| Widespread proteome remodeling and aggregation in aging C. elegans DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, ... Cell 161 (4), 919-932, 2015 | 636 | 2015 |
| Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins P Ciryam, GG Tartaglia, RI Morimoto, CM Dobson, M Vendruscolo Cell reports 5 (3), 781-790, 2013 | 298 | 2013 |
| Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases P Ciryam, R Kundra, RI Morimoto, CM Dobson, M Vendruscolo Trends in pharmacological sciences 36 (2), 72-77, 2015 | 200 | 2015 |
| Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, ... Proceedings of the National Academy of Sciences 114 (20), E3935-E3943, 2017 | 117 | 2017 |
| Understanding the influence of codon translation rates on cotranslational protein folding EP O’Brien, P Ciryam, M Vendruscolo, CM Dobson Accounts of chemical research 47 (5), 1536-1544, 2014 | 115 | 2014 |
| A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease R Freer, P Sormanni, G Vecchi, P Ciryam, CM Dobson, M Vendruscolo Science advances 2 (8), e1600947, 2016 | 111 | 2016 |
| In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome P Ciryam, RI Morimoto, M Vendruscolo, CM Dobson, EP O’Brien Proceedings of the National Academy of Sciences 110 (2), E132-E140, 2013 | 111 | 2013 |
| Clinical utilization of the FilmArray meningitis/encephalitis (ME) multiplex polymerase chain reaction (PCR) assay S Radmard, S Reid, P Ciryam, A Boubour, N Ho, J Zucker, D Sayre, ... Frontiers in neurology 10, 281, 2019 | 102 | 2019 |
| Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo Proceedings of the National Academy of Sciences 114 (28), E5703-E5711, 2017 | 97 | 2017 |
| A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation P Ciryam, R Kundra, R Freer, RI Morimoto, CM Dobson, M Vendruscolo Proceedings of the National Academy of Sciences 113 (17), 4753-4758, 2016 | 95 | 2016 |
| A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data AK Sharma, P Sormanni, N Ahmed, P Ciryam, UA Friedrich, G Kramer, ... PLoS computational biology 15 (5), e1007070, 2019 | 70 | 2019 |
| SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS NE Farrawell, I Lambert-Smith, K Mitchell, J McKenna, L McAlary, ... Journal of Cell Science 131 (11), jcs209122, 2018 | 49 | 2018 |
| Identifying A-and P-site locations on ribosome-protected mRNA fragments using Integer Programming N Ahmed, P Sormanni, P Ciryam, M Vendruscolo, CM Dobson, ... Scientific reports 9 (1), 6256, 2019 | 30 | 2019 |
| The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo Neuroscience letters 704, 89-94, 2019 | 26 | 2019 |
| Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease R Freer, P Sormanni, P Ciryam, B Rammner, SO Rizzoli, CM Dobson, ... Heliyon 5 (11), 2019 | 24 | 2019 |
| Cerebrospinal analysis in patients with COVID-19 EH Miller, VS Namale, C Kim, R Dugue, G Waldrop, P Ciryam, AM Chong, ... Open forum infectious diseases 7 (11), ofaa501, 2020 | 23 | 2020 |
| A metastable subproteome underlies inclusion formation in muscle proteinopathies P Ciryam, M Antalek, F Cid, GG Tartaglia, CM Dobson, AK Guettsches, ... Acta Neuropathologica Communications 7, 1-14, 2019 | 20 | 2019 |
| Pairs of amino acids at the P-and A-sites of the ribosome predictably and causally modulate translation-elongation rates N Ahmed, UA Friedrich, P Sormanni, P Ciryam, NS Altman, B Bukau, ... Journal of molecular biology 432 (24), 166696, 2020 | 13 | 2020 |
| Interleukin-6 in Traumatic Brain Injury: A Janus-Faced Player in Damage and Repair P Ciryam, V Gerzanich, JM Simard Journal of Neurotrauma 40 (21-22), 2249-2269, 2023 | 12 | 2023 |
| Behavioral Assessment With the Coma Recovery Scale—Revised Is Safe and Feasible in Critically Ill Patients With Disorders of Consciousness MR Woodward, CL Wells, S Arnold, F Dorman, Z Ahmed, NA Morris, ... Critical care explorations 6 (7), e1101, 2024 | 2 | 2024 |
Michele VendruscoloProfessor of Biophysics, University of CambridgeVerified email at cam.ac.uk