| The hERG potassium channel and hERG screening for drug-induced torsades de pointes JC Hancox, MJ McPate, A El Harchi, Y hong Zhang Pharmacology & therapeutics 119 (2), 118-132, 2008 | 333 | 2008 |
| hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine D Melgari, KE Brack, C Zhang, Y Zhang, A El Harchi, JS Mitcheson, ... Journal of the American Heart Association 4 (4), e001813, 2015 | 98 | 2015 |
| Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide D Melgari, Y Zhang, A El Harchi, CE Dempsey, JC Hancox Journal of Molecular and Cellular Cardiology 86, 42-53, 2015 | 73 | 2015 |
| I Ks response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules CS Nicolas, KH Park, A El Harchi, J Camonis, RS Kass, D Escande, ... Cardiovascular research 79 (3), 427-435, 2008 | 67 | 2008 |
| Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling I Adeniran, A El Harchi, JC Hancox, H Zhang Cardiovascular research 94 (1), 66-76, 2012 | 65 | 2012 |
| Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants C Du, Y Zhang, A El Harchi, CE Dempsey, JC Hancox Journal of Molecular and Cellular Cardiology 74, 220-230, 2014 | 61 | 2014 |
| Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart S Le Bouter, A El Harchi, C Marionneau, C Bellocq, A Chambellan, ... Circulation 110 (19), 3028-3035, 2004 | 61 | 2004 |
| Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking Y Zhang, CK Colenso, A El Harchi, H Cheng, HJ Witchel, CE Dempsey, ... Biochemical Pharmacology 113, 24-35, 2016 | 53 | 2016 |
| Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker MV Helliwell, Y Zhang, A El Harchi, C Du, JC Hancox, CE Dempsey Journal of Biological Chemistry 293 (18), 7040-7057, 2018 | 52 | 2018 |
| Action potential clamp and chloroquine sensitivity of mutant Kir2. 1 channels responsible for variant 3 short QT syndrome A El Harchi, MJ McPate, Y hong Zhang, H Zhang, JC Hancox Journal of molecular and cellular cardiology 47 (5), 743-747, 2009 | 52 | 2009 |
| Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis CY Du, A El Harchi, YH Zhang, CH Orchard, JC Hancox Journal of cardiovascular electrophysiology 22 (10), 1163-1170, 2011 | 46 | 2011 |
| Rabbit, a relevant model for the study of cardiac β3‐adrenoceptors L Audigane, BG Kerfant, A El Harchi, I Lorenzen‐Schmidt, G Toumaniantz, ... Experimental Physiology 94 (4), 400-411, 2009 | 40 | 2009 |
| Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation CY Du, I Adeniran, H Cheng, YH Zhang, A El Harchi, MJ McPate, H Zhang, ... Journal of cardiovascular electrophysiology 21 (10), 1160-1169, 2010 | 39 | 2010 |
| Molecular determinants of hERG potassium channel inhibition by disopyramide A El Harchi, YH Zhang, L Hussein, CE Dempsey, JC Hancox Journal of Molecular and Cellular Cardiology 52 (1), 185-195, 2012 | 37 | 2012 |
| Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria DG Whittaker, H Ni, A El Harchi, JC Hancox, H Zhang PLoS Computational Biology 13 (6), e1005593, 2017 | 33 | 2017 |
| Action potential clamp and pharmacology of the variant 1 short QT syndrome T618I hERG K+ channel A El Harchi, D Melgari, YH Zhang, H Zhang, JC Hancox PLoS One 7 (12), e52451, 2012 | 33 | 2012 |
| Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition C Du, A El Harchi, H Zhang, JC Hancox Physiological reports 1 (6), e00175, 2013 | 32 | 2013 |
| Action potential clamp and mefloquine sensitivity of recombinant'IKs' channels incorporating the V307L KCNQ1 mutation A El Harchi, MJ McPate, YH Zhang, H Zhang, CJ Hancox Journal of Physiology and Pharmacology 61 (2), 123, 2010 | 32 | 2010 |
| In silico investigation of a KCNQ1 mutation associated with short QT syndrome I Adeniran, DG Whittaker, A El Harchi, JC Hancox, H Zhang Scientific reports 7 (1), 8469, 2017 | 29 | 2017 |
| Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity A Royer, S Demolombe, A El Harchi, K Le Quang, J Piron, G Toumaniantz, ... Cardiovascular research 65 (1), 128-137, 2005 | 29 | 2005 |
Jules HancoxProfessor of Cardiac Electrophysiology, University of BristolVerified email at bristol.ac.uk
