| DNA targeting specificity of RNA-guided Cas9 nucleases PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ... Nature biotechnology 31 (9), 827-832, 2013 | 5711 | 2013 |
| CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity TJ Cradick, EJ Fine, CJ Antico, G Bao Nucleic acids research 41 (20), 9584-9592, 2013 | 811 | 2013 |
| CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences Y Lin, TJ Cradick, MT Brown, H Deshmukh, P Ranjan, N Sarode, BM Wile, ... Nucleic acids research 42 (11), 7473-7485, 2014 | 777 | 2014 |
| Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection L Ye, J Wang, AI Beyer, F Teque, TJ Cradick, Z Qi, JC Chang, G Bao, ... Proceedings of the National Academy of Sciences 111 (26), 9591-9596, 2014 | 430 | 2014 |
| COSMID: a web-based tool for identifying and validating CRISPR/Cas off-target sites TJ Cradick, P Qiu, CM Lee, EJ Fine, G Bao Molecular Therapy-Nucleic Acids 3, 2014 | 426 | 2014 |
| Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome M Müller, CM Lee, G Gasiunas, TH Davis, TJ Cradick, V Siksnys, G Bao, ... Molecular Therapy 24 (3), 636-644, 2016 | 313 | 2016 |
| The Neisseria meningitidis CRISPR-Cas9 system enables specific genome editing in mammalian cells CM Lee, TJ Cradick, G Bao Molecular Therapy 24 (3), 645-654, 2016 | 274 | 2016 |
| TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity C Mussolino, J Alzubi, EJ Fine, R Morbitzer, TJ Cradick, T Lahaye, G Bao, ... Nucleic acids research 42 (10), 6762-6773, 2014 | 246 | 2014 |
| Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects CL Ramirez, MT Certo, C Mussolino, MJ Goodwin, TJ Cradick, ... Nucleic Acids Research, 2012 | 238 | 2012 |
| Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis b virus DNAs TJ Cradick, K Keck, S Bradshaw, AC Jamieson, AP McCaffrey Molecular Therapy 18 (5), 947-954, 2010 | 228 | 2010 |
| Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus C Antoniani, V Meneghini, A Lattanzi, T Felix, O Romano, E Magrin, ... Blood, The Journal of the American Society of Hematology 131 (17), 1960-1973, 2018 | 227 | 2018 |
| An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage EJ Fine, TJ Cradick, CL Zhao, Y Lin, G Bao Nucleic acids research 42 (6), e42-e42, 2014 | 159 | 2014 |
| Nuclease target site selection for maximizing on-target activity and minimizing off-target effects in genome editing CM Lee, TJ Cradick, EJ Fine, G Bao Molecular Therapy 24 (3), 475-487, 2016 | 145 | 2016 |
| A burden of rare variants associated with extremes of gene expression in human peripheral blood J Zhao, I Akinsanmi, D Arafat, TJ Cradick, CM Lee, S Banskota, ... The American Journal of Human Genetics 98 (2), 299-309, 2016 | 107 | 2016 |
| Defining critical residues in the epitope for a hiv-neutralizing monoclonal antibody using phage display and peptide array technologies CL Jellis, TJ Cradick, P Rennert, P Salinas, J Boyd, T Amirault, GS Gray Gene 137 (1), 63-68, 1993 | 77 | 1993 |
| SAPTA: a new design tool for improving TALE nuclease activity Y Lin, EJ Fine, Z Zheng, CJ Antico, RA Voit, MH Porteus, TJ Cradick, ... Nucleic acids research 42 (6), e47-e47, 2014 | 70 | 2014 |
| Efficient fdCas9 synthetic endonuclease with improved specificity for precise genome engineering M Aouida, A Eid, Z Ali, T Cradick, C Lee, H Deshmukh, A Atef, ... PloS one 10 (7), e0133373, 2015 | 69 | 2015 |
| ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites TJ Cradick, G Ambrosini, C Iseli, P Bucher, AP McCaffrey BMC bioinformatics 12 (1), 152, 2011 | 62 | 2011 |
| TALENs facilitate single-step seamless SDF correction of F508del CFTR in airway epithelial submucosal gland cell-derived CF-iPSCs S Suzuki, RG Sargent, B Illek, H Fischer, A Esmaeili-Shandiz, MJ Yezzi, ... Molecular Therapy-Nucleic Acids 5, 2016 | 51 | 2016 |
| Evaluation of homology-independent CRISPR-Cas9 off-target assessment methods HG Chaudhari, J Penterman, HJ Whitton, SJ Spencer, N Flanagan, ... The CRISPR Journal 3 (6), 440-453, 2020 | 48 | 2020 |
Gang BaoFoyt Family Professor, Bioengineering, Rice UniversityVerified email at rice.edu
