Albumin as a versatile platform for drug half-life extension D Sleep, J Cameron, LR Evans Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (12), 5526-5534, 2013 | 564 | 2013 |
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor JT Andersen, B Dalhus, J Cameron, MB Daba, A Plumridge, L Evans, ... Nature communications 3 (1), 610, 2012 | 212 | 2012 |
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding JT Andersen, B Dalhus, D Viuff, BT Ravn, KS Gunnarsen, A Plumridge, ... Journal of Biological Chemistry 289 (19), 13492-13502, 2014 | 189 | 2014 |
Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin EGW Schmidt, ML Hvam, F Antunes, J Cameron, D Viuff, B Andersen, ... Journal of Biological Chemistry 292 (32), 13312-13322, 2017 | 78 | 2017 |
Single-chain variable fragment albumin fusions bind the neonatal Fc receptor (FcRn) in a species-dependent manner: implications for in vivo half-life evaluation of albumin … JT Andersen, J Cameron, A Plumridge, L Evans, D Sleep, I Sandlie Journal of Biological Chemistry 288 (33), 24277-24285, 2013 | 69 | 2013 |
The production, characterisation and enhanced pharmacokinetics of scFv–albumin fusions expressed in Saccharomyces cerevisiae L Evans, M Hughes, J Waters, J Cameron, N Dodsworth, D Tooth, ... Protein expression and purification 73 (2), 113-124, 2010 | 56 | 2010 |
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn) KMK Sand, M Bern, J Nilsen, B Dalhus, KS Gunnarsen, J Cameron, ... Journal of Biological Chemistry 289 (50), 34583-34594, 2014 | 55 | 2014 |
Albumin derivatives and variants A Plumridge, D Sleep, I Sandlie, JT Andersen, J Cameron, L Evans, ... US Patent 10,233,228, 2019 | 53* | 2019 |
Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs D Viuff, F Antunes, L Evans, J Cameron, H Dyrnesli, BT Ravn, ... Journal of Controlled Release 223, 22-30, 2016 | 52 | 2016 |
Albumin variants A Plumridge, D Sleep, J Cameron, I Sandlie, JT Andersen, EP Friis US Patent 8,748,380, 2014 | 52 | 2014 |
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies KMK Sand, B Dalhus, GJ Christianson, M Bern, S Foss, J Cameron, ... Journal of Biological Chemistry 289 (24), 17228-17239, 2014 | 52 | 2014 |
FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs MT Larsen, OA Mandrup, KK Schelde, Y Luo, KD Sørensen, ... Journal of Controlled Release 322, 53-63, 2020 | 38 | 2020 |
An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing K Bienk, ML Hvam, MM Pakula, F Dagnæs-Hansen, J Wengel, BM Malle, ... Journal of Controlled Release 232, 143-151, 2016 | 38 | 2016 |
Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement MT Larsen, H Rawsthorne, KK Schelde, F Dagnæs-Hansen, J Cameron, ... Journal of Controlled Release 287, 132-141, 2018 | 36 | 2018 |
Process for the purification of recombinant albumin H Van Urk, DJ Mead, PH Morton, AJ Cartwright, J Cameron, DJ Ballance, ... US Patent 7,993,877, 2011 | 34 | 2011 |
Albumin-based drug delivery using cysteine 34 chemical conjugates–important considerations and requirements MB Caspersen, M Kuhlmann, K Nicholls, MJ Saxton, B Andersen, ... Therapeutic delivery 8 (7), 511-519, 2017 | 30 | 2017 |
Albumin variants JT Andersen, B Dalhus, I Sandlie, J Cameron, A Plumridge, EP Friis, ... US Patent 8,822,417, 2014 | 27 | 2014 |
A critical examination of the role of surgery in the treatment of primary pulmonary tuberculosis in children JK Cameron, JD Hay, LJ Temple Thorax 12 (4), 329, 1957 | 26 | 1957 |
Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding J Schmøkel, A Voldum, G Tsakiridou, M Kuhlmann, J Cameron, ... Nanotechnology 28 (20), 204004, 2017 | 25 | 2017 |
Neonatal Fc receptor binding tolerance toward the covalent conjugation of payloads to cysteine 34 of human albumin variants SS Petersen, E Klaning, MF Ebbesen, B Andersen, J Cameron, ... Molecular pharmaceutics 13 (2), 677-682, 2016 | 23 | 2016 |