Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids H Singh, JV Singh, K Bhagat, HK Gulati, M Sanduja, N Kumar, ... Bioorganic & medicinal chemistry 27 (16), 3477-3510, 2019 | 113 | 2019 |
Engineering CAR-T cells to activate small-molecule drugs in situ TJ Gardner, JP Lee, CM Bourne, D Wijewarnasuriya, N Kinarivala, ... Nature chemical biology 18 (2), 216-225, 2022 | 61 | 2022 |
Synthesis and antineoplastic evaluation of mitochondrial complex II (succinate dehydrogenase) inhibitors derived from atpenin A5 H Wang, B Huwaimel, K Verma, J Miller, TM Germain, N Kinarivala, ... ChemMedChem 12 (13), 1033-1044, 2017 | 60 | 2017 |
Passage variation of PC12 cells results in inconsistent susceptibility to externally induced apoptosis N Kinarivala, K Shah, TJ Abbruscato, PC Trippier ACS chemical neuroscience 8 (1), 82-88, 2017 | 46 | 2017 |
Discovery of aromatic carbamates that confer neuroprotective activity by enhancing autophagy and inducing the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) N Kinarivala, R Patel, RM Boustany, A Al-Ahmad, PC Trippier Journal of medicinal chemistry 60 (23), 9739-9756, 2017 | 42 | 2017 |
Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses J Makoukji, F Saadeh, KA Mansour, S El‐Sitt, J Al Ali, N Kinarivala, ... Annals of Clinical and Translational Neurology 5 (9), 1089-1103, 2018 | 26 | 2018 |
Multi-targeting anticancer agents: Rational approaches, synthetic routes and structure activity relationship H Singh, N Kinarivala, S Sharma Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2019 | 25 | 2019 |
Progress in the Development of Small Molecule Therapeutics for the Treatment of Neuronal Ceroid Lipofuscinoses (NCLs) Miniperspective N Kinarivala, PC Trippier Journal of medicinal chemistry 59 (10), 4415-4427, 2016 | 23 | 2016 |
An iPSC-derived neuron model of CLN3 disease facilitates small molecule phenotypic screening N Kinarivala, A Morsy, R Patel, AV Carmona, MS Sajib, S Raut, ... ACS pharmacology & translational science 3 (5), 931-947, 2020 | 21 | 2020 |
Pharmacophore elucidation of phosphoiodyn A–Potent and selective peroxisome proliferator-activated receptor β/δ agonists with neuroprotective activity N Kinarivala, JH Suh, M Botros, P Webb, PC Trippier Bioorganic & Medicinal Chemistry Letters 26 (8), 1889-1893, 2016 | 18 | 2016 |
Functional diversity of Gram-negative permeability barriers reflected in antibacterial activities and intracellular accumulation of antibiotics IV Leus, J Adamiak, B Chandar, V Bonifay, S Zhao, SS Walker, ... Antimicrobial Agents and Chemotherapy 67 (2), e01377-22, 2023 | 17 | 2023 |
Rational approaches for the design of various GABA modulators and their clinical progression K Bhagat, JV Singh, PP Pagare, N Kumar, A Sharma, G Kaur, ... Molecular diversity 25, 551-601, 2021 | 14 | 2021 |
Discovery of first-in-class peptidomimetic neurolysin activators possessing enhanced brain penetration and stability MS Rahman, S Kumari, SH Esfahani, S Nozohouri, S Jayaraman, ... Journal of medicinal chemistry 64 (17), 12705-12722, 2021 | 13 | 2021 |
Exploration of relative chemoselectivity in the hydrodechlorination of 2-chloropyridines N Kinarivala, PC Trippier Tetrahedron Letters 55 (39), 5386-5389, 2014 | 10 | 2014 |
Tailored quinolines demonstrate flexibility to exert antitumor effects through varied mechanisms-a medicinal perspective S Sharma, A Singh, S Sharma, R Sharma, J Singh, N Kinarivala, K Nepali, ... Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2021 | 6 | 2021 |
Exogenous flupirtine as potential treatment for CLN3 disease K Maalouf, J Makoukji, S Saab, NJ Makhoul, AV Carmona, N Kinarivala, ... Cells 9 (8), 1872, 2020 | 5 | 2020 |
Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes N Kinarivala, LC Standke, T Guney, C Ji, N Noguchi, Y Asano, DS Tan Methods in enzymology 638, 69-87, 2020 | 3 | 2020 |
Passage variation of PC12 cells results in inconsistent susceptibility to externally induced apoptosis. ACS Chem Neurosci. 2017; 8 (1): 82–8 N Kinarivala, K Shah, TJ Abbruscato, PC Trippier | 3 | |
Functionalized pyridine carbamates with enhanced neuroprotective activity P Trippier, N Kinarivala, RM Boustany US Patent 11,369,593, 2022 | | 2022 |
Sex-Specific Gene Expression in Flupirtine-Treated Cln3δex7/8 Mouse Brain J Makoukji, S Saab, K Maalouf, NJ Makhoul, AV Carmona, N Kinarivala, ... Biochemistry & Pharmacology: Open Access 10, 2021 | | 2021 |