| Angiopoietin-Tie signaling pathway in endothelial cells: a computational model Y Zhang, CD Kontos, BH Annex, AS Popel Iscience 20, 497-511, 2019 | 44 | 2019 |
| Computer simulation of TSP1 inhibition of VEGF–akt–eNOS: an angiogenesis triple threat H Bazzazi, Y Zhang, M Jafarnejad, JS Isenberg, BH Annex, AS Popel Frontiers in physiology 9, 644, 2018 | 41 | 2018 |
| Systems biology of angiogenesis signaling: Computational models and omics Y Zhang, H Wang, RHM Oliveira, C Zhao, AS Popel WIREs mechanisms of disease 14 (4), e1550, 2022 | 32 | 2022 |
| Three-dimensional transport model for intravitreal and suprachoroidal drug injection Y Zhang, H Bazzazi, RL e Silva, NB Pandey, JJ Green, PA Campochiaro, ... Investigative Ophthalmology & Visual Science 59 (12), 5266-5276, 2018 | 30 | 2018 |
| Mechanistic computational models of microRNA-mediated signaling networks in human diseases C Zhao, Y Zhang, AS Popel International journal of molecular sciences 20 (2), 421, 2019 | 26 | 2019 |
| Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma M Jafarnejad, RJ Sové, L Danilova, AC Mirando, Y Zhang, M Yarchoan, ... NPJ systems biology and applications 5 (1), 29, 2019 | 25 | 2019 |
| Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating … H Bazzazi, Y Zhang, M Jafarnejad, AS Popel Journal of theoretical biology 455, 212-221, 2018 | 23 | 2018 |
| Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager S Anbari, H Wang, Y Zhang, J Wang, M Pilvankar, M Nickaeen, S Hansel, ... Frontiers in Pharmacology 14, 1163432, 2023 | 12 | 2023 |
| A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway Y Zhang, CD Kontos, BH Annex, AS Popel npj Systems Biology and Applications 7 (1), 34, 2021 | 11 | 2021 |
| Dynamic multiscale regulation of perfusion recovery in experimental peripheral arterial disease: a mechanistic computational model C Zhao, JL Heuslein, Y Zhang, BH Annex, AS Popel Basic to Translational Science 7 (1), 28-50, 2022 | 9 | 2022 |
| Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model A Ippolito, H Wang, Y Zhang, V Vakil, H Bazzazi, AS Popel CPT: Pharmacometrics & Systems Pharmacology 13 (1), 93-105, 2024 | 7 | 2024 |
| Combining multikinase tyrosine kinase inhibitors targeting the vascular endothelial growth factor and cluster of differentiation 47 signaling pathways is predicted to increase … Y Zhang, AS Popel, H Bazzazi ACS Pharmacology & Translational Science 6 (5), 710-726, 2023 | 6 | 2023 |
| Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease Y Zhang, Y Qiang, H Li, G Li, L Lu, M Dao, GE Karniadakis, AS Popel, ... PNAS nexus 3 (2), pgae031, 2024 | 5 | 2024 |
| Virtual clinical trials via a QSP immuno-oncology model to simulate the response to a conditionally activated PD-L1 targeting antibody in NSCLC A Ippolito, H Wang, Y Zhang, V Vakil, AS Popel Journal of Pharmacokinetics and Pharmacodynamics, 1-11, 2024 | 1 | 2024 |
| Systems Biology Modeling of Complex Cellular Signaling Networks in Human Diseases Y Zhang Johns Hopkins University, 2024 | 1 | 2024 |
| Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases Y Zhang, C Zhao, AS Popel The Vasculome, 163-172, 2022 | 1 | 2022 |
| A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia G Li, Y Ma, S Zhang, W Lin, X Yao, Y Zhou, Y Zhao, Q Rao, Y Qu, Y Gao, ... Redox Biology 78, 103415, 2024 | | 2024 |
| Endothelial Regulation of Microvascular Growth and Stability by Ang‐Tie and VEGF Signaling Pathways: A Mechanistic Computational Systems Biology Model Y Zhang, CD Kontos, BH Annex, AS Popel The FASEB Journal 36, 2022 | | 2022 |
| Computational Systems Biology Modeling of the Angiopoietin‐Tie Signaling Pathway and its Crosstalk with α5β1 Integrin in Endothelial Cells Y Zhang, C Kontos, B Annex, A Popel The FASEB Journal 35, 2021 | | 2021 |
Aleksander S. PopelProfessor of Biomedical Engineering, Johns Hopkins University, School of MedicineVerified email at jhu.edu