| The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level IB Sahra, K Laurent, A Loubat, S Giorgetti-Peraldi, P Colosetti, P Auberger, ... Oncogene 27 (25), 3576-3586, 2008 | 1112 | 2008 |
| Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1 I Ben-Sahra, JJ Howell, JM Asara, BD Manning Science 339 (6125), 1323-1328, 2013 | 844 | 2013 |
| mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning Science 351 (6274), 728-733, 2016 | 820 | 2016 |
| Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1 I Ben Sahra, C Regazzetti, G Robert, K Laurent, Y Le Marchand-Brustel, ... Cancer research 71 (13), 4366-4372, 2011 | 730 | 2011 |
| Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells I Ben Sahra, K Laurent, S Giuliano, F Larbret, G Ponzio, P Gounon, ... Cancer research 70 (6), 2465-2475, 2010 | 645 | 2010 |
| Metformin in cancer therapy: a new perspective for an old antidiabetic drug? I Ben Sahra, Y Le Marchand-Brustel, JF Tanti, F Bost Molecular cancer therapeutics 9 (5), 1092-1099, 2010 | 635 | 2010 |
| mTORC1 signaling and the metabolic control of cell growth I Ben-Sahra, BD Manning Current opinion in cell biology 45, 72-82, 2017 | 628 | 2017 |
| The TSC-mTOR pathway regulates macrophage polarization V Byles, AJ Covarrubias, I Ben-Sahra, DW Lamming, DM Sabatini, ... Nature communications 4 (1), 2834, 2013 | 626 | 2013 |
| Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation AJ Covarrubias, HI Aksoylar, J Yu, NW Snyder, AJ Worth, SS Iyer, J Wang, ... elife 5, e11612, 2016 | 412 | 2016 |
| Efferocytosis fuels requirements of fatty acid oxidation and the electron transport chain to polarize macrophages for tissue repair S Zhang, S Weinberg, M DeBerge, A Gainullina, M Schipma, JM Kinchen, ... Cell metabolism 29 (2), 443-456. e5, 2019 | 345 | 2019 |
| Hypoxia decreases insulin signaling pathways in adipocytes C Regazzetti, P Peraldi, T Grémeaux, R Najem-Lendom, I Ben-Sahra, ... Diabetes 58 (1), 95-103, 2009 | 343 | 2009 |
| Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages AJ Covarrubias, A Kale, R Perrone, JA Lopez-Dominguez, AO Pisco, ... Nature metabolism 2 (11), 1265-1283, 2020 | 320 | 2020 |
| Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production A Longchamp, T Mirabella, A Arduini, MR MacArthur, A Das, ... Cell 173 (1), 117-129. e14, 2018 | 306 | 2018 |
| Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP SJH Ricoult, JL Yecies, I Ben-Sahra, BD Manning Oncogene 35 (10), 1250-1260, 2016 | 260 | 2016 |
| Cancer cells tune the signaling pathways to empower de novo synthesis of nucleotides E Villa, ES Ali, U Sahu, I Ben-Sahra Cancers 11 (5), 688, 2019 | 246 | 2019 |
| A growing role for mTOR in promoting anabolic metabolism JJ Howell, SJH Ricoult, I Ben-Sahra, BD Manning Biochemical Society Transactions 41 (4), 906-912, 2013 | 210 | 2013 |
| The mTORC1 signaling network senses changes in cellular purine nucleotide levels G Hoxhaj, J Hughes-Hallett, RC Timson, E Ilagan, M Yuan, JM Asara, ... Cell reports 21 (5), 1331-1346, 2017 | 191 | 2017 |
| Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death I Ben-Sahra, B Dirat, K Laurent, A Puissant, P Auberger, A Budanov, ... Cell Death & Differentiation 20 (4), 611-619, 2013 | 167 | 2013 |
| Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS M Yuan, DM Kremer, H Huang, SB Breitkopf, I Ben-Sahra, BD Manning, ... Nature protocols 14 (2), 313-330, 2019 | 135 | 2019 |
| mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis E Villa, U Sahu, BP O’Hara, ES Ali, KA Helmin, JM Asara, P Gao, ... Molecular cell 81 (10), 2076-2093. e9, 2021 | 128 | 2021 |