| The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer E Kansanen, SM Kuosmanen, H Leinonen, AL Levonen Redox biology 1 (1), 45-49, 2013 | 1459 | 2013 |
| Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases A Cuadrado, AI Rojo, G Wells, JD Hayes, SP Cousin, WL Rumsey, ... Nature reviews Drug discovery 18 (4), 295-317, 2019 | 1150 | 2019 |
| Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products AL Levonen, A Landar, A Ramachandran, EK Ceaser, DA Dickinson, ... Biochemical Journal 378 (2), 373-382, 2004 | 699 | 2004 |
| Generation and biological activities of oxidized phospholipids VN Bochkov, OV Oskolkova, KG Birukov, AL Levonen, CJ Binder, J Stöckl Antioxidants & redox signaling 12 (8), 1009-1059, 2010 | 673 | 2010 |
| Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species PS Brookes, AL Levonen, S Shiva, P Sarti, VM Darley-Usmar Free Radical Biology and Medicine 33 (6), 755-764, 2002 | 397 | 2002 |
| Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease K Kanninen, R Heikkinen, T Malm, T Rolova, S Kuhmonen, H Leinonen, ... Proceedings of the National Academy of Sciences 106 (38), 16505-16510, 2009 | 332 | 2009 |
| Nuclear factor erythroid 2-related factor 2 protects against beta amyloid K Kanninen, TM Malm, HK Jyrkkänen, G Goldsteins, V Keksa-Goldsteine, ... Molecular and Cellular Neuroscience 39 (3), 302-313, 2008 | 304 | 2008 |
| Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics AL Levonen, BG Hill, E Kansanen, J Zhang, VM Darley-Usmar Free Radical Biology and Medicine 71, 196-207, 2014 | 269 | 2014 |
| Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids E Kansanen, HK Jyrkkänen, AL Levonen Free Radical Biology and Medicine 52 (6), 973-982, 2012 | 264 | 2012 |
| Human glutamate cysteine ligase gene regulation through the electrophile response element DA Dickinson, AL Levonen, DR Moellering, EK Arnold, H Zhang, ... Free Radical Biology and Medicine 37 (8), 1152-1159, 2004 | 246 | 2004 |
| KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells JO Fledderus, RA Boon, OL Volger, H Hurttila, S Ylä-Herttuala, ... Arteriosclerosis, thrombosis, and vascular biology 28 (7), 1339-1346, 2008 | 234 | 2008 |
| Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo AL Levonen, M Inkala, T Heikura, S Jauhiainen, HK Jyrkkänen, ... Arteriosclerosis, thrombosis, and vascular biology 27 (4), 741-747, 2007 | 234 | 2007 |
| Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism E Kansanen, G Bonacci, FJ Schopfer, SM Kuosmanen, KI Tong, ... Journal of Biological Chemistry 286 (16), 14019-14027, 2011 | 233 | 2011 |
| Mitochondria, nitric oxide, and cardiovascular dysfunction A Ramachandran, AL Levonen, PS Brookes, E Ceaser, S Shiva, ... Free Radical Biology and Medicine 33 (11), 1465-1474, 2002 | 207 | 2002 |
| Role of the Keap1–Nrf2 pathway in cancer HM Leinonen, E Kansanen, P Pölönen, M Heinäniemi, AL Levonen Advances in cancer research 122, 281-320, 2014 | 195 | 2014 |
| Nrf2-dependent and-independent responses to nitro-fatty acids in human endothelial cells E Kansanen, HK Jyrkkänen, OL Volger, H Leinonen, AM Kivelä, ... Journal of Biological Chemistry 284 (48), 33233-33241, 2009 | 193 | 2009 |
| Biphasic Effects of 15-Deoxy-Δ12,14-Prostaglandin J2 on Glutathione Induction and Apoptosis in Human Endothelial Cells AL Levonen, DA Dickinson, DR Moellering, RT Mulcahy, HJ Forman, ... Arteriosclerosis, thrombosis, and vascular biology 21 (11), 1846-1851, 2001 | 183 | 2001 |
| Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo HK Jyrkkänen, E Kansanen, M Inkala, AM Kivelä, H Hurttila, ... Circulation research 103 (1), e1-e9, 2008 | 182 | 2008 |
| Cytoprotection against oxidative stress and the regulation of glutathione synthesis DA Dickinson, DR Moellering, KE Iles, RP Patel, AL Levonen, A Wigley, ... Walter de Gruyter 384 (4), 527-537, 2003 | 177 | 2003 |
| Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12, 14-prostaglandin J2 E Kansanen, AM Kivelä, AL Levonen Free Radical Biology and Medicine 47 (9), 1310-1317, 2009 | 163 | 2009 |
Darley-UsmarDepartment of Pathology, University of Alabama at BirminghamVerified email at uab.edu