Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis M Petljak, LB Alexandrov, JS Brammeld, S Price, DC Wedge, ... Cell 176 (6), 1282-1294. e20, 2019 | 413 | 2019 |
EMT factors and metabolic pathways in cancer I Georgakopoulos-Soares, DV Chartoumpekis, V Kyriazopoulou, ... Frontiers in oncology 10, 499, 2020 | 318 | 2020 |
A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies A Degasperi, TD Amarante, J Czarnecki, S Shooter, X Zou, D Glodzik, ... Nature cancer 1 (2), 249-263, 2020 | 223 | 2020 |
Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis I Georgakopoulos-Soares, S Morganella, N Jain, M Hemberg, ... Genome research 28 (9), 1264-1271, 2018 | 132 | 2018 |
lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements MG Gordon, F Inoue, B Martin, M Schubach, V Agarwal, S Whalen, ... Nature protocols 15 (8), 2387-2412, 2020 | 106 | 2020 |
Alternative splicing modulation by G-quadruplexes I Georgakopoulos-Soares, GE Parada, HY Wong, R Medhi, G Furlan, ... Nature communications 13 (1), 2404, 2022 | 78 | 2022 |
Deletion of CTCF sites in the SHH locus alters enhancer–promoter interactions and leads to acheiropodia A Ushiki, Y Zhang, C Xiong, J Zhao, I Georgakopoulos-Soares, L Kane, ... Nature communications 12 (1), 2282, 2021 | 54 | 2021 |
Surface antibacterial properties enhanced through engineered textures and surface roughness: A review I Georgakopoulos-Soares, EL Papazoglou, P Karmiris-Obratański, ... Colloids and Surfaces B: Biointerfaces, 113584, 2023 | 46 | 2023 |
Transcription factor binding site orientation and order are major drivers of gene regulatory activity I Georgakopoulos-Soares, C Deng, V Agarwal, CSY Chan, J Zhao, ... Nature communications 14 (1), 2333, 2023 | 44 | 2023 |
High-throughput characterization of the role of non-B DNA motifs on promoter function I Georgakopoulos-Soares, J Victorino, GE Parada, V Agarwal, J Zhao, ... Cell genomics 2 (4), 2022 | 41 | 2022 |
Secondary structures in RNA synthesis, splicing and translation I Georgakopoulos-Soares, GE Parada, M Hemberg Computational and structural biotechnology journal 20, 2871-2884, 2022 | 38 | 2022 |
High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation I Georgakopoulos-Soares, CSY Chan, N Ahituv, M Hemberg Genome biology 23 (1), 159, 2022 | 31 | 2022 |
Absent from DNA and protein: genomic characterization of nullomers and nullpeptides across functional categories and evolution I Georgakopoulos-Soares, O Yizhar-Barnea, I Mouratidis, M Hemberg, ... Genome biology 22, 1-24, 2021 | 24 | 2021 |
Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts I Georgakopoulos-Soares, G Koh, SE Momen, J Jiricny, M Hemberg, ... Nature communications 11 (1), 1980, 2020 | 24 | 2020 |
The efficacy of tumor mutation burden as a biomarker of response to immune checkpoint inhibitors C Moeckel, K Bakhl, I Georgakopoulos-Soares, A Zaravinos International journal of molecular sciences 24 (7), 6710, 2023 | 23 | 2023 |
MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development GE Parada, R Munita, I Georgakopoulos-Soares, HJR Fernandes, ... Genome biology 22, 1-26, 2021 | 22 | 2021 |
The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells GCC Koh, S Boushaki, SJ Zhao, AM Pregnall, F Sadiyah, C Badja, ... Nature Genetics 56 (1), 23-26, 2024 | 20 | 2024 |
A survey of k-mer methods and applications in bioinformatics C Moeckel, M Mareboina, MA Konnaris, CSY Chan, I Mouratidis, ... Computational and Structural Biotechnology Journal, 2024 | 15 | 2024 |
Distinct genomic features across cytolytic subgroups in skin melanoma C Roufas, I Georgakopoulos-Soares, A Zaravinos Cancer Immunology, Immunotherapy, 1-18, 2021 | 15 | 2021 |
The transcriptomic response of the murine thyroid gland to iodide overload and the role of the Nrf2 antioxidant system DV Chartoumpekis, PG Ziros, I Georgakopoulos-Soares, AAT Smith, ... Antioxidants 9 (9), 884, 2020 | 15 | 2020 |