The effect of HPMCAS functional groups on drug crystallization from the supersaturated state and dissolution improvement K Ueda, K Higashi, K Yamamoto, K Moribe International journal of pharmaceutics 464 (1-2), 205-213, 2014 | 135 | 2014 |
Inhibitory effect of hydroxypropyl methylcellulose acetate succinate on drug recrystallization from a supersaturated solution assessed using nuclear magnetic resonance measurements K Ueda, K Higashi, K Yamamoto, K Moribe Molecular pharmaceutics 10 (10), 3801-3811, 2013 | 124 | 2013 |
Recent progress of structural study of polymorphic pharmaceutical drugs K Higashi, K Ueda, K Moribe Advanced drug delivery reviews 117, 71-85, 2017 | 106 | 2017 |
Self‐degradable lipid‐like materials based on “hydrolysis accelerated by the intra‐particle enrichment of reactant (HyPER)” for messenger RNA delivery H Tanaka, T Takahashi, M Konishi, N Takata, M Gomi, D Shirane, ... Advanced Functional Materials 30 (34), 1910575, 2020 | 99 | 2020 |
Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements K Ueda, K Higashi, W Limwikrant, S Sekine, T Horie, K Yamamoto, ... Molecular pharmaceutics 9 (11), 3023-3033, 2012 | 75 | 2012 |
Polymer type impacts amorphous solubility and drug-rich phase colloidal stability: A mechanistic study using nuclear magnetic resonance spectroscopy K Ueda, LS Taylor Molecular Pharmaceutics 17 (4), 1352-1362, 2020 | 55 | 2020 |
Synergetic role of hypromellose and methacrylic acid copolymer in the dissolution improvement of amorphous solid dispersions N Ohyagi, K Ueda, K Higashi, K Yamamoto, K Kawakami, K Moribe Journal of Pharmaceutical Sciences 106 (4), 1042-1050, 2017 | 53 | 2017 |
Nano-scale and molecular-level understanding of wet-milled indomethacin/poloxamer 407 nanosuspension with TEM, suspended-state NMR, and Raman measurements Y Kuroiwa, K Higashi, K Ueda, K Yamamoto, K Moribe International Journal of Pharmaceutics 537 (1-2), 30-39, 2018 | 51 | 2018 |
Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution K Ueda, K Higashi, M Kataoka, S Yamashita, K Yamamoto, K Moribe European Journal of Pharmaceutical Sciences 62, 293-300, 2014 | 48 | 2014 |
Impact of hypromellose acetate succinate grade on drug amorphous solubility and in vitro membrane transport K Ueda, SS Hate, LS Taylor Journal of Pharmaceutical Sciences 109 (8), 2464-2473, 2020 | 47 | 2020 |
Direct NMR monitoring of phase separation behavior of highly supersaturated nifedipine solution stabilized with hypromellose derivatives K Ueda, K Higashi, K Moribe Molecular Pharmaceutics 14 (7), 2314-2322, 2017 | 46 | 2017 |
Cryo-TEM and AFM observation of the time-dependent evolution of amorphous probucol nanoparticles formed by the aqueous dispersion of ternary solid dispersions Z Zhao, H Katai, K Higashi, K Ueda, K Kawakami, K Moribe Molecular pharmaceutics 16 (5), 2184-2198, 2019 | 43 | 2019 |
DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy M Kawai, T Nakamura, N Miura, M Maeta, H Tanaka, K Ueda, K Higashi, ... Nanomedicine: Nanotechnology, Biology and Medicine 14 (8), 2587-2597, 2018 | 42 | 2018 |
An insight into different stabilization mechanisms of phenytoin derivatives supersaturation by HPMC and PVP N Otsuka, K Ueda, N Ohyagi, K Shimizu, K Katakawa, T Kumamoto, ... Journal of Pharmaceutical Sciences 104 (8), 2574-2582, 2015 | 42 | 2015 |
Equilibrium State at Supersaturated Drug Concentration Achieved by Hydroxypropyl Methylcellulose Acetate Succinate: Molecular Characterization Using 1H NMR … K Ueda, K Higashi, K Yamamoto, K Moribe Molecular Pharmaceutics 12 (4), 1096-1104, 2015 | 41 | 2015 |
Effect of drug–polymer interactions through hypromellose acetate succinate substituents on the physical stability on solid dispersions studied by fourier-transform infrared and … Y Ishizuka, K Ueda, H Okada, J Takeda, M Karashima, K Yazawa, ... Molecular pharmaceutics 16 (6), 2785-2794, 2019 | 40 | 2019 |
Molecular mobility suppression of ibuprofen-rich amorphous nanodroplets by HPMC revealed by NMR relaxometry and its significance with respect to crystallization inhibition K Ueda, N Yamamoto, K Higashi, K Moribe Molecular Pharmaceutics 16 (12), 4968-4977, 2019 | 39 | 2019 |
Mechanistic elucidation of formation of drug-rich amorphous nanodroplets by dissolution of the solid dispersion formulation K Ueda, K Higashi, K Moribe International Journal of Pharmaceutics 561, 82-92, 2019 | 39 | 2019 |
Mechanism of enhanced nifedipine dissolution by polymer-blended solid dispersion through molecular-level characterization K Ueda, C Yamazoe, Y Yasuda, K Higashi, K Kawakami, K Moribe Molecular Pharmaceutics 15 (9), 4099-4109, 2018 | 39 | 2018 |
Partitioning of surfactant into drug-rich nanodroplets and its impact on drug thermodynamic activity and droplet size K Ueda, LS Taylor Journal of Controlled Release 330, 229-243, 2021 | 38 | 2021 |