| Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli R Schuetz, L Kuepfer, U Sauer Molecular systems biology 3 (1), 119, 2007 | 918 | 2007 |
| Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast LM Blank, L Kuepfer, U Sauer Genome biology 6, 1-16, 2005 | 410 | 2005 |
| Applied concepts in PBPK modeling: how to build a PBPK/PD model L Kuepfer, C Niederalt, T Wendl, JF Schlender, S Willmann, J Lippert, ... CPT: pharmacometrics & systems pharmacology 5 (10), 516-531, 2016 | 370 | 2016 |
| Metabolic functions of duplicate genes in Saccharomyces cerevisiae L Kuepfer, U Sauer, LM Blank Genome research 15 (10), 1421-1430, 2005 | 318 | 2005 |
| A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks T Eissing, L Kuepfer, C Becker, M Block, K Coboeken, T Gaub, L Goerlitz, ... Frontiers in physiology 2, 4, 2011 | 276 | 2011 |
| Ensemble modeling for analysis of cell signaling dynamics L Kuepfer, M Peter, U Sauer, J Stelling Nature biotechnology 25 (9), 1001-1006, 2007 | 232 | 2007 |
| Integrating cellular metabolism into a multiscale whole-body model M Krauss, S Schaller, S Borchers, R Findeisen, J Lippert, L Kuepfer PLoS computational biology 8 (10), e1002750, 2012 | 140 | 2012 |
| A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation C Thiel, S Schneckener, M Krauss, A Ghallab, U Hofmann, T Kanacher, ... Journal of pharmaceutical sciences 104 (1), 191-206, 2015 | 130 | 2015 |
| Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases A Ghallab, G Celliere, SG Henkel, D Driesch, S Hoehme, U Hofmann, ... Journal of hepatology 64 (4), 860-871, 2016 | 118 | 2016 |
| Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations W Albrecht, F Kappenberg, T Brecklinghaus, R Stoeber, R Marchan, ... Archives of toxicology 93, 1609-1637, 2019 | 109 | 2019 |
| Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling M Meyer, S Schneckener, B Ludewig, L Kuepfer, J Lippert Drug Metabolism and Disposition 40 (5), 892-901, 2012 | 107 | 2012 |
| Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood A Ghallab, U Hofmann, S Sezgin, N Vartak, R Hassan, A Zaza, P Godoy, ... Hepatology 69 (2), 666-683, 2019 | 104 | 2019 |
| A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim C Niederalt, L Kuepfer, J Solodenko, T Eissing, HU Siegmund, M Block, ... Journal of pharmacokinetics and pharmacodynamics 45, 235-257, 2018 | 94 | 2018 |
| Enabling multiscale modeling in systems medicine O Wolkenhauer, C Auffray, O Brass, J Clairambault, A Deutsch, D Drasdo, ... Genome medicine 6, 1-3, 2014 | 94 | 2014 |
| Whither systems medicine? R Apweiler, T Beissbarth, MR Berthold, N Blüthgen, Y Burmeister, ... Experimental & molecular medicine 50 (3), e453-e453, 2018 | 80 | 2018 |
| Computational models for clinical applications in personalized medicine—guidelines and recommendations for data integration and model validation CB Collin, T Gebhardt, M Golebiewski, T Karaderi, M Hillemanns, ... Journal of personalized medicine 12 (2), 166, 2022 | 76 | 2022 |
| In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice R Reif, A Ghallab, L Beattie, G Günther, L Kuepfer, PM Kaye, ... Archives of toxicology 91, 1335-1352, 2017 | 70 | 2017 |
| Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage A Schenk, A Ghallab, U Hofmann, R Hassan, M Schwarz, A Schuppert, ... Scientific Reports 7 (1), 6224, 2017 | 69 | 2017 |
| Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification M Krauss, R Burghaus, J Lippert, M Niemi, P Neuvonen, A Schuppert, ... In Silico Pharmacology 1, 1-11, 2013 | 66 | 2013 |
| Spatio-temporal simulation of first pass drug perfusion in the liver LO Schwen, M Krauss, C Niederalt, F Gremse, F Kiessling, A Schenk, ... PLoS computational biology 10 (3), e1003499, 2014 | 65 | 2014 |
Jörg LippertBayer AGVerified email at bayer.com
