Articles with public access mandates - Professor Lars KuepferLearn more
Not available anywhere: 2
Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI
S Sezgin, R Hassan, S Zühlke, L Kuepfer, JG Hengstler, M Spiteller, ...
Archives of Toxicology 92, 2963-2977, 2018
Mandates: German Research Foundation, Federal Ministry of Education and Research, Germany
Towards knowledge-driven cross-species extrapolation
C Thiel, U Hofmann, A Ghallab, R Gebhardt, JG Hengstler, L Kuepfer
Drug Discovery Today: Disease Models 22, 21-26, 2016
Mandates: Federal Ministry of Education and Research, Germany
Available somewhere: 28
Ensemble modeling for analysis of cell signaling dynamics
L Kuepfer, M Peter, U Sauer, J Stelling
Nature biotechnology 25 (9), 1001-1006, 2007
Mandates: Swiss National Science Foundation
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
W Albrecht, F Kappenberg, T Brecklinghaus, R Stoeber, R Marchan, ...
Archives of toxicology 93, 1609-1637, 2019
Mandates: European Commission, Federal Ministry of Education and Research, Germany
Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood
A Ghallab, U Hofmann, S Sezgin, N Vartak, R Hassan, A Zaza, P Godoy, ...
Hepatology 69 (2), 666-683, 2019
Mandates: Federal Ministry of Education and Research, Germany
A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim
C Niederalt, L Kuepfer, J Solodenko, T Eissing, HU Siegmund, M Block, ...
Journal of pharmacokinetics and pharmacodynamics 45, 235-257, 2018
Mandates: Federal Ministry of Education and Research, Germany
Whither systems medicine?
R Apweiler, T Beissbarth, MR Berthold, N Blüthgen, Y Burmeister, ...
Experimental & molecular medicine 50 (3), e453-e453, 2018
Mandates: Federal Ministry of Education and Research, Germany
Computational models for clinical applications in personalized medicine—guidelines and recommendations for data integration and model validation
CB Collin, T Gebhardt, M Golebiewski, T Karaderi, M Hillemanns, ...
Journal of personalized medicine 12 (2), 166, 2022
Mandates: European Commission, Federal Ministry of Education and Research, Germany
In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
R Reif, A Ghallab, L Beattie, G Günther, L Kuepfer, PM Kaye, ...
Archives of toxicology 91, 1335-1352, 2017
Mandates: UK Medical Research Council, Wellcome Trust, Federal Ministry of Education …
Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage
A Schenk, A Ghallab, U Hofmann, R Hassan, M Schwarz, A Schuppert, ...
Scientific Reports 7 (1), 6224, 2017
Mandates: Federal Ministry of Education and Research, Germany
Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling
M Verheijen, Y Schrooders, H Gmuender, R Nudischer, O Clayton, ...
Toxicology letters 294, 184-192, 2018
Mandates: UK Engineering and Physical Sciences Research Council
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity
L Kuepfer, O Clayton, C Thiel, H Cordes, R Nudischer, LM Blank, V Baier, ...
Archives of toxicology 92, 553-555, 2018
Mandates: UK Engineering and Physical Sciences Research Council
A 3D heterotypic multicellular tumor spheroid assay platform to discriminate drug effects on stroma versus cancer cells
Z Weydert, M Lal-Nag, L Mathews-Greiner, C Thiel, H Cordes, L Küpfer, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (3), 265-276, 2020
Mandates: US National Institutes of Health
Blood endotoxin levels as biomarker of nonalcoholic fatty liver disease: a systematic review and meta-analysis
J Soppert, EF Brandt, NM Heussen, E Barzakova, LM Blank, L Kuepfer, ...
Clinical Gastroenterology and Hepatology 21 (11), 2746-2758, 2023
Mandates: German Research Foundation, European Commission, Federal Ministry of …
Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: a systematic assessment
R Fendt, U Hofmann, ARP Schneider, E Schaeffeler, R Burghaus, ...
CPT: Pharmacometrics & Systems Pharmacology 10 (7), 782-793, 2021
Mandates: European Commission, Federal Ministry of Education and Research, Germany
Algorithmic surveillance of ICU patients with acute respiratory distress syndrome (ASIC): protocol for a multicentre stepped-wedge cluster randomised quality improvement strategy
G Marx, J Bickenbach, SJ Fritsch, JB Kunze, O Maassen, S Deffge, ...
BMJ open 11 (4), e045589, 2021
Mandates: Federal Ministry of Education and Research, Germany
Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney
A Ghallab, R Hassan, M Myllys, W Albrecht, A Friebel, S Hoehme, ...
Archives of Toxicology 95 (6), 2163-2177, 2021
Mandates: German Research Foundation, European Commission, Federal Ministry of …
A physiology-based model of human bile acid metabolism for predicting bile acid tissue levels after drug administration in healthy subjects and BRIC type 2 patients
V Baier, H Cordes, C Thiel, JV Castell, UP Neumann, LM Blank, L Kuepfer
Frontiers in physiology 10, 1192, 2019
Mandates: German Research Foundation, Government of Spain, Federal Ministry of …
Translational learning from clinical studies predicts drug pharmacokinetics across patient populations
M Krauss, U Hofmann, C Schafmayer, S Igel, J Schlender, C Mueller, ...
NPJ systems biology and applications 3 (1), 11, 2017
Mandates: European Commission, Federal Ministry of Education and Research, Germany
Early prediction of decompensation (EPOD) score: Non‐invasive determination of cirrhosis decompensation risk
ARP Schneider, CV Schneider, KM Schneider, V Baier, S Schaper, ...
Liver International 42 (3), 640-650, 2022
Mandates: German Research Foundation, UK Medical Research Council, Federal Ministry of …
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