| Signal integration in the endoplasmic reticulum unfolded protein response D Ron, P Walter Nature reviews Molecular cell biology 8 (7), 519-529, 2007 | 7413 | 2007 |
| The unfolded protein response: from stress pathway to homeostatic regulation P Walter, D Ron science 334 (6059), 1081-1086, 2011 | 6445 | 2011 |
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase HP Harding, Y Zhang, D Ron Nature 397 (6716), 271-274, 1999 | 4032 | 1999 |
| Regulated translation initiation controls stress-induced gene expression in mammalian cells HP Harding, I Novoa, Y Zhang, H Zeng, R Wek, M Schapira, D Ron Molecular cell 6 (5), 1099-1108, 2000 | 3866 | 2000 |
| An integrated stress response regulates amino acid metabolism and resistance to oxidative stress HP Harding, Y Zhang, H Zeng, I Novoa, PD Lu, M Calfon, N Sadri, C Yun, ... Molecular cell 11 (3), 619-633, 2003 | 3842 | 2003 |
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response A Bertolotti, Y Zhang, LM Hendershot, HP Harding, D Ron Nature cell biology 2 (6), 326-332, 2000 | 3552 | 2000 |
| Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 F Urano, XZ Wang, A Bertolotti, Y Zhang, P Chung, HP Harding, D Ron science 287 (5453), 664-666, 2000 | 3540 | 2000 |
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA M Calfon, H Zeng, F Urano, JH Till, SR Hubbard, HP Harding, SG Clark, ... Nature 415 (6867), 92-96, 2002 | 3382 | 2002 |
| Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress I Tabas, D Ron Nature cell biology 13 (3), 184-190, 2011 | 2931 | 2011 |
| Perk is essential for translational regulation and cell survival during the unfolded protein response HP Harding, Y Zhang, A Bertolotti, H Zeng, D Ron Molecular cell 5 (5), 897-904, 2000 | 2485 | 2000 |
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum H Zinszner, M Kuroda, XZ Wang, N Batchvarova, RT Lightfoot, H Remotti, ... Genes & development 12 (7), 982-995, 1998 | 2437 | 1998 |
| CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum SJ Marciniak, CY Yun, S Oyadomari, I Novoa, Y Zhang, R Jungreis, ... Genes & development 18 (24), 3066-3077, 2004 | 2299 | 2004 |
| Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2 J Nangalia, CE Massie, EJ Baxter, FL Nice, G Gundem, DC Wedge, ... New England Journal of Medicine 369 (25), 2391-2405, 2013 | 2236 | 2013 |
| Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α I Novoa, H Zeng, HP Harding, D Ron The Journal of cell biology 153 (5), 1011-1022, 2001 | 1730 | 2001 |
| A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress M Boyce, KF Bryant, C Jousse, K Long, HP Harding, D Scheuner, ... Science 307 (5711), 935-939, 2005 | 1693 | 2005 |
| GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2, 3-dioxygenase DH Munn, MD Sharma, B Baban, HP Harding, Y Zhang, D Ron, AL Mellor Immunity 22 (5), 633-642, 2005 | 1476 | 2005 |
| CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene … D Ron, JF Habener Genes & development 6 (3), 439-453, 1992 | 1472 | 1992 |
| Diabetes mellitus and exocrine pancreatic dysfunction in perk−/− mice reveals a role for translational control in secretory cell survival HP Harding, H Zeng, Y Zhang, R Jungries, P Chung, H Plesken, ... Molecular cell 7 (6), 1153-1163, 2001 | 1458 | 2001 |
| A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol Y Ye, Y Shibata, C Yun, D Ron, TA Rapoport Nature 429 (6994), 841-847, 2004 | 1207 | 2004 |
| Endoplasmic reticulum stress signaling in disease SJ Marciniak, D Ron Physiological reviews 86 (4), 1133-1149, 2006 | 1163 | 2006 |