| A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration L Oblak, J van der Zaag, AT Higgins-Chen, ME Levine, MP Boks Ageing research reviews 69, 101348, 2021 | 400 | 2021 |
| Biomarkers of aging for the identification and evaluation of longevity interventions M Moqri, C Herzog, JR Poganik, J Justice, DW Belsky, A Higgins-Chen, ... Cell 186 (18), 3758-3775, 2023 | 254 | 2023 |
| A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking AT Higgins-Chen, KL Thrush, Y Wang, CJ Minteer, PL Kuo, M Wang, ... Nature aging 2 (7), 644-661, 2022 | 253 | 2022 |
| Transcriptional dynamics of endodermal organ formation RI Sherwood, TYA Chen, DA Melton Developmental dynamics: an official publication of the American Association …, 2009 | 244 | 2009 |
| Validation of biomarkers of aging M Moqri, C Herzog, JR Poganik, K Ying, JN Justice, DW Belsky, ... Nature medicine 30 (2), 360-372, 2024 | 108 | 2024 |
| Schizophrenia and epigenetic aging biomarkers: increased mortality, reduced cancer risk, and unique clozapine effects AT Higgins-Chen, MP Boks, CH Vinkers, RS Kahn, ME Levine Biological Psychiatry 88 (3), 224-235, 2020 | 86 | 2020 |
| OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases G Sturm, KR Karan, AS Monzel, B Santhanam, T Taivassalo, C Bris, ... Communications biology 6 (1), 22, 2023 | 84 | 2023 |
| Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans ATY Chen, C Guo, OA Itani, BG Budaitis, TW Williams, CE Hopkins, ... Genetics 201 (2), 613-629, 2015 | 81 | 2015 |
| Effects of Caenorhabditis elegans sgk‐1 mutations on lifespan, stress resistance, and DAF‐16/FoxO regulation ATY Chen, C Guo, KJ Dumas, K Ashrafi, PJ Hu Aging cell 12 (5), 932-940, 2013 | 79 | 2013 |
| Aging biomarkers and the brain AT Higgins-Chen, KL Thrush, ME Levine Seminars in cell & developmental biology 116, 180-193, 2021 | 67 | 2021 |
| Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging N Bobba-Alves, G Sturm, J Lin, SA Ware, KR Karan, AS Monzel, C Bris, ... Psychoneuroendocrinology 155, 106322, 2023 | 47* | 2023 |
| Clock work: deconstructing the epigenetic clock signals in aging, disease, and reprogramming ME Levine, A Higgins-Chen, K Thrush, C Minteer, P Niimi BioRxiv, 2022.02. 13.480245, 2022 | 47 | 2022 |
| Longitudinal study of DNA methylation and epigenetic clocks prior to and following test-confirmed COVID-19 and mRNA vaccination APS Pang, AT Higgins-Chen, F Comite, I Raica, C Arboleda, H Went, ... Frontiers in Genetics 13, 819749, 2022 | 39 | 2022 |
| Severe illness anxiety treated by integrating inpatient psychotherapy with medical care and minimizing reassurance AT Higgins-Chen, SB Abdallah, JB Dwyer, AP Kaye, GA Angarita, ... Frontiers in psychiatry 10, 150, 2019 | 30 | 2019 |
| Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock C Minteer, M Morselli, M Meer, J Cao, A Higgins‐Chen, SM Lang, ... Aging Cell 21 (2), e13553, 2022 | 29* | 2022 |
| A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity CE Delaney, AT Chen, JV Graniel, KJ Dumas, PJ Hu Development 144 (7), 1273-1282, 2017 | 27 | 2017 |
| Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease KL Thrush, DA Bennett, C Gaiteri, S Horvath, CH van Dyck, ... Aging (Albany NY) 14 (14), 5641, 2022 | 26 | 2022 |
| Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems R Sehgal, Y Markov, C Qin, M Meer, C Hadley, AH Shadyab, R Casanova, ... BioRxiv, 2023.07. 13.548904, 2023 | 23 | 2023 |
| R methylCIPHER: a methylation clock investigational package for hypothesis-driven evaluation & research KL Thrush, AT Higgins-Chen, Z Liu, ME Levine biorxiv, 2022.07. 13.499978, 2022 | 23 | 2022 |
| The cutting edge of epigenetic clocks: In search of mechanisms linking aging and mental health ZM Harvanek, MP Boks, CH Vinkers, AT Higgins-Chen Biological psychiatry 94 (9), 694-705, 2023 | 17 | 2023 |
Morgan LevineAssistant Professor of Pathology, Yale Medical SchoolVerified email at yale.edu
