Journal of Biological Chemistry 288 (11), 7717-7726, 2013 | 89 | 2013 |
| Involvement of Src kinases and PLCγ2 in clot retraction K Suzuki-Inoue, CE Hughes, O Inoue, M Kaneko, O Cuyun-Lira, ... Thrombosis research 120 (2), 251-258, 2007 | 87 | 2007 |
| Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI PLR Nicolson, CE Hughes, S Watson, SH Nock, AT Hardy, CN Watson, ... haematologica 103 (12), 2097, 2018 | 80 | 2018 |
| Low-dose Btk inhibitors selectively block platelet activation by CLEC-2 PLR Nicolson, SH Nock, J Hinds, L Garcia-Quintanilla, CW Smith, ... Haematologica 106 (1), 208, 2020 | 67 | 2020 |
| The N-terminal SH2 domain of Syk is required for (hem) ITAM, but not integrin, signaling in mouse platelets CE Hughes, BA Finney, F Koentgen, KL Lowe, SP Watson Blood, The Journal of the American Society of Hematology 125 (1), 144-154, 2015 | 62 | 2015 |
| Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC‐2 CE Hughes, JM Auger, J McGlade, JA Eble, AC Pearce, SP Watson Journal of thrombosis and haemostasis 6 (12), 2152-2159, 2008 | 62 | 2008 |
| Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets CJ Pears, K Thornber, JM Auger, CE Hughes, B Grygielska, MB Protty, ... PLoS One 3 (11), e3793, 2008 | 61 | 2008 |
| Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex R Riba, CE Hughes, A Graham, SP Watson, KM Naseem Journal of Thrombosis and Haemostasis 6 (6), 1012-1020, 2008 | 57 | 2008 |
| Minimal regulation of platelet activity by PECAM-1 TS Dhanjal, EA Ross, JM Auger, OJT McCarty, CE Hughes, YA Senis, ... Platelets 18 (1), 56-67, 2007 | 57 | 2007 |
| Critical role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type … CE Hughes, U Sinha, A Pandey, JA Eble, CA O'Callaghan, SP Watson Journal of Biological Chemistry 288 (7), 5127-5135, 2013 | 53 | 2013 |
| Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands OM Alshehri, S Montague, S Watson, P Carter, N Sarker, BK Manne, ... Biochemical Journal 468 (3), 459-473, 2015 | 52 | 2015 |
Dr. Osama M Alshehri. BSc, MSc, PhD.Department of Medical Laboratory Sciences, College of Applied Medical Sciences. Najran UniversityVerified email at nu.edu.sa
