| PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan L Guo, J Karpac, SL Tran, H Jasper Cell 156 (1), 109-122, 2014 | 475 | 2014 |
| Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila B Biteau, J Karpac, S Supoyo, M DeGennaro, R Lehmann, H Jasper PLoS genetics 6 (10), e1001159, 2010 | 379 | 2010 |
| Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis CG Weindel, EL Martinez, X Zhao, CJ Mabry, SL Bell, KJ Vail, ... Cell 185 (17), 3214-3231. e23, 2022 | 214 | 2022 |
| Regulation of Drosophila lifespan by JNK signaling B Biteau, J Karpac, DS Hwangbo, H Jasper Experimental gerontology 46 (5), 349-354, 2011 | 155 | 2011 |
| Notch-Mediated Suppression of TSC2 Expression Regulates Cell Differentiation in the Drosophila Intestinal Stem Cell Lineage S Kapuria, J Karpac, B Biteau, DS Hwangbo, H Jasper PLoS genetics 8 (11), e1003045, 2012 | 108 | 2012 |
| Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage J Karpac, A Younger, H Jasper Developmental cell 20 (6), 841-854, 2011 | 96 | 2011 |
| Promoting longevity by maintaining metabolic and proliferative homeostasis L Wang, J Karpac, H Jasper Journal of Experimental Biology 217 (1), 109-118, 2014 | 94 | 2014 |
| Muscle directs diurnal energy homeostasis through a myokine-dependent hormone module in Drosophila X Zhao, J Karpac Current Biology 27 (13), 1941-1955. e6, 2017 | 88 | 2017 |
| Development, maintenance, and function of the adrenal gland in early postnatal proopiomelanocortin-null mutant mice J Karpac, D Ostwald, S Bui, P Hunnewell, M Shankar, ... Endocrinology 146 (6), 2555-2562, 2005 | 87 | 2005 |
| Insulin and JNK: optimizing metabolic homeostasis and lifespan J Karpac, H Jasper Trends in Endocrinology & Metabolism 20 (3), 100-106, 2009 | 81 | 2009 |
| NF-κB shapes metabolic adaptation by attenuating Foxo-mediated lipolysis in Drosophila M Molaei, C Vandehoef, J Karpac Developmental cell 49 (5), 802-810. e6, 2019 | 78 | 2019 |
| JNK signaling in insulin‐producing cells is required for adaptive responses to stress in Drosophila J Karpac, J Hull‐Thompson, M Falleur, H Jasper Aging cell 8 (3), 288-295, 2009 | 78 | 2009 |
| Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila J Karpac, B Biteau, H Jasper Cell reports 4 (6), 1250-1261, 2013 | 73 | 2013 |
| Intestinal IRE1 is required for increased triglyceride metabolism and longer lifespan under dietary restriction NM Luis, L Wang, M Ortega, H Deng, SD Katewa, PWL Li, J Karpac, ... Cell reports 17 (5), 1207-1216, 2016 | 68 | 2016 |
| Metabolic homeostasis: HDACs take center stage J Karpac, H Jasper Cell 145 (4), 497-499, 2011 | 36 | 2011 |
| Long-chain n-3 fatty acids attenuate oncogenic kras-driven proliferation by altering plasma membrane nanoscale proteolipid composition NR Fuentes, M Mlih, R Barhoumi, YY Fan, P Hardin, TJ Steele, S Behmer, ... Cancer research 78 (14), 3899-3912, 2018 | 31 | 2018 |
| Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila X Zhao, J Karpac Cell metabolism 33 (12), 2428-2444. e8, 2021 | 24 | 2021 |
| Pro-opiomelanocortin peptides and the adrenal gland J Karpac, A Kern, U Hochgeschwender Molecular and Cellular Endocrinology 265, 29-33, 2007 | 24 | 2007 |
| The Drosophila midgut and the systemic coordination of lipid-dependent energy homeostasis X Zhao, J Karpac Current opinion in insect science 41, 100-105, 2020 | 22 | 2020 |
| Aging: seeking mitonuclear balance J Karpac, H Jasper Cell 154 (2), 271-273, 2013 | 21 | 2013 |
heinrich jasperStaff Scientist, GenentechVerified email at gene.com
