| Regulated translation initiation controls stress-induced gene expression in mammalian cells HP Harding, I Novoa, Y Zhang, H Zeng, R Wek, M Schapira, D Ron Molecular cell 6 (5), 1099-1108, 2000 | 3867 | 2000 |
| Epigenetic protein families: a new frontier for drug discovery CH Arrowsmith, C Bountra, PV Fish, K Lee, M Schapira Nature reviews Drug discovery 11 (5), 384-400, 2012 | 1614 | 2012 |
| The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015 | 880 | 2015 |
| Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation DB Yap, J Chu, T Berg, M Schapira, SWG Cheng, A Moradian, RD Morin, ... Blood, The Journal of the American Society of Hematology 117 (8), 2451-2459, 2011 | 736 | 2011 |
| Targeted protein degradation: expanding the toolbox M Schapira, MF Calabrese, AN Bullock, CM Crews Nature reviews Drug discovery 18 (12), 949-963, 2019 | 731 | 2019 |
| A systematic analysis of atomic protein–ligand interactions in the PDB RF de Freitas, M Schapira Medchemcomm 8 (10), 1970-1981, 2017 | 487 | 2017 |
| Recognition and specificity determinants of the human cbx chromodomains L Kaustov, H Ouyang, M Amaya, A Lemak, N Nady, S Duan, GA Wasney, ... Journal of Biological Chemistry 286 (1), 521-529, 2011 | 360 | 2011 |
| Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity A Schuetz, J Min, A Allali-Hassani, M Schapira, M Shuen, P Loppnau, ... Journal of Biological Chemistry 283 (17), 11355-11363, 2008 | 337 | 2008 |
| Structural biology of human H3K9 methyltransferases H Wu, J Min, VV Lunin, T Antoshenko, L Dombrovski, H Zeng, ... PloS one 5 (1), e8570, 2010 | 319 | 2010 |
| Structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins C Xu, K Liu, H Ahmed, P Loppnau, M Schapira, J Min Journal of Biological Chemistry 290 (41), 24902-24913, 2015 | 313 | 2015 |
| Protein arginine methylation: from enigmatic functions to therapeutic targeting Q Wu, M Schapira, CH Arrowsmith, D Barsyte-Lovejoy Nature reviews Drug discovery 20 (7), 509-530, 2021 | 310 | 2021 |
| Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia F Grebien, M Vedadi, M Getlik, R Giambruno, A Grover, R Avellino, ... Nature chemical biology 11 (8), 571-578, 2015 | 305 | 2015 |
| Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ... Nature communications 3 (1), 1288, 2012 | 305 | 2012 |
| WD40 repeat domain proteins: a novel target class? M Schapira, M Tyers, M Torrent, CH Arrowsmith Nature reviews Drug discovery 16 (11), 773-786, 2017 | 295 | 2017 |
| A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ... ACS chemical biology 11 (3), 772-781, 2016 | 268 | 2016 |
| Nuclear hormone receptor targeted virtual screening M Schapira, R Abagyan, M Totrov Journal of medicinal chemistry 46 (14), 3045-3059, 2003 | 227 | 2003 |
| Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking M Schapira, BM Raaka, S Das, L Fan, M Totrov, Z Zhou, SR Wilson, ... Proceedings of the National Academy of Sciences 100 (12), 7354-7359, 2003 | 225 | 2003 |
| Prediction of the binding energy for small molecules, peptides and proteins M Schapira, M Totrov, R Abagyan Journal of Molecular Recognition 12 (3), 177-190, 1999 | 225 | 1999 |
| (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ... Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014 | 193 | 2014 |
| Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase JA Newman, A Douangamath, S Yadzani, Y Yosaatmadja, A Aimon, ... Nature Communications 12 (1), 4848, 2021 | 191 | 2021 |
