Epigenetics in rheumatoid arthritis K Klein, S Gay Current opinion in rheumatology 27 (1), 76-82, 2015 | 187 | 2015 |
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts J Friščić, M Böttcher, C Reinwald, H Bruns, B Wirth, SJ Popp, KI Walker, ... Immunity 54 (5), 1002-1021. e10, 2021 | 178 | 2021 |
Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions M Frank-Bertoncelj, M Trenkmann, K Klein, E Karouzakis, H Rehrauer, ... Nature communications 8 (1), 14852, 2017 | 177 | 2017 |
The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts K Klein, PA Kabala, AM Grabiec, RE Gay, C Kolling, LL Lin, S Gay, ... Annals of the rheumatic diseases 75 (2), 422-429, 2016 | 168 | 2016 |
Dual role of autophagy in stress‐induced cell death in rheumatoid arthritis synovial fibroblasts M Kato, C Ospelt, RE Gay, S Gay, K Klein Arthritis & rheumatology 66 (1), 40-48, 2014 | 164 | 2014 |
Complex haplotypes of the PGC-1α gene are associated with carbohydrate metabolism and type 2 diabetes H Oberkofler, V Linnemayr, R Weitgasser, K Klein, M Xie, B Iglseder, ... Diabetes 53 (5), 1385-1393, 2004 | 137 | 2004 |
Epigenetics in the pathogenesis of RA C Ospelt, S Gay, K Klein Seminars in immunopathology 39, 409-419, 2017 | 114 | 2017 |
Epigenetic contributions in the development of rheumatoid arthritis K Klein, C Ospelt, S Gay Arthritis Research & Therapy 14, 1-7, 2012 | 89 | 2012 |
Role of peroxisome proliferator-activated receptor-γ coactivator-1α in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells H Oberkofler, K Klein, TK Felder, F Krempler, W Patsch Endocrinology 147 (2), 966-976, 2006 | 79 | 2006 |
Epigenetic modifications in rheumatoid arthritis, a review K Klein, S Gay Current opinion in pharmacology 13 (3), 420-425, 2013 | 73 | 2013 |
Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis R Knevel, K Klein, K Somers, C Ospelt, JJ Houwing-Duistermaat, ... Annals of the rheumatic diseases 73 (11), 2038-2046, 2014 | 71 | 2014 |
Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women H Oberkofler, B Iglseder, K Klein, J Unger, M Haltmayer, F Krempler, ... Arteriosclerosis, thrombosis, and vascular biology 25 (3), 604-610, 2005 | 71 | 2005 |
Retinol-binding protein 4 in polycystic ovary syndrome—association with steroid hormones and response to pioglitazone treatment E Aigner, N Bachofner, K Klein, C De Geyter, F Hohla, W Patsch, C Datz The Journal of Clinical Endocrinology & Metabolism 94 (4), 1229-1235, 2009 | 59 | 2009 |
Bromodomain protein inhibition: a novel therapeutic strategy in rheumatic diseases K Klein RMD open 4 (2), e000744, 2018 | 58 | 2018 |
Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability X Ge, M Frank-Bertoncelj, K Klein, A McGovern, T Kuret, M Houtman, ... Genome biology 22, 1-39, 2021 | 48 | 2021 |
ATP induced brain-derived neurotrophic factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic receptor P2X4 K Klein, A Aeschlimann, S Jordan, R Gay, S Gay, H Sprott PLoS One 7 (5), e36693, 2012 | 46 | 2012 |
The human organic anion transporter genes OAT5 and OAT7 are transactivated by hepatocyte nuclear factor-1α (HNF-1α) K Klein, C Jüngst, J Mwinyi, B Stieger, F Krempler, W Patsch, JJ Eloranta, ... Molecular pharmacology 78 (6), 1079-1087, 2010 | 42 | 2010 |
SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts A Engler, F Niederer, K Klein, RE Gay, D Kyburz, GG Camici, S Gay, ... Journal of molecular medicine 92, 757-767, 2014 | 39 | 2014 |
The epigenetic architecture at gene promoters determines cell type-specific LPS tolerance K Klein, M Frank-Bertoncelj, E Karouzakis, RE Gay, C Kolling, A Ciurea, ... Journal of autoimmunity 83, 122-133, 2017 | 38 | 2017 |
Interplay between genetic and epigenetic mechanisms in rheumatoid arthritis M Frank-Bertoncelj, K Klein, S Gay Epigenomics 9 (4), 493-504, 2017 | 34 | 2017 |